Gene Review:
KCNE1 - potassium channel, voltage gated subfamily...
Homo sapiens
Synonyms:
Delayed rectifier potassium channel subunit IsK, IKs producing slow voltage-gated potassium channel subunit beta Mink, ISK, JLNS, JLNS2, ...
Splawski,
Shen,
Timothy,
Lehmann,
Priori,
Robinson,
Moss,
Schwartz,
Towbin,
Vincent,
Keating,
McDonald,
Yu,
Ming,
Palma,
Meyers,
Wang,
Goldstein,
Fishman,
Wangemann,
Möller,
Netzer,
Bendahhou,
Marionneau,
Haurogne,
Larroque,
Derand,
Szuts,
Escande,
Demolombe,
Barhanin,
Decher,
Bundis,
Vajna,
Steinmeyer,
- Mutations in the hminK gene cause long QT syndrome and suppress IKs function. Splawski, I., Tristani-Firouzi, M., Lehmann, M.H., Sanguinetti, M.C., Keating, M.T. Nat. Genet. (1997)
- Human congenital long QT syndrome: more than previously thought? Attali, B. Trends Pharmacol. Sci. (2002)
- Spectrum of mutations in long-QT syndrome genes. KVLQT1, HERG, SCN5A, KCNE1, and KCNE2. Splawski, I., Shen, J., Timothy, K.W., Lehmann, M.H., Priori, S., Robinson, J.L., Moss, A.J., Schwartz, P.J., Towbin, J.A., Vincent, G.M., Keating, M.T. Circulation (2000)
- Molecular genetics of long-QT syndrome. Wattanasirichaigoon, D., Beggs, A.H. Curr. Opin. Pediatr. (1998)
- Ménière's disease is associated with single nucleotide polymorphisms in the human potassium channel genes, KCNE1 and KCNE3. Doi, K., Sato, T., Kuramasu, T., Hibino, H., Kitahara, T., Horii, A., Matsushiro, N., Fuse, Y., Kubo, T. ORL J. Otorhinolaryngol. Relat. Spec. (2005)
- KCNE1 mutations cause jervell and Lange-Nielsen syndrome. Schulze-Bahr, E., Wang, Q., Wedekind, H., Haverkamp, W., Chen, Q., Sun, Y., Rubie, C., Hördt, M., Towbin, J.A., Borggrefe, M., Assmann, G., Qu, X., Somberg, J.C., Breithardt, G., Oberti, C., Funke, H. Nat. Genet. (1997)
- The conduction pore of a cardiac potassium channel. Tai, K.K., Goldstein, S.A. Nature (1998)
- A minK-HERG complex regulates the cardiac potassium current I(Kr). McDonald, T.V., Yu, Z., Ming, Z., Palma, E., Meyers, M.B., Wang, K.W., Goldstein, S.A., Fishman, G.I. Nature (1997)
- Disease-associated mutations in KCNE potassium channel subunits (MiRPs) reveal promiscuous disruption of multiple currents and conservation of mechanism. Abbott, G.W., Goldstein, S.A. FASEB J. (2002)
- Characterization of a novel Long QT syndrome mutation G52R-KCNE1 in a Chinese family. Ma, L., Lin, C., Teng, S., Chai, Y., Bähring, R., Vardanyan, V., Li, L., Pongs, O., Hui, R. Cardiovasc. Res. (2003)
- Characterization of a novel missense mutation in the pore of HERG in a patient with long QT syndrome. Yoshida, H., Horie, M., Otani, H., Takano, M., Tsuji, K., Kubota, T., Fukunami, M., Sasayama, S. J. Cardiovasc. Electrophysiol. (1999)
- Impaired KCNQ1-KCNE1 and phosphatidylinositol-4,5-bisphosphate interaction underlies the long QT syndrome. Park, K.H., Piron, J., Dahimene, S., Mérot, J., Baró, I., Escande, D., Loussouarn, G. Circ. Res. (2005)
- Altered potassium balance and aldosterone secretion in a mouse model of human congenital long QT syndrome. Arrighi, I., Bloch-Faure, M., Grahammer, F., Bleich, M., Warth, R., Mengual, R., Drici, M.D., Barhanin, J., Meneton, P. Proc. Natl. Acad. Sci. U.S.A. (2001)
- Requirement of subunit expression for cAMP-mediated regulation of a heart potassium channel. Kurokawa, J., Chen, L., Kass, R.S. Proc. Natl. Acad. Sci. U.S.A. (2003)
- Functional expression of two KvLQT1-related potassium channels responsible for an inherited idiopathic epilepsy. Yang, W.P., Levesque, P.C., Little, W.A., Conder, M.L., Ramakrishnan, P., Neubauer, M.G., Blanar, M.A. J. Biol. Chem. (1998)
- Atrial fibrillation-associated minK38G/S polymorphism modulates delayed rectifier current and membrane localization. Ehrlich, J.R., Zicha, S., Coutu, P., Hébert, T.E., Nattel, S. Cardiovasc. Res. (2005)
- Single nucleotide polymorphism map of five long-QT genes. Aydin, A., Bähring, S., Dahm, S., Guenther, U.P., Uhlmann, R., Busjahn, A., Luft, F.C. J. Mol. Med. (2005)
- Genomic structure of three long QT syndrome genes: KVLQT1, HERG, and KCNE1. Splawski, I., Shen, J., Timothy, K.W., Vincent, G.M., Lehmann, M.H., Keating, M.T. Genomics (1998)
- Functional modulation of the transient outward current Ito by KCNE beta-subunits and regional distribution in human non-failing and failing hearts. Radicke, S., Cotella, D., Graf, E.M., Banse, U., Jost, N., Varró, A., Tseng, G.N., Ravens, U., Wettwer, E. Cardiovasc. Res. (2006)
- Expression of multiple KCNE genes in human heart may enable variable modulation of I(Ks). Lundquist, A.L., Manderfield, L.J., Vanoye, C.G., Rogers, C.S., Donahue, B.S., Chang, P.A., Drinkwater, D.C., Murray, K.T., George, A.L. J. Mol. Cell. Cardiol. (2005)
- K(+) cycling and its regulation in the cochlea and the vestibular labyrinth. Wangemann, P. Audiol. Neurootol. (2002)
- Regulation of KCNE1-dependent K(+) current by the serum and glucocorticoid-inducible kinase (SGK) isoforms. Embark, H.M., Böhmer, C., Vallon, V., Luft, F., Lang, F. Pflugers Arch. (2003)
- TEA(+)-sensitive KCNQ1 constructs reveal pore-independent access to KCNE1 in assembled I(Ks) channels. Kurokawa, J., Motoike, H.K., Kass, R.S. J. Gen. Physiol. (2001)
- Characterization of recombinant human cardiac KCNQ1/KCNE1 channels (I (Ks)) stably expressed in HEK 293 cells. Dong, M.Q., Lau, C.P., Gao, Z., Tseng, G.N., Li, G.R. J. Membr. Biol. (2006)
- Effects of estradiol on cardiac ion channel currents. Möller, C., Netzer, R. Eur. J. Pharmacol. (2006)
- In vitro molecular interactions and distribution of KCNE family with KCNQ1 in the human heart. Bendahhou, S., Marionneau, C., Haurogne, K., Larroque, M.M., Derand, R., Szuts, V., Escande, D., Demolombe, S., Barhanin, J. Cardiovasc. Res. (2005)
- Functional coassembly of KCNQ4 with KCNE-beta- subunits in Xenopus oocytes. Strutz-Seebohm, N., Seebohm, G., Fedorenko, O., Baltaev, R., Engel, J., Knirsch, M., Lang, F. Cell. Physiol. Biochem. (2006)
- KCNE5 induces time- and voltage-dependent modulation of the KCNQ1 current. Angelo, K., Jespersen, T., Grunnet, M., Nielsen, M.S., Klaerke, D.A., Olesen, S.P. Biophys. J. (2002)
- A recessive C-terminal Jervell and Lange-Nielsen mutation of the KCNQ1 channel impairs subunit assembly. Schmitt, N., Schwarz, M., Peretz, A., Abitbol, I., Attali, B., Pongs, O. EMBO J. (2000)
- KCNE2 confers background current characteristics to the cardiac KCNQ1 potassium channel. Tinel, N., Diochot, S., Borsotto, M., Lazdunski, M., Barhanin, J. EMBO J. (2000)
- Structural determinants of KvLQT1 control by the KCNE family of proteins. Melman, Y.F., Domènech, A., de la Luna, S., McDonald, T.V. J. Biol. Chem. (2001)
- An LQT mutant minK alters KvLQT1 trafficking. Krumerman, A., Gao, X., Bian, J.S., Melman, Y.F., Kagan, A., McDonald, T.V. Am. J. Physiol., Cell Physiol. (2004)
- KCNE2 modulates current amplitudes and activation kinetics of HCN4: influence of KCNE family members on HCN4 currents. Decher, N., Bundis, F., Vajna, R., Steinmeyer, K. Pflugers Arch. (2003)
- Functional effects of a KCNQ1 mutation associated with the long QT syndrome. Boulet, I.R., Raes, A.L., Ottschytsch, N., Snyders, D.J. Cardiovasc. Res. (2006)