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Chemical Compound Review:

Amidonal N-(2,3-dihydro-1H-inden-2- yl)-N',N'...

Synonyms: Ritmusin, Aspenon, Fiboran, Aprindine HCl, Aspenon (TN), ...

This record was replaced with 2218.

Elharrar, V. et al., Strasberg, B. et al., Reid, P.R. et al., Yoshida, H. et al., Khan, A.H. et al., et al.

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Disease relevance of APRINDINE

Clinical use of aprindine hydrochloride is occasionally complicated by agranulocytosis [1].
Aprindine hydrochloride has been extensively used in Europe for the management of ventricular and supraventricular arrhythmias [2].
Because aprindine hydrochloride was effective in preventing ventricular tachycardias, we also tested the effect of the drug on WT HERG (I(Kr)) and KvLQT1/KCNE1 (I(Ks)) currents expressed in COS7 [3].
Aprindine hydrochloride is a potent antiarrhythmic agent against various atrial and ventricular tachyarrhythmias [4].
Four patients with supraventricular tachycardia associated with the Wolff-Parkinson-White syndrome were refractory to conventional pharmacological therapy and received aprindine hydrochloride intravenously and orally [5].

High impact information on APRINDINE

The electrophysiologic effects of aprindine hydrochloride were studied on normal Purkinje fibers, on Purkinje fibers superfused with Tyrode's solution containing 22 mM KCl and isoproterenol (1 X 10(-5) M) and on transient depolarizations induced by exposure to acetylstrophanthidin (1.7--2 X 10(-7) M) [6].
Aprindine hydrochloride was administered IV and orally to 20 dogs with ventricular tachycardia [7].
Non-linear pharmacokinetics of aprindine hydrochloride in oral administration [8].

Analytical, diagnostic and therapeutic context of APRINDINE

Aprindine hydrochloride is an antiarrhythmic agent presently undergoing clinical trials in the United States. Because of the narrow therapeutic-toxic ratio observed for aprindine, the long-term follow-up of these patients is important in determining the potential clinical effectiveness of this drug [9].

References

Aprindine-induced agranulocytosis. Evidence for immunologic mechanism. Pisciotta, A.V., Cronkite, C. Arch. Intern. Med. (1983) [Pubmed]
Aprindine therapy for refractory ventricular tachycardia. Khan, A.H., Carleton, R.A., Chown, M. Arch. Intern. Med. (1983) [Pubmed]
Characterization of a novel missense mutation in the pore of HERG in a patient with long QT syndrome. Yoshida, H., Horie, M., Otani, H., Takano, M., Tsuji, K., Kubota, T., Fukunami, M., Sasayama, S. J. Cardiovasc. Electrophysiol. (1999) [Pubmed]
Electrophysiologic actions of aprindine in rabbit atrioventricular node. Tanaka, H., Nishimura, M., Homma, N., Habuchi, Y., Watanabe, Y. Naunyn Schmiedebergs Arch. Pharmacol. (1990) [Pubmed]
Suppression of refractory arrhythmias by aprindine in patients with the Wolff-Parkinson-White syndrome. Reid, P.R., Greene, H.L., Varghese, P.J. British heart journal. (1977) [Pubmed]
Effects of aprindine HCl on slow channel action potentials and transient depolarizations in canine Purkinje fibers. Elharrar, V., Bailey, J.C., Lathrop, D.A., Zipes, D.P. J. Pharmacol. Exp. Ther. (1978) [Pubmed]
Aprindine for treatment of ventricular arrhythmias in the dog. Muir, W.W., Bonagura, J.D. Am. J. Vet. Res. (1982) [Pubmed]
Non-linear pharmacokinetics of aprindine hydrochloride in oral administration. Yokota, M., Inagaki, H., Uematsu, H., Enomoto, N., Goto, J., Sotobata, I., Takahashi, A. Arzneimittel-Forschung. (1987) [Pubmed]
Long-term follow-up of patients receiving aprindine. Safety and efficacy. Strasberg, B., Prechel, D., Bauman, J., Coelho, A., Swiryn, S., Bauernfeind, R., Rosen, K.M. Arch. Intern. Med. (1983) [Pubmed]

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