Disease relevance of Perflunafene

• The perfluorocarbons, perfluorodecalin (PFD), and perfluoro-tripropylamine (PFTP) in a 50 volume/percent concentration exhibited profound effects on adherence, particularly on cells subjected to anoxia (51% and 69% reduction in adherence, respectively; P less than 0.01) [1].
• Perfluorodecalin is a superior artificial oxygen carrier because of its high oxygen dissolving capacity, low toxicity, and short retention times within tissues [2].
• Delayed sequential occurrence of perfluorodecalin and silicone oil in the subretinal space following retinal detachment surgery in the presence of an optic disc pit [3].
• Enhancing the photodynamic effect of hypericin in human bladder transitional cell carcinoma spheroids by the use of the oxygen carrier, perfluorodecalin [4].
• Effect of perfluorodecalin as an oxygen carrier on actinorhodin production by Streptomyces coelicolor A3(2) [5].

High impact information on Perflunafene

• In both the liquid ventilation groups the lung compliance improved with the instillation of perfluorodecalin (from 0.46 SD 0.18 to 0.62 SD 0.09 ml/cm H(2)O/kg in the PLV alone group at 1 h, p < 0.05 compared with the control group) and remained stable for the remainder of the study [6].
• Three different doses of perfluorodecalin (9 ml/kg = low dose; 13.5 ml/kg = medium dose; 18 ml/kg = functional residual capacity [FRC] dose) were applied in random order during PLV [7].
• OBJECTIVE: To examine whether chemically different perfluorochemical liquids (PFC) (perfluorodecalin [PFD]; perflubron [PFB]) induce inflammatory responses in blood leukocytes [8].
• PFD induced a small though significant increase in interleukin-8 secretion [8].
• A stable emulsion of perfluorodecalin, made up of 34 percent (vol/vol) perfluorodecalin dispersed by sonication in isotonic Tyrode's buffer (pH 7.4) containing egg yolk lecithin, has been developed [9].

Chemical compound and disease context of Perflunafene

• The doses used amounted to 4.4, 10 and 14 g/kg body weight of Fluosol-DA, an emulsion of 7 parts of perfluorodecalin (FDC) and 3 parts of perfluorotripropylamine (FTPA) [10].
• Treatment of early giant retinal tears with domestic perfluorodecalin and perfluoropropane [11].

Biological context of Perflunafene

• The detection of nuclear shrinkage or fragmentation with DAPI staining and the assessment of cell morphology by light microscopy indicated that apoptosis was the most prominent response of spheroids to hypericin PDT in the presence of perfluorodecalin [4].
• Lung histology revealed significantly less hyaline membrane formation in the PLV group (P < .05) [12].
• Because cell proliferation showed no significant changes the results suggest that perfluorodecalin may not be directly toxic to cells in vitro [13].
• The activity of the hepatic phase II enzymes of xenobiotic biotransformation after intravenous administration of perfluorodecalin emulsion to rats was measured [14].
• Viable cell counts revealed that perfluorodecalin or the commercial emulsion, Fluosol-DA 20%, produced no obvious growth-inhibition over 6h [15].

Anatomical context of Perflunafene

• Efficacy of perfluorodecalin as an oxygen carrier for mouse and rat testes perfused in vitro [2].
• This question was examined by comparing testosterone secretion by testes perfused in vitro with medium incorporating either perfluorodecalin or erythrocytes as oxygen carriers [2].
• The bile duct was cannulated in rats that had been infused intravenously with an emulsion of perfluorodecalin at intervals from 2 to 34 weeks earlier [16].
• Rat livers have been perfused with a saline control medium or with a perfluorocarbon emulsion containing perfluorodecalin and N,N-perfluorodiethylcyclohexylamine, and the respiratory rates and transmembrane electrical potentials of mitochondria isolated following perfusion have been evaluated [17].
• Perfluorodecalin was found under the superior conjunctiva [18].

Associations of Perflunafene with other chemical compounds

• In vivo 19F nuclear magnetic resonance (NMR) images were acquired at 57.9 MHz in rats receiving chronic injections of 14% perfluorodecalin, 6% perfluorotripropylamine (Fluosol-DA) [19].
• Efficacy of electrocautery in different media: air, perfluorodecalin, glycerine, glycine, and electrolyte solution [20].
• MATERIALS AND METHODS: Using bipolar electrocautery, lesions were made in 16 skin/cartilage specimens from the ears of New Zealand White rabbits in 5 different media: air, 85% glycerine, 1.5% glycine, electrolyte solution, and perfluorodecalin [20].
• PFH nanoparticles exhibited the greatest enhancement, and PFD nanoparticles showed the least [21].
• Effects of the perfluorodecalin emulsion thus prepared for maintaining contractile force of isolated guinea pig heart by perfusion and survival of animals receiving repeated circulatory exchange proved similar to perfluorotributylamine/Pluronic F68 emulsion [22].

Gene context of Perflunafene

• First, is perfluorodecalin deleterious to the endocrine function of testes [2]?
• Pancreas storage in oxygenated perfluorodecalin does not restore post-transplant function of isolated pig islets pre-damaged by warm ischemia [23].
• Perflubron or perfluorodecalin did not induce significant differences in ET-1 or NO(-2)/NO(-3) levels as function of PFC type or dose [24].
• Perfluorodecalin was found to increase the microsomal glutathione S-transferase and UDP-glucuronosyltransferase activities 1.4- and 2.3-fold, respectively [14].
• These results show that perfluorodecalin is an inducer of both the enzymes of cytochrome P-450-dependent monooxygenase system [Mishin V. et al (1989) Chem.-Biol. Interactions, 72, 143-155.] and those catalyzing conjugation reactions: microsomal glutathione S-transferase and UDP-glucuronosyltransferase [14].

Analytical, diagnostic and therapeutic context of Perflunafene

• Effects of partial liquid ventilation with perfluorodecalin in the juvenile rabbit lung after saline injury [25].
• Perfluorodecalin emulsions formed with Butronic U-1 were stable during the 4-hr perfusions but not during long-term storage [2].
• Intravenous infusion of emulsified perfluorodecalin in rats caused a large increase in hepatic cytochrome P-450 concentration which persisted for many weeks [26].
• Following incubation with hypericin, RT-112 TCC spheroids were irradiated in the presence or absence of perfluorodecalin, at light doses of 7 J/cm(2) or 28 J/cm(2) , delivered at a fluence rate of 15 mW/cm(2) . The photodynamic therapy (PDT) efficacy was evaluated and apoptotic cells were visualized [4].
• Effects of high oxygen concentrations on microbial biosensor signals. Hyperoxygenation by means of perfluorodecalin [27].

References