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Chemical Compound Review:

Perfluamina 1,1,2,2,3,3,3-heptafluoro- N,N-bis(1,1,2,2...

Synonyms: Perfluamine, FTPA, Perfluaminum, CHEMBL2104877, CHEBI:38850, ...

Mishima, H. et al., Taylor, J. et al., Lutz, J. et al., Lutz, J. et al., Meyer, K.L. et al., et al.

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Disease relevance of Perfluamine

Oxygen concentrations in Paracoccus denitrificans and insulinoma cells, RINm5F, in the NMR probe can be monitored directly by 1/T1 measurements of perfluorotripropylamine (FTPA)/lecithin emulsion added to the suspensions [1].
The effect of an emulsion of perfluorochemicals (PFC) (7 parts perfluorodecalin and 3 parts perfluorotripropylamine, 4.4 g PFC/kg body weight) on organ function was determined [2].
Perfluorodecalin and perfluorotripropylamine which have N2 solubility coefficients of 28.4 and 35.7 ml/dl, respectively, were used for treatment of decompression sickness in this study [3].

High impact information on Perfluamine

The authors investigate organ retention of the blood substitute component, perfluorotripropylamine (FTPA), using fluorine-19 (19F) magnetic resonance imaging (MRI) [4].
A mixture of perfluoromethyldecahydroisoquinoline (FMIQ) emulsion coupled with anti-CEA (carcinoembryonic antigen) antibody and perfluorotripropylamine (FTPA) was injected into a nude mouse inoculated with human colon carcinoma LS174T [5].

Analytical, diagnostic and therapeutic context of Perfluamine

The test group received oxygen-saturated perfluorotripropylamine (FTPA), and the control group received oxygen desaturated FTPA [6].

References

19F-nuclear magnetic resonance: measurements of [O2] and pH in biological systems. Taylor, J., Deutsch, C. Biophys. J. (1988) [Pubmed]
Effects of potential blood substitutes (perfluorochemicals) on rat liver and spleen. Lutz, J., Metzenauer, P. Pflugers Arch. (1980) [Pubmed]
Perfluorochemicals as a treatment of decompression sickness in rats. Lutz, J., Herrmann, G. Pflugers Arch. (1984) [Pubmed]
Fluorinated blood substitute retention in the rat measured by fluorine-19 magnetic resonance imaging. Meyer, K.L., Carvlin, M.J., Mukherji, B., Sloviter, H.A., Joseph, P.M. Investigative radiology. (1992) [Pubmed]
In vivo F-19 chemical shift imaging with FTPA and antibody-coupled FMIQ. Mishima, H., Kobayashi, T., Shimizu, M., Tamaki, Y., Baba, M., Shimano, T., Itoh, S., Yamazaki, M., Iriguchi, N., Takahashi, M. Journal of magnetic resonance imaging : JMRI. (1991) [Pubmed]
Transabdominal oxygenation using perfluorocarbons. Chiba, T., Harrison, M.R., Ohkubo, T., Rollins, M.D., Albanese, C.T., Jennings, R.W. J. Pediatr. Surg. (1999) [Pubmed]

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