Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

Restovar (8S,9S,13S,14S,17S)-3-ethyl- 17-ethynyl-13...

Synonyms: Lyndiol, Ovanon, Ovariostat, Noracycline, Sistometrenol, ...

Hussain, S.P. et al., Ecavade, A. et al., Mimori, H. et al., Creatsas, G. et al., Kabarity, A. et al., et al.

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Disease relevance of Sistometrenol

Ten adolescents with primary dysmenorrhea (PD) were treated with the oral contraceptive (OC) Lyndiol 2.5 mg (R) for one cycle [1].

High impact information on Sistometrenol

The present study reports the modulatory influences of combined oral contraceptive formulations, Ovral (0.05 mg ethinylestradiol plus 0.5 mg norgestrel per pill) and Noracycline (0.05 mg ethinylestradiol plus 0.1 mg lynestrenol per pill), on methylcholanthrene (MCA)-induced carcinogenesis in the uterine cervix of Swiss albino mouse [2].
On the other hand, Lyndiol induces minor abnormalities leaving the process of mitosis to proceed almost normally [3].
Each of the above groups received the progestogen Lyndiol (lynestrenol, 5.0 mg, and mestranol, 0.15 mg) daily for 7 days during the follicular phase of the menstrual cycle [4].
Hence, it may be concluded from the present study that the growth and development pattern of mammary epithelium can be modulated by treatment with oral contraceptives Oral, Noracycline, Pearl and Centchroman which is indicated by the increase in the diameters of TEBS and LBS [5].
We conclude that Lyndiol has no disease modifying effect in rheumatoid arthritis [6].

References

Prostaglandins: PGF2 alpha, PGE2, 6-keto-PGF1 alpha and TXB2 serum levels in dysmenorrheic adolescents before, during and after treatment with oral contraceptives. Creatsas, G., Deligeoroglou, E., Zachari, A., Loutradis, D., Papadimitriou, T., Miras, K., Aravantinos, D. Eur. J. Obstet. Gynecol. Reprod. Biol. (1990) [Pubmed]
Modulatory influence of oral contraceptive pills Ovral and Noracycline on 3-methylcholanthrene-induced carcinogenesis in the uterine cervix of mouse. Hussain, S.P., Rao, A.R. Jpn. J. Cancer Res. (1992) [Pubmed]
Further investigations on the cytological effects of some contraceptives. Kabarity, A., Mazrooei, S. Mutat. Res. (1984) [Pubmed]
Effect of progestogen on glycogen metabolism in the endometrium of infertile patients during the menstrual cycle. Mimori, H., Fukuma, K., Matsuo, I., Nakahara, K., Maeyama, M. Fertil. Steril. (1981) [Pubmed]
Modulatory influence of oral contraceptives on mammary growth pattern of normal and ovariectomised mice. Ecavade, A., Rao, A.R. Contraception. (1994) [Pubmed]
Oral contraceptive treatment for rheumatoid arthritis: an open study in 10 female patients. Hazes, J.M., Dijkmans, B.A., Vandenbroucke, J.P., Cats, A. Br. J. Rheumatol. (1989) [Pubmed]

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