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Chemical Compound Review

Exluton     (8R,9S,10R,13S,14S,17S)-17- ethynyl-13...

Synonyms: Exlution, Exlutona, Exluten, Lynenol, Linesterol, ...
 
 
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Disease relevance of Ethinylestrenol

 

Psychiatry related information on Ethinylestrenol

 

High impact information on Ethinylestrenol

 

Chemical compound and disease context of Ethinylestrenol

 

Biological context of Ethinylestrenol

 

Anatomical context of Ethinylestrenol

  • Women with inactive ovaries had uniformly low amounts of peritoneal fluid: 4.2 +/- 2.3 ml in 31 women taking combined oral contraceptive pills; 4.7 +/- 5.8 ml in 17 women taking 5 mg of lynoestrenol daily and 1.2 +/- 1.9 ml in 20 postmenopausal women with an inactive endometrium [19].
  • Stimulating properties of lynestrenol on normal human blood T-lymphocytes and other leucocytes [20].
  • A trial was carried out in 10 healthy women to study the effects of withdrawal of treatment with 0.5 mg lynestrenol per day, for 3 successive days during the pre-ovulatory phase, on the physiological properties of the cervical mucus, vaginal cytology and pituitary and ovarian functions [21].
  • Lynestrenol administration produced a statistically significant increase in the number of post-implantation loss (p = 0.05) and in the average per cent of abnormal fetuses per dose group (63%, 66%, and 87% for the medicated group, versus 12% for the placebo group, p = 0.05) [15].
  • Lynestrenol, an amplifier of lymphocyte stimulation [22].
 

Associations of Ethinylestrenol with other chemical compounds

 

Gene context of Ethinylestrenol

 

Analytical, diagnostic and therapeutic context of Ethinylestrenol

References

  1. Delay of tumor growth in hamsters treated with lynestrenol and effect of Staphylococcus aureus Cowan A. Wybran, J., Thiry, L. J. Natl. Cancer Inst. (1978) [Pubmed]
  2. Effects of danazol and lynestrenol on serum lipoproteins in endometriosis. Mälkönen, M., Manninen, V., Hirvonen, E. Clin. Pharmacol. Ther. (1980) [Pubmed]
  3. Progestin treatment depresses estrogen receptor but not cathepsin D levels in needle aspirates of benign breast disease. Maudelonde, T., Lavaud, P., Salazar, G., Laffargue, F., Rochefort, H. Breast Cancer Res. Treat. (1991) [Pubmed]
  4. An assessment of (1) cyproterone acetate and (2) ethinyl oestradiol and lynoestrenol (Minilyn) in the treatment of idiopathic hirsutism. Anderson, J.A. Br. J. Dermatol. (1978) [Pubmed]
  5. Menstruation-related periodic hypersomnia: a case study with successful treatment. Sachs, C., Persson, H.E., Hagenfeldt, K. Neurology (1982) [Pubmed]
  6. Estradiol 17 beta-hydroxysteroid dehydrogenase, a marker of breast cancer hormone dependency. Fournier, S., Brihmat, F., Durand, J.C., Sterkers, N., Martin, P.M., Kuttenn, F., Mauvais-Jarvis, P. Cancer Res. (1985) [Pubmed]
  7. In vivo effects of progestins on prolactin secretion. Sitruk-Ware, R., Varin, C., Clair, F., Maugis, E., Fermanian, J., Mauvais-Jarvis, P. J. Clin. Endocrinol. Metab. (1985) [Pubmed]
  8. Oral contraceptive and Platelet lipid biosynthesis in female rats: dose-response relationship. Ciavatti, M., Davenas, E., Michel, G., Renaud, S. Lipids (1982) [Pubmed]
  9. On the origin and histological structure of adenocarcinoma of the endocervix in women under 50 years of age. Dallenbach-Hellweg, G. Pathol. Res. Pract. (1984) [Pubmed]
  10. Prospective randomized study comparing the GnRH-agonist leuprorelin acetate and the gestagen lynestrenol in the treatment of severe endometriosis. Regidor, P.A., Regidor, M., Schmidt, M., Ruwe, B., Lübben, G., Förtig, P., Kienle, E., Schindler, A.E. Gynecol. Endocrinol. (2001) [Pubmed]
  11. Double-blind trial of promegestone (R 5020) and lynestrenol in the treatment of benign breast disease. Uzan, S., Denis, C., Pomi, V., Varin, C. Eur. J. Obstet. Gynecol. Reprod. Biol. (1992) [Pubmed]
  12. Evaluation of preoperative use of danazol, gestrinone, lynestrenol, buserelin spray and buserelin implant, in the treatment of endometriosis associated infertility. Donnez, J., Nisolle, M., Clerckx, F., Casanas, F. Prog. Clin. Biol. Res. (1990) [Pubmed]
  13. Combined tamoxifen-lynestrenol treatment in benign breast disease. Cupceancu, B. Endocrinologie. (1985) [Pubmed]
  14. The metabolism and motility of human spermatozoa in the presence of steroid hormones and synthetic progestagens. Hyne, R.V., Murdoch, R.N., Boettcher, B. J. Reprod. Fertil. (1978) [Pubmed]
  15. Teratogenicity and embryotoxicity of orally administered lynestrenol in rabbits. Sannes, E., Lyngset, A., Nafstad, I. Arch. Toxicol. (1983) [Pubmed]
  16. Ovarian morphology during and after lynestrenol treatment around menopause. De Baene, L., Van Bogaert, L.J., De Muylder, E., Thomas, K. Contraception. (1982) [Pubmed]
  17. Antiandrogen treatment with spironolactone and linestrenol decreases bone mineral density in eumenorrhoeic women with androgen excess. Prezelj, J., Kocijancic, A. Horm. Metab. Res. (1994) [Pubmed]
  18. Metabolism of levonorgestrel, norethindrone, and structurally related contraceptive steroids. Stanczyk, F.Z., Roy, S. Contraception. (1990) [Pubmed]
  19. Origin of peritoneal fluid in women: an ovarian exudation product. Koninckx, P.R., Renaer, M., Brosens, I.A. British journal of obstetrics and gynaecology. (1980) [Pubmed]
  20. Stimulating properties of lynestrenol on normal human blood T-lymphocytes and other leucocytes. Wybran, J., Govaerts, A., Van Dam, D., Appelboom, T. Int. J. Immunopharmacol. (1979) [Pubmed]
  21. 'Patient failure' as a reliability model for the 'minipill': a clinical study. Nummi, S. Current medical research and opinion. (1978) [Pubmed]
  22. Lynestrenol, an amplifier of lymphocyte stimulation. Wybran, J., Van Bogaert, E., Govaerts, A. Biomedicine / [publiée pour l'A.A.I.C.I.G.]. (1977) [Pubmed]
  23. Binding of steroids to human spermatozoa and its possible role in contraception. Hyne, R.V., Boettcher, B. Fertil. Steril. (1978) [Pubmed]
  24. The effect of various dosages of lynestrenol on the plasma levels of oestrogens and progesterone during the menstrual cycle in the rhesus monkey. Bosu, W.T., Edqvist, L.E., Lindberg, P., Martinsson, K., Johansson, E.D. Contraception. (1976) [Pubmed]
  25. Androgenic, anabolic, estrogenic and antiestrogenic effects of desogestrel and lynestrenol: effects on serum proteins and vaginal cytology. Cullberg, G. Contraception. (1984) [Pubmed]
  26. Effect of long-term hormonal contraception on plasma lipids. Deslypere, J.P., Thiery, M., Vermeulen, A. Contraception. (1985) [Pubmed]
  27. Lynestrenol induced therapeutic amenorrhea: effects of dose reduction on serum sex-hormones and lipids. Huovinen, K.J., Lähteenmäki, P., Kärkkäinen, J., Tikkanen, M.J. Acta obstetricia et gynecologica Scandinavica. (1992) [Pubmed]
  28. Effects on sex hormone binding globulin of different oral contraceptives containing norethisterone and lynestrenol. Odlind, V., Weiner, E., Victor, A., Johansson, E.D. British journal of obstetrics and gynaecology. (1980) [Pubmed]
  29. Immunoenzymatic localization of prolactin-like immunoreactivity in decidual cells of the endometrium from pregnant and nonpregnant women. Meuris, S., Soumenkoff, G., Malengreau, A., Robyn, C. J. Histochem. Cytochem. (1980) [Pubmed]
  30. Acute abdomen due to endometriosis as a diagnostic and therapeutic challenge in the treatment of acute myelocytic leukemia. Karthaus, M., Prahst, A., Geissler, R.G., Hertenstein, B., Degenhardt, F., Ganser, A. Ann. Hematol. (1997) [Pubmed]
  31. Combined (hormonal and microsurgical) therapy in infertile women with endometriosis. Donnez, J., Lemaire-Rubbers, M., Karaman, Y., Nisolle-Pochet, M., Casanas-Roux, F. Fertil. Steril. (1987) [Pubmed]
  32. Treatment of pulmonary endometriosis with danazol. Rönnberg, L., Ylöstalo, P. Acta obstetricia et gynecologica Scandinavica. (1981) [Pubmed]
  33. Long-term progestogen treatment and bone remodelling in peri-menopausal women: a longitudinal study. Dequeker, J., De Muylder, E. Maturitas. (1982) [Pubmed]
  34. Peroral lynestrenol and arterial disease in mentally retarded women. A case-control study based on autopsy findings. Huovinen, K., Autio, S., Kaprio, J. Acta obstetricia et gynecologica Scandinavica. (1988) [Pubmed]
  35. Effects of a progestogen-only pill (Exluton) and an intrauterine device (Multiload Cu250) on breastfeeding. Sinchai, W., Sethavanich, S., Asavapiriyanont, S., Sittipiyasakul, V., Sirikanchanakul, R., Udomkiatsakul, P., Chantaeyoon, P., Roybang, K., Trakankamol, J., Suti, S. Advances in contraception : the official journal of the Society for the Advancement of Contraception. (1995) [Pubmed]
 
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