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Chemical Compound Review

THIOINOSINE     9-[(2R,3R,4S,5R)-3,4- dihydroxy-5...

Synonyms: Thionosine, Tioinosine, SureCN25230, CHEMBL448290, NSC-4911, ...
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Disease relevance of THIOINOSINE


High impact information on THIOINOSINE


Anatomical context of THIOINOSINE

  • (Na+ + K+)-activated ATPase in beef brain microsomes is inactivated by the disulfide of thionosine tri[gamma-32P]phosphate, an ATP analog [7].

Gene context of THIOINOSINE

  • 4. At 5 and 48 h the 2 microM and 10 microM 6MP incubations contained both 6MP and its initial nucleotide metabolite, thioinosine 5'-monophosphate (TIMP) [8].


  1. 2'-O-Acyl-6-thioinosine cyclic 3',5'-phosphates as prodrugs of thioinosinic acid. Meyer, R.B., Stone, T.E., Ullman, B. J. Med. Chem. (1979) [Pubmed]
  2. Multidrug-resistance protein 5 is a multispecific organic anion transporter able to transport nucleotide analogs. Wijnholds, J., Mol, C.A., van Deemter, L., de Haas, M., Scheffer, G.L., Baas, F., Beijnen, J.H., Scheper, R.J., Hatse, S., De Clercq, E., Balzarini, J., Borst, P. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  3. Adverse events leading to modification of therapy in a large cohort of patients with inflammatory bowel disease. Hindorf, U., Lindqvist, M., Hildebrand, H., Fagerberg, U., Almer, S. Aliment. Pharmacol. Ther. (2006) [Pubmed]
  4. Reduced cellular transport and activation of fluoropyrimidine nucleosides and resistance in human lymphocytic cell lines selected for arabinosylcytosine resistance. Agarwal, R.P., Han, T., Fernandez, M. Biochem. Pharmacol. (2001) [Pubmed]
  5. A clinically useful ion-pairing high-performance liquid chromatographic assay for the monophosphate metabolites of thioguanine and mercaptopurine in human neoplastic cells. Zimm, S., Strong, J.M. Anal. Biochem. (1987) [Pubmed]
  6. Demonstration of two different reactive sulfhydryl groups in the ATP-binding sites of Ca2+-ATPase of sarcoplasmic reticulum by disulfides of thioinosine triphosphates. Patzelt-Wenczler, R., Kreickmann, H., Schoner, W. Eur. J. Biochem. (1980) [Pubmed]
  7. Disulfide of thionosine triphosphate, an ATP-analog inactivating (Na+ + K+)-ATPase. Patzelt-Wenczler, R., Schoner, W. Biochim. Biophys. Acta (1975) [Pubmed]
  8. In vitro metabolism of 6-mercaptopurine by human liver cytosol. Rowland, K., Lennard, L., Lilleyman, J.S. Xenobiotica (1999) [Pubmed]
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