Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

Convicine 6-amino-5-[(2S,3R,4S,5S,6R)- 3,4,5...

Synonyms: SureCN4630048, AC1L3ETZ, AC1Q6LTN, AR-1H0901, C08430, ...

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Disease relevance of C08430

Active principles which are responsible for the haemolysis ( Vicine and Convicine ) were isolated from broad beans and their effects on GSH levels of blood were 99% and 81%, respectively, in favism sensitive subjects and 33.3% and 19% in normal subjects [1].
Effect of neomycin on the hydrolysis and toxicity of vicine and convicine in rats [2].
Vicine and convicine concentrations are reduced by growth of Lactobacillus plantarum on fababean suspensions [3].

High impact information on C08430

Divicine and isouramil are produced on hydrolysis of the fava bean glycosides, vicine and convicine [4].
CAPs markers to assist selection for low vicine and convicine contents in faba bean (Vicia faba L.) [5].

Chemical compound and disease context of C08430

Vicine and convicine in common vetch (Vicia sativa) seeds enhance beta-cyanoalanine toxicity in male broiler chicks [6].

Analytical, diagnostic and therapeutic context of C08430

Changes in the concentrations of vicine, convicine and L-DOPA in two cultivars of Vicia faba L. seeds in different stages of pod development were determined by high performance liquid chromatography (HPLC) [7].

References

Biological activities of broad bean (Vicia faba L.) extracts cultivated in South Anatolia in favism sensitive subjects. Vural, N., Sardas, S. Toxicology (1984) [Pubmed]
Effect of neomycin on the hydrolysis and toxicity of vicine and convicine in rats. Arbid, M.S., Madhyastha, M.S., Marquardt, R.R., Frohlich, A.A. Food Chem. Toxicol. (1993) [Pubmed]
Hydrolysis of vicine and convicine from fababeans by microbial beta-glucosidase enzymes. McKay, A.M. J. Appl. Bacteriol. (1992) [Pubmed]
Auto-oxidation of dialuric acid, divicine and isouramil. Superoxide dependent and independent mechanisms. Winterbourn, C.C., Cowden, W.B., Sutton, H.C. Biochem. Pharmacol. (1989) [Pubmed]
CAPs markers to assist selection for low vicine and convicine contents in faba bean (Vicia faba L.). Gutierrez, N., Avila, C.M., Duc, G., Marget, P., Suso, M.J., Moreno, M.T., Torres, A.M. Theor. Appl. Genet. (2006) [Pubmed]
Vicine and convicine in common vetch (Vicia sativa) seeds enhance beta-cyanoalanine toxicity in male broiler chicks. Farran, M.T., Darwish, A.H., Uwayjan, M.G., Sleiman, F.T., Ashkarian, V.M. International journal of toxicology. (2002) [Pubmed]
Variation of favism-inducing factors (vicine, convicine and L-DOPA) during pod development in Vicia faba L. Burbano, C., Cuadrado, C., Muzquiz, M., Cubero, J.I. Plant foods for human nutrition (Dordrecht, Netherlands) (1995) [Pubmed]

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