Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

Oxynicotine 3-[(2S)-1-methyl-1-oxido- 2,3,4,5...

Synonyms: N-Oxynicotine, CPD-2743, CCRIS 7627, AG-L-62690, LS-96507, ...

Xu, X. et al., Nakayama, H. et al., Duan, M.J. et al., Sindelar, R.D. et al.

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High impact information on CCRIS 7627

METHODS: We developed a sensitive method for analysis of nicotine and five major nicotine metabolites, including cotinine, trans-3'-hydroxycotinine, nicotine-N'-oxide, cotinine-N-oxide, and nornicotine, in human urine by liquid chromatography coupled with a TSQ Quantum triple quadrupole tandem mass spectrometer (LC/MS/MS) [1].
These results show that microsomal electron transport systems participate in the formation of nicotine-1'-oxide and strongly suggest the involvement of FAD-containing monooxygenase in the formation of nicotine-1'-oxide [2].
N-demethylation of nicotine and reduction of nicotine-1'-N-oxide by Microsporum gypseum [3].
The disposition kinetics of nicotine-1'-N-oxide were characterized in New Zealand rabbits [4].

Biological context of CCRIS 7627

Disposition kinetics and metabolism of nicotine-1'-N-oxide in rabbits [4].

References

Simultaneous and sensitive measurement of anabasine, nicotine, and nicotine metabolites in human urine by liquid chromatography-tandem mass spectrometry. Xu, X., Iba, M.M., Weisel, C.P. Clin. Chem. (2004) [Pubmed]
Formation of two major nicotine metabolites in livers of guinea pigs. Nakayama, H., Fujihara, S., Nakashima, T., Kurogochi, Y. Biochem. Pharmacol. (1987) [Pubmed]
N-demethylation of nicotine and reduction of nicotine-1'-N-oxide by Microsporum gypseum. Sindelar, R.D., Rosazza, J.P., Barfknecht, C.F. Appl. Environ. Microbiol. (1979) [Pubmed]
Disposition kinetics and metabolism of nicotine-1'-N-oxide in rabbits. Duan, M.J., Yu, L., Savanapridi, C., Jacob, P., Benowitz, N.L. Drug Metab. Dispos. (1991) [Pubmed]

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