Disease relevance of Ethinylestrenol

• Delay of tumor growth in hamsters treated with lynestrenol and effect of Staphylococcus aureus Cowan A [1].
• The action of lynestrenol, a synthetic progesterone-like substance, was studied in Syrian golden hamsters inoculated with cells transformed by herpes simplex virus type I. Daily ip injections of 1 mg lynesterol/kg delayed tumor growth [1].
• Effects of danazol and lynestrenol on serum lipoproteins in endometriosis [2].
• We studied the effect of a progestin (lynestrenol) on estrogen receptors (ER) and cathepsin D (cath-D) levels immunochemically in successive fine needle aspirates of benign breast disease [3].
• An assessment of (1) cyproterone acetate and (2) ethinyl oestradiol and lynoestrenol (Minilyn) in the treatment of idiopathic hirsutism [4].

Psychiatry related information on Ethinylestrenol

• When ovulation was inhibited by a combination of ethinylestradiol and lynestrenol, an oral contraceptive pill, the hypersomnia ceased [5].

High impact information on Ethinylestrenol

• However, E2DH stimulation by lynestrenol depended on receptor levels [6].
• The PRL response to TRH was blunted in patients before lynestrenol therapy [7].
• The treatment of endometriosis with danazol or lynestrenol decreased cholesterol content of plasma high-density lipoproteins by 50% and 32% [2].
• Thirty-one patients were treated with 10 mg of lynestrenol daily from the fifth to the twenty-fifth day of the menstrual cycle for 1 to 3 months [3].
• Female rats were treated with different doses of an oral contraceptive (ethinyl estradiol + lynestrenol) and lipid biosynthesis was studied in blood platelets by acetate incorporation into different fractions separated by thin layer chromatography [8].

Chemical compound and disease context of Ethinylestrenol

• Fourteen of the 23 patients with invasive adenocarcinomas and 9 patients with adenocarcinoma in situ had taken contraceptives containing a potent gestagen, Norgestrel; the others had taken either Norethisterone acetate or Lynestrenol, usually in relatively high doses [9].
• Prospective randomized study comparing the GnRH-agonist leuprorelin acetate and the gestagen lynestrenol in the treatment of severe endometriosis [10].
• One hundred thirty-two women between the ages of 19 and 50, with various forms of benign breast diseases received 1 mg promegestone, or 0.5 mg promegestone, or 10 mg lynestrenol daily (double-blind), for 15 days per cycle, during three cycles [11].
• Evaluation of preoperative use of danazol, gestrinone, lynestrenol, buserelin spray and buserelin implant, in the treatment of endometriosis associated infertility [12].
• In order to avoid secondary induction of estrogens caused by tamoxifen treatment, tamoxifen was associated with the progestative lynestrenol in 48 menstrual women with benign breast disease (adenoma or fibroadenoma, cystic, simple or complex dysplasia) [13].

Biological context of Ethinylestrenol

• Lynoestrenol did not affect the respiration or glycolysis of the spermatozoa, but did inhibit motility [14].
• Pregnant Belted Dutch rabbits were administered lynestrenol 17-alpha-ethynyl-oestr-4-en-17-beta-ol) orally on days 6-18 of gestation at doses of 0.1, 0.5, and 2.5 mg/kg/day [15].
• Ovarian morphology during and after lynestrenol treatment around menopause [16].
• Antiandrogen treatment with spironolactone and linestrenol decreases bone mineral density in eumenorrhoeic women with androgen excess [17].
• Of the progestogens structurally related to norethindrone, norethindrone acetate, ethynodiol diacetate, norethindrone enanthate, and perhaps lynestrenol, undergo rapid hydrolysis and are converted to the parent compound and its metabolites [18].

Anatomical context of Ethinylestrenol

• Women with inactive ovaries had uniformly low amounts of peritoneal fluid: 4.2 +/- 2.3 ml in 31 women taking combined oral contraceptive pills; 4.7 +/- 5.8 ml in 17 women taking 5 mg of lynoestrenol daily and 1.2 +/- 1.9 ml in 20 postmenopausal women with an inactive endometrium [19].
• Stimulating properties of lynestrenol on normal human blood T-lymphocytes and other leucocytes [20].
• A trial was carried out in 10 healthy women to study the effects of withdrawal of treatment with 0.5 mg lynestrenol per day, for 3 successive days during the pre-ovulatory phase, on the physiological properties of the cervical mucus, vaginal cytology and pituitary and ovarian functions [21].
• Lynestrenol administration produced a statistically significant increase in the number of post-implantation loss (p = 0.05) and in the average per cent of abnormal fetuses per dose group (63%, 66%, and 87% for the medicated group, versus 12% for the placebo group, p = 0.05) [15].
• Lynestrenol, an amplifier of lymphocyte stimulation [22].

Associations of Ethinylestrenol with other chemical compounds

• The results indicated that there is a direct and specific steroid effect on human spermatozoa, as some steroids such as progesterone, lynestrenol, and norethynodrel markedly inhibited sperm migration and motility, whereas other steroids such as estrone had no detectable effect on sperm migration and motility [23].
• The effect of various dosages of lynestrenol on the plasma levels of oestrogens and progesterone during the menstrual cycle in the rhesus monkey [24].
• SHBG concentration and MV were dose-dependently suppressed indicating an antiestrogenic or possibly androgenic effect of desogestrel and lynestrenol [25].
• Compared with matched controls, pure progestogens (Depo Provera and Orgametril) caused a moderate decrease of TG, HDL chol, and Apo A1, whereas estrogen-dominant oral contraceptives (Ortho Novum SQ) increased the same parameters [26].
• Dose halving of lynestrenol resulted in an increase in serum total testosterone (T) by 16% (p less than 0.05), sex-hormone binding globulin (SHBG) by 39% (p less than 0.01) and high-density lipoprotein cholesterol (HDL-C) by 28% (p less than 0.001) [27].

Gene context of Ethinylestrenol

• There was no statistically significant increase in SHBG with 50 microgram ethinyloestradiol/2.5 mg lynestrenol or 50 microgram ethinyloestradiol/3 mg norethisterone acetate combinations [28].
• Lynestrenol significantly decreased the percentage of ER stained cells [3].
• Prolactin-like immunoreactivity has been localized by an immunoenzymatic method in the decidual cells of the endometrium in cases of early (10 weeks) normal pregnancy, (12 weeks) molar pregnancy, (8--10 weeks) tubal pregnancy, and of a nonpregnant woman under progestogen (lynestrenol) treatment [29].
• For lynestrenol, however, a small but significant increase in prealbumin concentration indicated a weak androgenic/anabolic effect [25].
• Based on history and the findings on ultrasound, an endometriosis was diagnosed, and the LHRH agonist (nafarelin) was administered nasally in combination with lynestrenol [30].

Analytical, diagnostic and therapeutic context of Ethinylestrenol

• Fifty patients with moderate or severe endometriosis received 5 mg/day lynestrenol for 6 months prior to microsurgery [31].
• A 25-year-old woman who suffered from hemoptysis during her menstrual periods was at first treated with lynestrenol, but the hemoptysis recurred immediately after treatment [32].
• Bone mass and bone remodelling were measured radiogrammetrically in 39 peri-menopausal women who participated in an earlier cross-sectional study and continued to receive progestogen treatment, viz. lynestrenol, 5 mg daily, for 4.5 yr after the first assessment [33].
• Peroral lynestrenol and arterial disease in mentally retarded women. A case-control study based on autopsy findings [34].
• Effects of a progestogen-only pill (Exluton) and an intrauterine device (Multiload Cu250) on breastfeeding [35].

References