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Chemical Compound Review:

sGQDJLPxbSKUP@ 2,3-dibromopropan-1-ol

Synonyms: Brominex 257, CCRIS 940, NSC-6203, NCI-C55436, D43050_ALDRICH, ...

Eustis, S.L. et al., Shirai, T. et al., Søderlund, E.J. et al., St John, L.E. et al.

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Disease relevance of CCRIS 940

Toxicity and carcinogenicity of 2,3-dibromo-1-propanol in F344/N rats and B6C3F1 mice [1].

High impact information on CCRIS 940

The promoting effects of nephrotoxic chemicals, folic acid (FA), N-(3,5-dichlorophenyl)succinimide (NDPS), 2,3-dibromo-1-propanol phosphate (Tris-BP), and basic lead acetate (LAB), on 2-(ethylnitrosamino)ethanol (EHEN)-induced renal carcinogenesis were examined in F344 rats [2].
In rats, neoplasms induced by 2,3-dibromo-1-propanol occurred in the skin, nasal mucosa, Zymbal's gland, oral mucosa, esophagus, forestomach, intestines, liver, kidney, mammary gland (females), clitoral gland (females), spleen (males), and mesothelium (males) [1].
Other bromopropyl-compounds were also mutagenic; 2,3-dibromopropene and 2,3-dibromopropionic acid were directly mutagenic, whereas 2,3-dibromopropanol and tris(2-bromopropyl)phosphate were weakly mutagenic after addition of liver microsomes and cofactors [3].
When the pure chemical was applied directly to the shaved skin of a rat, the hydrolysis product, 2,3-dibromopropanol (DBP), appeared in the urine [4].

References

Toxicity and carcinogenicity of 2,3-dibromo-1-propanol in F344/N rats and B6C3F1 mice. Eustis, S.L., Haseman, J.K., Mackenzie, W.F., Abdo, K.M. Fundamental and applied toxicology : official journal of the Society of Toxicology. (1995) [Pubmed]
Promotion of 2-(ethylnitrosamino)ethanol-induced renal carcinogenesis in rats by nephrotoxic compounds: positive responses with folic acid, basic lead acetate, and N-(3,5-dichlorophenyl)succinimide but not with 2,3-dibromo-1-propanol phosphate. Shirai, T., Ohshima, M., Masuda, A., Tamano, S., Ito, N. J. Natl. Cancer Inst. (1984) [Pubmed]
Mutagenic activation of tris(2,3-dibromopropyl)phosphate: the role of microsomal oxidative metabolism. Søderlund, E.J., Nelson, S.D., Dybing, E. Acta pharmacologica et toxicologica. (1979) [Pubmed]
Studies of possible absorption of a flame retardant from treated fabrics worn by rats and humans. St John, L.E., Eldefrawi, M.E., Lisk, D.J. Bulletin of environmental contamination and toxicology. (1976) [Pubmed]

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