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Chemical Compound Review

CENTCHROMAN     1-[2-[4-[(3R,4R)-7-methoxy- 2,2-dimethyl-3...

Synonyms: Centron, Saheli, Centchroman-l, Choice 7, Compound 67-20, ...
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Disease relevance of CENTCHROMAN


High impact information on CENTCHROMAN


Chemical compound and disease context of CENTCHROMAN


Biological context of CENTCHROMAN


Anatomical context of CENTCHROMAN

  • Additional experiments were conducted to determine the levels of MMP2 activity in uterus explants from ovariectomized rats following 2 wk of treatment with E, Ral, or one of two additional SERMs: lasofoxifene, and levormeloxifene [6].
  • Excretion of centchroman in breast milk [13].
  • Recovery of normal blastocysts from rats treated continuously with this dose of centchroman at these intervals suggests lack of significant effect on follicular maturation, ovulation, fertilization, preimplantation development or mating behaviour.(ABSTRACT TRUNCATED AT 250 WORDS)[14]
  • A single oral administration of centchroman (1.25 mg/kg) to adult female rats within 24 h of mating induced slight acceleration in the rate of transport of embryos through the oviducts [15].
  • The mean residence time of centchroman was highest in the liver (78.4 hr), followed by the uterus (72.7 hr), adipose tissue (47.5 hr), lung (46 hr), spleen (44.1 hr), and plasma (37.7 hr) [11].

Associations of CENTCHROMAN with other chemical compounds


Gene context of CENTCHROMAN


Analytical, diagnostic and therapeutic context of CENTCHROMAN


  1. Efficacy of levormeloxifene in the prevention of postmenopausal bone loss and on the lipid profile compared to low dose hormone replacement therapy. Alexandersen, P., Riis, B.J., Stakkestad, J.A., Delmas, P.D., Christiansen, C. J. Clin. Endocrinol. Metab. (2001) [Pubmed]
  2. Centchroman--a non-steroidal anti-cancer agent for advanced breast cancer: phase-II study. Misra, N.C., Nigam, P.K., Gupta, R., Agarwal, A.K., Kamboj, V.P. Int. J. Cancer (1989) [Pubmed]
  3. Levormeloxifene: safety, pharmacodynamics and pharmacokinetics in healthy postmenopausal women following single and multiple doses of a new selective oestrogen receptor modulator. Skrumsager, B.K., Kiehr, B., Pedersen, P.C., Gerrits, M., Watson, N., Bjarnason, K. British journal of clinical pharmacology. (2002) [Pubmed]
  4. Adverse effects of a SERM (Levormeloxifene). Safety parameters and bone mineral density 12 months after treatment withdrawal. Warming, L., Christoffersen, C., Riis, B.J., Stakkestad, J.A., Delmas, P.D., Christiansen, C. Maturitas. (2003) [Pubmed]
  5. Centchroman, a selective estrogen receptor modulator, as a contraceptive and for the management of hormone-related clinical disorders. Singh, M.M. Medicinal research reviews. (2001) [Pubmed]
  6. Differential effects of estrogen and raloxifene on messenger RNA and matrix metalloproteinase 2 activity in the rat uterus. Helvering, L.M., Adrian, M.D., Geiser, A.G., Estrem, S.T., Wei, T., Huang, S., Chen, P., Dow, E.R., Calley, J.N., Dodge, J.A., Grese, T.A., Jones, S.A., Halladay, D.L., Miles, R.R., Onyia, J.E., Ma, Y.L., Sato, M., Bryant, H.U. Biol. Reprod. (2005) [Pubmed]
  7. Levormeloxifene prevents increased bone turnover and vertebral bone loss following ovariectomy in cynomolgus monkeys. Hotchkiss, C.E., Stavisky, R., Nowak, J., Brommage, R., Lees, C.J., Kaplan, J. Bone (2001) [Pubmed]
  8. Urogenital effects of selective estrogen receptor modulators: a systematic review. Albertazzi, P., Sharma, S. Climacteric : the journal of the International Menopause Society. (2005) [Pubmed]
  9. Effect of centchroman on preimplantation embryonic development and tubal transport in mice. Singh, M.M., Kamboj, V.P. Biol. Reprod. (1981) [Pubmed]
  10. Induction of ovulation in the human with centchroman: a preliminary report. Roy, S., Kumari, G.L., Madoiya, K., Prakash, V., Ray, S. Fertil. Steril. (1976) [Pubmed]
  11. Tissue distribution and pharmacokinetics of centchroman. A new nonsteroidal postcoital contraceptive agent and its 7-desmethyl metabolite in female rats after a single oral dose. Paliwal, J.K., Gupta, R.C. Drug Metab. Dispos. (1996) [Pubmed]
  12. Cis isomer of centchroman--a selective ligand for the microsomal antiestrogen binding site. Saeed, A., Durani, N., Durani, S., Ray, S., Kapil, R.S. Biochem. Biophys. Res. Commun. (1984) [Pubmed]
  13. Excretion of centchroman in breast milk. Paliwal, J.K., Grover, P.K., Asthana, O.P., Nityanand, S., Gupta, R.C. British journal of clinical pharmacology. (1994) [Pubmed]
  14. Duration of anti-implantation action of the triphenylethylene anti-oestrogen centchroman in adult female rats. Singh, M.M., Sreenivasulu, S., Kamboj, V.P. J. Reprod. Fertil. (1994) [Pubmed]
  15. Effect of centchroman on tubal transport and preimplantation embryonic development in rats. Singh, M.M., Bhalla, V., Wadhwa, V., Kamboj, V.P. J. Reprod. Fertil. (1986) [Pubmed]
  16. Preparation and characterization of sodium hexameta phosphate cross-linked chitosan microspheres for controlled and sustained delivery of centchroman. Gupta, K.C., Jabrail, F.H. Int. J. Biol. Macromol. (2006) [Pubmed]
  17. Determination of estrogenic/antiestrogenic potential of antifertility substances using rat uterine peroxidase assay. Johri, R.K., Pahwa, G.S., Sharma, S.C., Zutshi, U. Contraception. (1991) [Pubmed]
  18. Effect of long-term centchroman treatment on plasma steroid and peptide hormones in female rhesus monkeys (Macaca mulatta). Nigam, P.K., Malaviya, B., Chowdhury, S.R., Kamboj, V.P., Chandra, H. Contraception. (1985) [Pubmed]
  19. Phenotypical response in different cell types of rat uterus to centchroman. A qualitative analysis. Mehrotra, P.K., Srivastava, S. Contraception. (1998) [Pubmed]
  20. Failure of Centchroman to counteract progesterone-induced changes in the uterus of delayed implantation rats. Roy, S., Datta, J.K. Indian J. Exp. Biol. (1977) [Pubmed]
  21. Metabolism, disposition, excretion, and pharmacokinetics of levormeloxifene, a selective estrogen receptor modulator, in the rat. Mountfield, R.J., Kiehr, B., John, B.A. Drug Metab. Dispos. (2000) [Pubmed]
  22. Effect of Centchroman on serum gonadotropins & prolactin in rats. Sheth, A.R., Vaidya, R.A., Arbatti, N.J., Devi, P.K. Indian J. Exp. Biol. (1977) [Pubmed]
  23. Binding of centchroman--a nonsteroidal antifertility agent to human plasma proteins. Srivastava, A.K., Agnihotri, A., Kamboj, V.P. Experientia (1984) [Pubmed]
  24. Evaluation of anti-tumor efficacy of injectable Centchroman in mice bearing Ehrlich ascites carcinoma. Shenoy, B.D., Udupa, N., Kamath, R., Devi, P.U. Indian J. Physiol. Pharmacol. (1999) [Pubmed]
  25. High performance liquid chromatographic (HPLC) determination of centchroman in human serum and application to single-dose pharmacokinetics. Paliwal, J.K., Gupta, R.C., Grover, P.K., Asthana, O.P., Srivastava, J.S., NityaNand, S. Pharm. Res. (1989) [Pubmed]
  26. Value of the micropig model of menopause in the assessment of benefits and risks of postmenopausal therapies for cardiovascular and reproductive tissues. Goodrich, J.A., Clarkson, T.B., Cline, J.M., Jenkins, A.J., Del Signore, M.J. Fertil. Steril. (2003) [Pubmed]
  27. Glutaraldehyde and glyoxal cross-linked chitosan microspheres for controlled delivery of centchroman. Gupta, K.C., Jabrail, F.H. Carbohydr. Res. (2006) [Pubmed]
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