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Chemical Compound Review

Isouramil     6-amino-5-hydroxy-1H- pyrimidine-2,4-dione

Synonyms: AG-K-61522, SureCN2236804, SureCN3167524, SureCN3167526, SureCN4294778, ...
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Disease relevance of Isouramil


High impact information on Isouramil


Biological context of Isouramil


Associations of Isouramil with other chemical compounds


Gene context of Isouramil

  • Effect of divicine and isouramil on red cell metabolism in normal and G6PD-deficient (Mediterranean variant) subjects. Possible role in the genesis of favism [8].


  1. Protection against oxidative damage of erythrocyte membrane by the flavonoid quercetin and its relation to iron chelating activity. Ferrali, M., Signorini, C., Caciotti, B., Sugherini, L., Ciccoli, L., Giachetti, D., Comporti, M. FEBS Lett. (1997) [Pubmed]
  2. Reproductive performance of hens fed field beans and potential relationships to vicine metabolism. Naber, E.C., Vogt, H., Harnish, S., Krieg, R., Ueberschaer, K.H., Rauch, H.W. Poult. Sci. (1988) [Pubmed]
  3. Favism: impairment of proteolytic systems in red blood cells. Morelli, A., Grasso, M., Meloni, T., Forteleoni, G., Zocchi, E., De Flora, A. Blood (1987) [Pubmed]
  4. Iron ion-dependent modification of bases in DNA by the superoxide radical-generating system hypoxanthine/xanthine oxidase. Aruoma, O.I., Halliwell, B., Dizdaroglu, M. J. Biol. Chem. (1989) [Pubmed]
  5. Ferritin, lipid peroxidation and redox-cycling xenobiotics. Winterbourn, C.C., Vile, G.F., Monteiro, H.P. Free Radic. Res. Commun. (1991) [Pubmed]
  6. Pathophysiology of favism. Arese, P., Mannuzzu, L., Turrini, F. Folia Haematol. Int. Mag. Klin. Morphol. Blutforsch. (1989) [Pubmed]
  7. Inhibition of the intraerythrocytic development of Plasmodium falciparum in glucose-6-phosphate dehydrogenase deficient erythrocytes is enhanced by oxidants and by crisis form factor. Golenser, J., Miller, J., Spira, D.T., Kosower, N.S., Vande Waa, J.A., Jensen, J.B. Trop. Med. Parasitol. (1988) [Pubmed]
  8. Effect of divicine and isouramil on red cell metabolism in normal and G6PD-deficient (Mediterranean variant) subjects. Possible role in the genesis of favism. Arese, P., Bosia, A., Naitana, A., Gaetani, S., D'Aquino, M., Gaetani, G.F. Prog. Clin. Biol. Res. (1981) [Pubmed]
  9. Iron release and membrane damage in erythrocytes exposed to oxidizing agents, phenylhydrazine, divicine and isouramil. Ferrali, M., Signorini, C., Ciccoli, L., Comporti, M. Biochem. J. (1992) [Pubmed]
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