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Chemical Compound Review:

CHEMBL1767 1,3,7-trimethyl-9H-purine- 2,6,8-trione

Synonyms: AG-F-87246, SureCN2037400, HMDB02123, CPD-12480, NSC-11259, ...

Rasmussen, B.B. et al., Ademola, J.I. et al., Bhat, V.B. et al., Nishida, Y.

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High impact information on Trimethyl uric acid

However, the variation in specific activities of the microsomes for the formation of 1,3,7-trimethyluric acid was twofold (range 2.8 +/- 0.1-6.2 +/- 0.5 pmol/min per mg protein) [1].
The present study has pointed out that it is possible to significantly enhance the antioxidant property of 1,3,7-trimethyluric acid by structural modification at N-1 position [2].
1,3-Dimethyluric acid and 1,3,7-trimethyluric acid showed high potency in prevention of lipid peroxidation [3].
The CYP3A4 inhibitors, ketoconazole and bromocriptine, inhibited 1,3,7-trimethyluric acid formation with Kis of 0.75 microM and 5 microM, respectively, thus further supporting the involvement of CYP3A4 in the 8-hydroxylation of caffeine [4].
A high-performance liquid chromatography method was developed in order to assay 1,3-dimethylxanthine, 1,7-dimethylxanthine, 3,7-dimethylxanthine and 1,3,7-trimethyluric acid formed from caffeine by human liver microsomes [4].

References

Cutaneous metabolism of theophylline by the human skin. Ademola, J.I., Wester, R.C., Maibach, H.I. J. Invest. Dermatol. (1992) [Pubmed]
Efficient scavenging of hydroxyl radicals and inhibition of lipid peroxidation by novel analogues of 1,3,7-trimethyluric acid. Bhat, V.B., Sridhar, G.R., Madyastha, K.M. Life Sci. (2001) [Pubmed]
Inhibition of lipid peroxidation by methylated analogues of uric acid. Nishida, Y. J. Pharm. Pharmacol. (1991) [Pubmed]
Fluvoxamine is a potent inhibitor of the metabolism of caffeine in vitro. Rasmussen, B.B., Nielsen, T.L., Brøsen, K. Pharmacol. Toxicol. (1998) [Pubmed]

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