Disease relevance of NSC 348407

• Morphology of noncardiogenic pulmonary edema induced by Perilla ketone in sheep [1].
• It is assumed that perilla ketone toxicity in ponies produces a restrictive disease without a significant obstructive component [2].
• Perilla ketone was assessed for its usefulness as a model of equine restrictive pulmonary disease [2].
• Perilla ketone increases pulmonary microvascular permeability without changing filling pressures and is used to induce a model of human ARDS [3].

High impact information on NSC 348407

• Treatment for 3.5 h with Pla (n = 9) and PK (n = 11) each significantly lessened the histamine dose required to cause a fall to 65% of baseline dynamic lung compliance (ED65Cdyn), i.e., increased responsiveness [4].
• Perilla ketone (PK) is a potent lung toxin that causes increased microvascular permeability pulmonary edema in grazing animals [5].
• Perilla ketone increases endothelial cell monolayer permeability in vitro [5].
• The 48-h LD50 (i.p.) in Notre Dame Swiss mice for each analog was greater than that of the parent toxicant, perilla ketone (1, 30 +/- 5; 2, 173 +/- 4; 3, 150 +/- 11; 4, 79 +/- 5 mumol/kg) [6].
• To explore a possible relationship between metabolism and lethality, the acute toxicity of naturally occurring perilla ketone (PK), 1-(3-furyl)-4-methyl-pentan-1-one, was examined in the uninduced mouse, hamster, rabbit, dog and pig [7].

Gene context of NSC 348407

• Results: Both upward arrowP(LA) and PK were associated with statistically significant tracheal narrowing ( upward arrowP(LA): 20.3 +/- 0.6 to 15.1 +/- 0.9 mm; PK: 20.2 +/- 0.6 to 14.1 +/- 1.4 mm) [8].

Analytical, diagnostic and therapeutic context of NSC 348407

• Noncardiogenic pulmonary edema was induced by intravenous infusion of Perilla ketone (PK) [9].
• Plasma and lymph samples were collected before and after PK administration and analyzed for dextran and protein concentrations after high-performance liquid chromatography size separation [10].

References