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Chemical Compound Review

Amidonal     N-(2,3-dihydro-1H-inden-2- yl)-N',N'...

Synonyms: Ritmusin, Aspenon, Fiboran, Aprindine HCl, Aspenon (TN), ...
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Disease relevance of APRINDINE


High impact information on APRINDINE


Analytical, diagnostic and therapeutic context of APRINDINE

  • Aprindine hydrochloride is an antiarrhythmic agent presently undergoing clinical trials in the United States. Because of the narrow therapeutic-toxic ratio observed for aprindine, the long-term follow-up of these patients is important in determining the potential clinical effectiveness of this drug [9].


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  2. Aprindine therapy for refractory ventricular tachycardia. Khan, A.H., Carleton, R.A., Chown, M. Arch. Intern. Med. (1983) [Pubmed]
  3. Characterization of a novel missense mutation in the pore of HERG in a patient with long QT syndrome. Yoshida, H., Horie, M., Otani, H., Takano, M., Tsuji, K., Kubota, T., Fukunami, M., Sasayama, S. J. Cardiovasc. Electrophysiol. (1999) [Pubmed]
  4. Electrophysiologic actions of aprindine in rabbit atrioventricular node. Tanaka, H., Nishimura, M., Homma, N., Habuchi, Y., Watanabe, Y. Naunyn Schmiedebergs Arch. Pharmacol. (1990) [Pubmed]
  5. Suppression of refractory arrhythmias by aprindine in patients with the Wolff-Parkinson-White syndrome. Reid, P.R., Greene, H.L., Varghese, P.J. British heart journal. (1977) [Pubmed]
  6. Effects of aprindine HCl on slow channel action potentials and transient depolarizations in canine Purkinje fibers. Elharrar, V., Bailey, J.C., Lathrop, D.A., Zipes, D.P. J. Pharmacol. Exp. Ther. (1978) [Pubmed]
  7. Aprindine for treatment of ventricular arrhythmias in the dog. Muir, W.W., Bonagura, J.D. Am. J. Vet. Res. (1982) [Pubmed]
  8. Non-linear pharmacokinetics of aprindine hydrochloride in oral administration. Yokota, M., Inagaki, H., Uematsu, H., Enomoto, N., Goto, J., Sotobata, I., Takahashi, A. Arzneimittel-Forschung. (1987) [Pubmed]
  9. Long-term follow-up of patients receiving aprindine. Safety and efficacy. Strasberg, B., Prechel, D., Bauman, J., Coelho, A., Swiryn, S., Bauernfeind, R., Rosen, K.M. Arch. Intern. Med. (1983) [Pubmed]
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