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MeSH Review

Vicia faba

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Disease relevance of Vicia faba


High impact information on Vicia faba

  • To analyze sugar transport processes during seed development of fava bean, we cloned cDNAs encoding one sucrose and one hexose transporter, designated VfSUT1 and VfSTP1, respectively. sugar uptake activity was confirmed after heterologous expression in yeast [5].
  • A role for sugar transporters during seed development: molecular characterization of a hexose and a sucrose carrier in fava bean seeds [5].
  • CO(2)-triggered chloride release from guard cells in intact fava bean leaves. Kinetics of the onset of stomatal closure [6].
  • The interaction between one particular rhizobial symbiotic genotype and fava bean seems to be highly specific for nodulation and linked to the efficiency of nitrogen fixation [7].
  • Rats consuming lupin or faba bean globulins excreted significantly more nitrogen, particularly as urea through the urine [8].

Biological context of Vicia faba


Anatomical context of Vicia faba


Associations of Vicia faba with chemical compounds


Gene context of Vicia faba

  • The results are consistent with a causal role of divicine/isouramil in the genesis of the hemolytic crisis occurring in G6PD-deficient subjects after fava bean ingestion [17].
  • Concanavalin A (Con A) and agglutinins from the pea (PSA), lentil (LCH), and fava bean (VFA) constitute a group of D-mannose/D-glucose binding legume lectins [18].
  • In the present study, plasma lipid concentrations were determined at different times after admission in sera from G6PD-deficient children during haemolytic crisis induced by fava bean ingestion [19].
  • The incidence of the haemolytic episodes was found to peak in April, while the fava bean season extends from February to June [20].
  • Normal levels of antioxidant enzymes were found in all subjects examined both with positive and negative histories of haemolytic crisis after fava bean or drug ingestion [21].

Analytical, diagnostic and therapeutic context of Vicia faba


  1. Increased red cell calcium, decreased calcium adenosine triphosphatase, and altered membrane proteins during fava bean hemolysis in glucose-6-phosphate dehydrogenase-deficient (Mediterranean variant) individuals. Turrini, F., Naitana, A., Mannuzzu, L., Pescarmona, G., Arese, P. Blood (1985) [Pubmed]
  2. Sequences of ten circular ssDNA components associated with the milk vetch dwarf virus genome. Sano, Y., Wada, M., Hashimoto, Y., Matsumoto, T., Kojima, M. J. Gen. Virol. (1998) [Pubmed]
  3. Favism: effect of divicine on rat erythrocyte sulfhydryl status, hexose monophosphate shunt activity, morphology, and membrane skeletal proteins. McMillan, D.C., Bolchoz, L.J., Jollow, D.J. Toxicol. Sci. (2001) [Pubmed]
  4. Favism: divicine hemotoxicity in the rat. McMillan, D.C., Jollow, D.J. Toxicol. Sci. (1999) [Pubmed]
  5. A role for sugar transporters during seed development: molecular characterization of a hexose and a sucrose carrier in fava bean seeds. Weber, H., Borisjuk, L., Heim, U., Sauer, N., Wobus, U. Plant Cell (1997) [Pubmed]
  6. CO(2)-triggered chloride release from guard cells in intact fava bean leaves. Kinetics of the onset of stomatal closure. Hanstein, S.M., Felle, H.H. Plant Physiol. (2002) [Pubmed]
  7. Compatibility of rhizobial genotypes within natural populations of Rhizobium leguminosarum biovar viciae for nodulation of host legumes. Laguerre, G., Louvrier, P., Allard, M.R., Amarger, N. Appl. Environ. Microbiol. (2003) [Pubmed]
  8. The utilization of lupin (Lupinus angustifolius) and faba bean globulins by rats is poorer than of soybean globulins or lactalbumin but the nutritional value of lupin seed meal is lower only than that of lactalbumin. Rubio, L.A., Grant, G., Scislowski, P.W., Brown, D., Bardocz, S., Pusztai, A. J. Nutr. (1995) [Pubmed]
  9. Auto-oxidation of dialuric acid, divicine and isouramil. Superoxide dependent and independent mechanisms. Winterbourn, C.C., Cowden, W.B., Sutton, H.C. Biochem. Pharmacol. (1989) [Pubmed]
  10. Neonatal nucleated red blood cells in G6PD deficiency. Yeruchimovich, M., Shapira, B., Mimouni, F.B., Dollberg, S. American journal of perinatology. (2002) [Pubmed]
  11. Inhibitory effect of a fava bean component on the in vitro development of Plasmodium falciparum in normal and glucose-6-phosphate dehydrogenase deficient erythrocytes. Golenser, J., Miller, J., Spira, D.T., Navok, T., Chevion, M. Blood (1983) [Pubmed]
  12. Lymphocyte changes in favism: in vitro evidence of a modifying effect of bilirubin and hemoglobin on T-lymphocyte receptors. Schilirò, G., Sciotto, A., Russo, A., Bottaro, G., Minniti, C., Musumeci, S., Russo, G. Acta Haematol. (1983) [Pubmed]
  13. Chemical analysis and hemolytic activity of the fava bean aglycon divicine. McMillan, D.C., Schey, K.L., Meier, G.P., Jollow, D.J. Chem. Res. Toxicol. (1993) [Pubmed]
  14. Resistance of glucose-6-phosphate dehydrogenase deficiency to malaria: effects of fava bean hydroxypyrimidine glucosides on Plasmodium falciparum growth in culture and on the phagocytosis of infected cells. Ginsburg, H., Atamna, H., Shalmiev, G., Kanaani, J., Krugliak, M. Parasitology (1996) [Pubmed]
  15. New fava bean guard cell signaling mutant impaired in ABA-induced stomatal closure. Iwai, S., Shimomura, N., Nakashima, A., Etoh, T. Plant Cell Physiol. (2003) [Pubmed]
  16. Purification and characterization of a phytate-degrading enzyme from germinated faba beans (Vicia faba Var. Alameda). Greiner, R., Muzquiz, M., Burbano, C., Cuadrado, C., Pedrosa, M.M., Goyoaga, C. J. Agric. Food Chem. (2001) [Pubmed]
  17. Effect of divicine and isouramil on red cell metabolism in normal and G6PD-deficient (Mediterranean variant) subjects. Possible role in the genesis of favism. Arese, P., Bosia, A., Naitana, A., Gaetani, S., D'Aquino, M., Gaetani, G.F. Prog. Clin. Biol. Res. (1981) [Pubmed]
  18. Synthesis of high-affinity, hydrophobic monosaccharide derivatives and study of their interaction with concanavalin A, the pea, the lentil, and fava bean lectins. Loganathan, D., Osborne, S.E., Glick, G.D., Goldstein, I.J. Arch. Biochem. Biophys. (1992) [Pubmed]
  19. Serum lipoprotein pattern as modified in G6PD-deficient children during haemolytic anaemia induced by fava bean ingestion. Dessì, S., Batetta, B., Spano, O., Pulisci, D., Mulas, M.F., Muntoni, S., Armeni, M., Sanna, C., Antonucci, R., Pani, P. International journal of experimental pathology. (1992) [Pubmed]
  20. Acute haemolytic episodes & fava bean consumption in G6PD deficient Iraqis. Yahya, H.I., al-Allawi, N.A. Indian J. Med. Res. (1993) [Pubmed]
  21. Erythrocyte superoxide dismutase, catalase and glutathione peroxidase in glucose-6-phosphate dehydrogenase deficiency. Gerli, G.C., Beretta, L., Bianchi, M., Agostoni, A., Gualandri, V., Orsini, G.B. Scandinavian journal of haematology. (1982) [Pubmed]
  22. Studies on estrogenic effects of faba bean (Vicia faba L. minor) products using the mouse uterine bioassay. Plass, R., Schneider, C., Lewerenz, H.J., Schmandke, H. Die Nahrung. (1990) [Pubmed]
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