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Chemical Compound Review

Vicine     2,6-diamino-5- [(2S,3R,4S,5R,6R)-3,4,5...

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Disease relevance of Vicine

  • Although untreated vetch used in this study contained 32% less BCA but 8% and 81% more vicine and convicine, respectively, yet, the chicks on 60% untreated vetch showed toxicity symptoms earlier than those of study 1 [1].

High impact information on Vicine


Associations of Vicine with other chemical compounds

  • The procedure involves differential extraction of the glucosides vicine and convicine with acetic acid (25%), followed by an enzymatic hydrolysis by beta-glucosidase under anaerobic conditions [7].
  • Upon hydrolysis of the inactive beta-glucoside vicine, reduced divicine is formed [8].
  • 1. Experiments were conducted to study the effects of dietary vicine (2, 6-diamino-4, 5 dihydroxy pyrimidine-5 (beta-D-glucopyranoside)) and supplemental vitamin E on the performance of laying hens and growing chicks, haemolysis of erythrocytes than birds fed on a control diet [9].

Gene context of Vicine


  1. Vicine and convicine in common vetch (Vicia sativa) seeds enhance beta-cyanoalanine toxicity in male broiler chicks. Farran, M.T., Darwish, A.H., Uwayjan, M.G., Sleiman, F.T., Ashkarian, V.M. International journal of toxicology. (2002) [Pubmed]
  2. Exolytic hydrolysis of toxic plant glucosides by guinea pig liver cytosolic beta-glucosidase. Gopalan, V., Pastuszyn, A., Galey, W.R., Glew, R.H. J. Biol. Chem. (1992) [Pubmed]
  3. Chemical analysis and hemolytic activity of the fava bean aglycon divicine. McMillan, D.C., Schey, K.L., Meier, G.P., Jollow, D.J. Chem. Res. Toxicol. (1993) [Pubmed]
  4. Auto-oxidation of dialuric acid, divicine and isouramil. Superoxide dependent and independent mechanisms. Winterbourn, C.C., Cowden, W.B., Sutton, H.C. Biochem. Pharmacol. (1989) [Pubmed]
  5. CAPs markers to assist selection for low vicine and convicine contents in faba bean (Vicia faba L.). Gutierrez, N., Avila, C.M., Duc, G., Marget, P., Suso, M.J., Moreno, M.T., Torres, A.M. Theor. Appl. Genet. (2006) [Pubmed]
  6. Iron release and oxidant damage in human myoblasts by divicine. Ninfali, P., Perini, M.P., Bresolin, N., Aluigi, G., Cambiaggi, C., Ferrali, M., Pompella, A. Life Sci. (2000) [Pubmed]
  7. A novel method for quantitation of favism-inducing agents in legumes. Chevion, M., Navok, T. Anal. Biochem. (1983) [Pubmed]
  8. Mechanism of action of divicine in a cell-free system and in glucose-6-phosphate dehydrogenase-deficient red cells. Baker, M.A., Bosia, A., Pescarmona, G., Turrini, F., Arese, P. Toxicologic pathology. (1984) [Pubmed]
  9. Effect of dietary vicine and vitamin E supplementation on the productive performance of growing and laying chickens. Muduuli, D.S., Marquardt, R.R., Guenter, W. Br. J. Nutr. (1982) [Pubmed]
  10. Hydrolysis of vicine and convicine from fababeans by microbial beta-glucosidase enzymes. McKay, A.M. J. Appl. Bacteriol. (1992) [Pubmed]
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