Disease relevance of Vicia faba

• Increased red cell calcium, decreased calcium adenosine triphosphatase, and altered membrane proteins during fava bean hemolysis in glucose-6-phosphate dehydrogenase-deficient (Mediterranean variant) individuals [1].
• Comparison of the sequences with those of other nanoviruses reveals that MDV is closely related to faba bean necrotic yellows virus (FBNYV) and subterranean clover stunt virus (SCSV) [2].
• The fava bean pyrimidine aglycone divicine has been identified as a hemotoxic constituent; however, its mechanism of toxicity remains unknown [3].
• Although the fava bean pyrimidine aglycones, divicine and isouramil, have been implicated in the onset of favism in humans, the lack of a well-defined experimental animal model for favism has hampered progress in elucidating the mechanism underlying hemotoxicity [4].

High impact information on Vicia faba

• To analyze sugar transport processes during seed development of fava bean, we cloned cDNAs encoding one sucrose and one hexose transporter, designated VfSUT1 and VfSTP1, respectively. sugar uptake activity was confirmed after heterologous expression in yeast [5].
• A role for sugar transporters during seed development: molecular characterization of a hexose and a sucrose carrier in fava bean seeds [5].
• CO(2)-triggered chloride release from guard cells in intact fava bean leaves. Kinetics of the onset of stomatal closure [6].
• The interaction between one particular rhizobial symbiotic genotype and fava bean seems to be highly specific for nodulation and linked to the efficiency of nitrogen fixation [7].
• Rats consuming lupin or faba bean globulins excreted significantly more nitrogen, particularly as urea through the urine [8].

Biological context of Vicia faba

• Divicine and isouramil are produced on hydrolysis of the fava bean glycosides, vicine and convicine [9].
• We tested the hypothesis that hematocrit and hemoglobin would be lower, and absolute nucleated RBC counts higher, in the G6PD deficient and that these changes would be more prominent in infants exposed passively to fava bean through maternal diet [10].

Anatomical context of Vicia faba

• Inhibitory effect of a fava bean component on the in vitro development of Plasmodium falciparum in normal and glucose-6-phosphate dehydrogenase deficient erythrocytes [11].
• Lymphocyte subpopulations were studied in 13 Sicilian glucose-6-phosphate dehydrogenase (G6PD)-deficient children during and after the hemolytic crisis due to fava bean ingestion [12].

Associations of Vicia faba with chemical compounds

• Chemical analysis and hemolytic activity of the fava bean aglycon divicine [13].
• Divicine is an unstable aglycon metabolite of the fava bean pyrimidine beta-glucoside vicine [13].
• The implicated fava bean constituents are the hydroxypyrimidine glucosides vicine and convicine, which upon hydrolysis of their beta-O-glucosidic bond, became protein pro-oxidants [14].
• The mutant is named fia (fava bean impaired in ABA-induced stomatal closure) [15].
• 0. The faba bean phytase exhibits a broad affinity for various phosphorylated compounds and hydrolyzes phytate in a stepwise manner [16].

Gene context of Vicia faba

• The results are consistent with a causal role of divicine/isouramil in the genesis of the hemolytic crisis occurring in G6PD-deficient subjects after fava bean ingestion [17].
• Concanavalin A (Con A) and agglutinins from the pea (PSA), lentil (LCH), and fava bean (VFA) constitute a group of D-mannose/D-glucose binding legume lectins [18].
• In the present study, plasma lipid concentrations were determined at different times after admission in sera from G6PD-deficient children during haemolytic crisis induced by fava bean ingestion [19].
• The incidence of the haemolytic episodes was found to peak in April, while the fava bean season extends from February to June [20].
• Normal levels of antioxidant enzymes were found in all subjects examined both with positive and negative histories of haemolytic crisis after fava bean or drug ingestion [21].

Analytical, diagnostic and therapeutic context of Vicia faba

• Studies on estrogenic effects of faba bean (Vicia faba L. minor) products using the mouse uterine bioassay [22].

References