Disease relevance of NSC 50718

• The detection in urine of compounds such as 7-methylguanine and 1-methylguanine, and their increase in the urine of colorectal tumor bearing patients, has been justified either by a more rapid turnover of nucleic acids in tumor tissue or by an increase in the extent of their methylation [1].

High impact information on NSC 50718

• All seven 1-methylguanine-transformed cell lines were hyperdiploid with a modal chromosome number of 23 [2].
• Altered growth properties of Chinese hamster cells exposed to 1-methylguanine and 7-methylguanine [3].
• In particular, N1-methylguanine methylation is much greater in the methyl-deficient rat liver tRNA [4].
• The statistical view gained through the MMD strategy allowed us to characterize the hydration patterns around important RNA structural motifs such as a G-U base-pair, the anticodon U-turn, and two modified bases: pseudouridine and 1-methylguanine [5].
• The contributions of the 1-methylguanine and the 7-methylguanine specific enzymes fell to a few percent of the total by late S phase [6].

Biological context of NSC 50718

• 6. One of these cell lines was also tumorigenic in nude mice, Specific cytogenetic changes were observed in most 1-methylguanine-transformed populations in contrast to the karyotypic heterogeneity of a benzo[a]pyrene-transformed cell line [2].

Analytical, diagnostic and therapeutic context of NSC 50718

• Chinese hamster embryo cells transformed with the tRNA catabolite 1-methylguanine were characterized by Giemsa-banded karyotyping and by their tumorigenic potency in athymic nude mice [2].

References