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Chemical Compound Review

INDAZOLE     1H-indazole

Synonyms: BENZPYRAZOL, ISOINDAZONE, Isoindazole, BENZPYRAZOLE, Benzopyrazole, ...
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High impact information on Isoindazole


Associations of Isoindazole with other chemical compounds


Gene context of Isoindazole

  • Within this series, use of the 1H-indazole ring as an aromatic moiety led to a substantial increase of the activity; the 1H-indazolylcarboxamides 54, 57, 97, and 102 showed potent 5-HT3 receptor antagonistic activity [4].


  1. Synthesis of 2H-indazoles via Lewis acid promoted cyclization of 2-(phenylazo)benzonitriles. Shirtcliff, L.D., Rivers, J., Haley, M.M. J. Org. Chem. (2006) [Pubmed]
  2. Design and synthesis of Rho kinase inhibitors (II). Iwakubo, M., Takami, A., Okada, Y., Kawata, T., Tagami, Y., Ohashi, H., Sato, M., Sugiyama, T., Fukushima, K., Iijima, H. Bioorg. Med. Chem. (2007) [Pubmed]
  3. Design and synthesis of Rho kinase inhibitors (I). Takami, A., Iwakubo, M., Okada, Y., Kawata, T., Odai, H., Takahashi, N., Shindo, K., Kimura, K., Tagami, Y., Miyake, M., Fukushima, K., Inagaki, M., Amano, M., Kaibuchi, K., Iijima, H. Bioorg. Med. Chem. (2004) [Pubmed]
  4. Development of potent serotonin-3 (5-HT3) receptor antagonists. II. Structrue-activity relationships of N-(1-benzyl-4-methylhexahydro-1H-1,4- diazepin-6-yl)carboxamides. Harada, H., Morie, T., Hirokawa, Y., Terauchi, H., Fujiwara, I., Yoshida, N., Kato, S. Chem. Pharm. Bull. (1995) [Pubmed]
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