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Chemical Compound Review

KST-1A6612     [(3S,5S,10R,13R,14S,17S)- 5,14-dihydroxy-10...

Synonyms: AC1L1LPX, LS-52487, AR-1A5280, NSC 92954, 60-38-8, ...
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Disease relevance of NSC 92954


High impact information on NSC 92954


Chemical compound and disease context of NSC 92954


Biological context of NSC 92954


Anatomical context of NSC 92954


Associations of NSC 92954 with other chemical compounds


Gene context of NSC 92954

  • We conclude that the acute inotropic effects of DIG, ACS and OUA (and the effects on RyRs) depend on the presence of Na(+) and a functional NCX in ferret and cat myocytes (rather than alternate Na(+)-independent mechanisms) [20].

Analytical, diagnostic and therapeutic context of NSC 92954


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  2. Diminished inotropic responses but unaltered toxicity to acetylstrophanthidin in the senescent beagle. Guarnieri, T., Spurgeon, H., Forehlich, J.P., Weisfeldt, M.L., Lakatta, E.G. Circulation (1979) [Pubmed]
  3. Glycoside inotropy in the absence of an increase in potassium efflux in the rabbit heart. Poole-Wilson, P.A., Langer, G.A. Circ. Res. (1975) [Pubmed]
  4. Differential effects of procainamide, lidocaine and acetylstrophanthidin on body surface potentials and epicardial conduction in dogs with chronic myocardial infarction. de Langen, C.D., Hanich, R.F., Michelson, E.L., Kadish, A.H., Levine, J.H., Balke, C.W., Spear, J.F., Moore, E.N. J. Am. Coll. Cardiol. (1988) [Pubmed]
  5. Peripheral arterial and venous responses to acetylstrophanthidin in patients with acute myocardial infarction. Creager, M.A., Halperin, J.L., Klein, M.D., Coffman, J.D. Clin. Pharmacol. Ther. (1982) [Pubmed]
  6. Neurogenic coronary vasoconstrictor effects of digitalis during acute global ischemia in dogs. Sagar, K.B., Hanson, E.C., Powell, W.J. J. Clin. Invest. (1977) [Pubmed]
  7. Mechanism by which metabolic inhibitors depolarize cultured cardiac cells. Clusin, W.T. Proc. Natl. Acad. Sci. U.S.A. (1983) [Pubmed]
  8. A possible role for endogenous prostaglandins in the electrophysiological effects of acetylstrophanthidin on isolated canine ventricular tissues. Moffat, M.P., Ferrier, G.R., Karmazyn, M. Circ. Res. (1986) [Pubmed]
  9. Cumulative depletions of extracellular calcium in rabbit ventricular muscle monitored with calcium-selective microelectrodes. Bers, D.M., MacLeod, K.T. Circ. Res. (1986) [Pubmed]
  10. The effects of acetylstrophanthidin and ouabain on the sympathetic adrenergic neuroeffector junction in canine vascular smooth muscle. Lorenz, R.R., Powis, D.A., Vanhoutte, P.M., Shepherd, J.T. Circ. Res. (1980) [Pubmed]
  11. Cardiac effect of diuretic drugs. Seller, R.H., Banach, S., Namey, T., Neff, M., Swartz, C. Am. Heart J. (1975) [Pubmed]
  12. Ischemic heart failure: sustained inotropic response to small doses of I-epinephrine without toxicity. Haider, B., Khan, M.I., Burke, W.M., Regan, T.J. Am. J. Cardiol. (1975) [Pubmed]
  13. The effect of intracoronary lidocaine infusion on acetylstrophanthidin-induced ventricular arrhythmia in dogs. Tordjman, T., Lampert, S., Lown, B. Pharmacotherapy (1988) [Pubmed]
  14. Arrhythmogenic dose of acetylstrophanthidin unchanged by beta-sympathomimetics in conscious dogs. Haass, M., Sponer, G., Abshagen, U. Basic Res. Cardiol. (1984) [Pubmed]
  15. Acetylcholine-induced reversal of canine and feline atrial myocardial depression during stretch, cardiac failure, and drug toxicity. Gelband, H., Myerburg, R.J., Hoffman, B.F., Bassett, A.L. Circ. Res. (1975) [Pubmed]
  16. Acetylstrophanthidin-induced reflex inhibition of canine renal sympathetic nerve activity mediated by cardiac receptors with vagal afferents. Thames, M.D. Circ. Res. (1979) [Pubmed]
  17. Influence of calcium concentration on the rate of onset of cardiac glycoside and aglycone inotropism. Park, M.K., Vincenzi, F.F. J. Pharmacol. Exp. Ther. (1976) [Pubmed]
  18. Interaction between ion transporters and the mucociliary transport system in dog and baboon. Winters, S.L., Yeates, D.B. J. Appl. Physiol. (1997) [Pubmed]
  19. Relationship between acetylstrophanthidin-induced aftercontractions and the strength of contraction of canine ventricular myocardium. Ferrier, G.R. Circ. Res. (1977) [Pubmed]
  20. The inotropic effect of cardioactive glycosides in ventricular myocytes requires Na+-Ca2+ exchanger function. Altamirano, J., Li, Y., Desantiago, J., Piacentino, V., Houser, S.R., Bers, D.M. J. Physiol. (Lond.) (2006) [Pubmed]
  21. Effect of lithium and of other drugs used in the treatment of manic illness on the cation-transporting properties of Na+,K+-ATPase in mouse brain synaptosomes. Wood, A.J., Elphick, M., Grahame-Smith, D.G. J. Neurochem. (1989) [Pubmed]
  22. Effects of alpha-adrenergic agents on transient inward current in rabbit Purkinje fibers. Ferrier, G.R., Carmeliet, E. J. Mol. Cell. Cardiol. (1990) [Pubmed]
  23. Acetylcholine antagonism of the electrophysiological effects of isoproterenol on canine cardiac Purkinje fibers. Bailey, J.C., Watanabe, A.M., Besch, H.R., Lathrop, D.A. Circ. Res. (1979) [Pubmed]
  24. The relationship between cardiotoxicity and plasma digoxin concentration in conscious dogs. Chapple, D.J., Hughes, R., Johnson, B.F. Br. J. Pharmacol. (1976) [Pubmed]
  25. Rate of onset of cardiotonic steroid-induced inotropism: influence of temperature and beat interval. Park, M.K., Vincenzi, F.F. J. Pharmacol. Exp. Ther. (1975) [Pubmed]
  26. Alpha 2-adrenoceptor blockade prevents cardiac glycoside-evoked neurotransmitter release from sympathetic nerves in dog saphenous vein. Powis, D.A. Br. J. Pharmacol. (1987) [Pubmed]
  27. Cesium chloride-induced long QT syndrome: demonstration of afterdepolarizations and triggered activity in vivo. Levine, J.H., Spear, J.F., Guarnieri, T., Weisfeldt, M.L., de Langen, C.D., Becker, L.C., Moore, E.N. Circulation (1985) [Pubmed]
  28. Ischemic-induced alterations in cardiac sensitivity to digitalis. Ku, D.D., Lucchesi, B.R. Eur. J. Pharmacol. (1979) [Pubmed]
  29. Chronotropic effect of acetylstrophanthidin infusion into the canine sinus nodal artery. Geer, M.R., Wagner, G.S., Waxman, M., Wallace, A.G. Am. J. Cardiol. (1977) [Pubmed]
  30. The effect of acetylstrophanthidin on the responsiveness of left atrial type B receptors to saline infusion and veratrine injection in anaesthetized cats. Fahim, M., Ravi, K. Pflugers Arch. (1986) [Pubmed]
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