Disease relevance of Microsporum

• An excellent antimycotic activity of terbinafine was also demonstrable after topical treatment of guinea pig dermatophytoses caused by Trichophyton mentagrophytes or Microsporum canis [1].
• OBJECTIVE: (i) To establish the optimal duration for terbinafine treatment to bring about complete cure of tinea capitis due to Microsporum infection in a large paediatric population, and (ii) to obtain information on the maximum therapeutic effect of the existing therapy [2].
• Onychomycosis caused by Microsporum canis: treatment with itraconazole [3].
• Granuloma and pseudogranuloma of the skin due to Microsporum canis. Successful management with local injections of miconazole [4].
• Miconazole nitrate 2% was tested for its efficacy against Microsporum gallinae (the causative agent in favus) in a flock of various Oriental breed (Shamo and Aseel) and crossbreed chickens [5].

High impact information on Microsporum

• Expression of ubiquitin gene in Microsporum canis and Trichophyton mentagrophytes cultured with fluconazole [6].
• Naftifine, a new antifungal agent belonging chemically to the allylamines, was tested for its in vivo activity after topical application against guinea pig skin infections caused by Trichophyton mentagrophytes, T. mentagrophytes var. quinckeanum, or Microsporum racemosum [7].
• By using ethylene glycol extraction of whole submerged cultures followed by Sephadex G-200 and diethylaminoethyl-Sephadex chromatography, we isolated four distinct glycopeptides from Trichophyton mentagrophytes, T. rubrum, and Microsporum canis [8].
• However, PCZ showed a more potent fungicidal activity than that of ITC against isolates belonging to the genus Microsporum (P = 0.03) [9].
• N-demethylation of nicotine and reduction of nicotine-1'-N-oxide by Microsporum gypseum [10].

Chemical compound and disease context of Microsporum

• Once-weekly fluconazole in children with tinea capitis due to Microsporum canis [11].
• We present the case of a 16-day-old infant with tinea capitis caused by Microsporum canis and effectively treated with topical bifonazole 1% [12].
• L-Cysteine hydrochloride exhibited absolute toxicity against both the test pathogens while DL-aspartic acid was found active against Microsporum gypseum only [13].

Biological context of Microsporum

• Here we report the effect of fluconazole on the sulphur metabolism negative regulator gene (sconC) in Microsporum canis [14].
• In the present study, the nucleotide sequences of the CHS1 gene from dermatophytes and related fungi in the genera Chrysosporium, Epidermophyton, Microsporum and Trichophyton were investigated using molecular methods [15].
• Evaluation of Fungicidal Efficacy of Benzalkonium Chloride (Steramina G u.v.) and Virkon-S against Microsporum canis for Environmental Disinfection [16].

Associations of Microsporum with chemical compounds

• Five microorganisms including Microsporum gypseum (ATCC 11395) produced nornicotine and three unknown metabolites [10].
• By contrast, there was a better response to griseofulvin than to terbinafine in patients with Microsporum audouinii infections [17].
• Cystine catabolism in mycelia of Microsporum gypseum, a dermatophytic fungus [18].
• Effect of choline, ethanolamine and serine supplementation on the membrane properties of Microsporum gypseum [19].
• Supplementation of glucose-containing medium with ethanol and replacement of glucose by glycerol in the Sabouraud's growth medium of Microsporum gypseum altered the levels of total phospholipids as well as their apolar and polar head groups [20].

Gene context of Microsporum

• The molecular taxonomy of the CHS1 gene sequences revealed that Microsporum was genetically distinct from Chrysosporium and Trichophyton, as classified by morphological characteristics [15].
• A 25-year-old immunosuppressed woman with systemic lupus erythematosus experienced a chronic cutaneous and subcutaneous infection due to Microsporum canis [4].
• Glycerol kinase, the key enzyme for glycerol use in phospholipid synthesis, was identified in cytosolic fractions of 2 dermatophytes, Microsporum gypseum and Epidermophyton floccosum [21].
• Isolation, purification and characterization of keratinolytic proteinase from Microsporum canis [22].
• Identification, localization and possible role of calmodulin like protein in phospholipid synthesis of Microsporum gypseum [23].

Analytical, diagnostic and therapeutic context of Microsporum

• To evaluate the efficacy of itraconazole and griseofulvin in the treatment of Microsporum canis infection, 15 juvenile cats were infected by topical application of 10(5) live M canis macroconidia to the skin of the lateral part of the trunk, and an occlusive bandage was applied [24].
• Efficacy of oral administration of itraconazole to cats with dermatophytosis caused by Microsporum canis [25].
• A keratinolytic protease, secreted as the major component by a feline clinical isolate of Microsporum canis cultivated in a minimal medium containing cat keratin, was purified by affinity chromatography on bacitracin agarose and gel filtration [26].
• Low voltage scanning electron microscopy study of naftifine activity on Microsporum canis [27].
• The Microsporum canis morphology alterations induced by naftifine at a concentration of 0.9 microgram ml-1 (10 times the minimum inhibitory concentration (MIC) for 7 days were studied in LVSEM [27].

References