The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

PA-L-Glutamine     (2S)-4-aminocarbonyl-2-(2...

Synonyms: SureCN236527, AG-E-89667, CHEBI:17884, HMDB06344, ANW-43282, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Phenylacetylglutamine


High impact information on Phenylacetylglutamine


Biological context of Phenylacetylglutamine


Associations of Phenylacetylglutamine with other chemical compounds


Gene context of Phenylacetylglutamine


Analytical, diagnostic and therapeutic context of Phenylacetylglutamine

  • The concentrations of PAA and its inactive metabolite, phenylacetylglutamine (PAG), were measured using a reverse-phase high-performance liquid chromatography assay with ultraviolet detection [10].
  • A reverse phase HPLC method for the quantitative determination of phenylacetylglutamine in plasma ultrafiltrates is described [11].
  • Because over 90% of total urine PAA in humans is conjugated, it is concluded that over 50% of urine phenylacetylglutamine may be derived from kidney conjugation of free plasma PAA and/or from the kidney's preferential filtration of conjugated PAA as contrasted with free PAA [12].


  1. Antiestrogenic piperidinediones designed prospectively using computer graphics and energy calculations of DNA-ligand complexes. Hendry, L.B., Chu, C.K., Copland, J.A., Mahesh, V.B. J. Steroid Biochem. Mol. Biol. (1994) [Pubmed]
  2. Non-invasive tracing of liver intermediary metabolism in normal subjects and in moderately hyperglycaemic NIDDM subjects. Evidence against increased gluconeogenesis and hepatic fatty acid oxidation in NIDDM. Diraison, F., Large, V., Brunengraber, H., Beylot, M. Diabetologia (1998) [Pubmed]
  3. Glutamate, a window on liver intermediary metabolism. Yang, D., Brunengraber, H. J. Nutr. (2000) [Pubmed]
  4. Disposition of phenylbutyrate and its metabolites, phenylacetate and phenylacetylglutamine. Piscitelli, S.C., Thibault, A., Figg, W.D., Tompkins, A., Headlee, D., Lieberman, R., Samid, D., Myers, C.E. Journal of clinical pharmacology. (1995) [Pubmed]
  5. Assay of the concentration and 13C-labeling pattern of phenylacetylglutamine by nuclear magnetic resonance. Dugelay, S., Yang, D., Soloviev, M.V., Previs, S.F., Agarwal, K.C., Fernandez, C.A., Brunengraber, H. Anal. Biochem. (1994) [Pubmed]
  6. Aging: gene silencing or gene activation? Burzynski, S.R. Med. Hypotheses (2005) [Pubmed]
  7. Inhibitory effect of antineoplaston A10 and AS2-1 on human hepatocellular carcinoma. Tsuda, H., Iemura, A., Sata, M., Uchida, M., Yamana, K., Hara, H. The Kurume medical journal. (1996) [Pubmed]
  8. Inhibition of estrogen stimulated mitogenesis by 3-phenylacetylamino-2,6-piperidinedione and its para-hydroxy analog. Copland, J.A., Hendry, L.B., Chu, C.K., Wood, J.C., Wrenn, R.W., Pantazis, C.G., Mahesh, V.B. J. Steroid Biochem. Mol. Biol. (1993) [Pubmed]
  9. Noninvasive probing of citric acid cycle intermediates in primate liver with phenylacetylglutamine. Yang, D., Previs, S.F., Fernandez, C.A., Dugelay, S., Soloviev, M.V., Hazey, J.W., Agarwal, K.C., Levine, W.C., David, F., Rinaldo, P., Beylot, M., Brunengraber, H. Am. J. Physiol. (1996) [Pubmed]
  10. Pharmacokinetics of phenylacetate administered as a 30-min infusion in children with refractory cancer. Thompson, P., Balis, F., Serabe, B.M., Berg, S., Adamson, P., Klenke, R., Aiken, A., Packer, R., Murry, D.J., Jakacki, R., Blaney, S.M. Cancer Chemother. Pharmacol. (2003) [Pubmed]
  11. Identification and determination of phenylacetylglutamine, a major nitrogenous metabolite in plasma of uremic patients. Zimmerman, L., Egestad, B., Jörnvall, H., Bergström, J. Clin. Nephrol. (1989) [Pubmed]
  12. Plasma and cerebrospinal fluid concentration of phenylacetic acid in humans and monkeys. Karoum, F., Chuang, L.W., Mosnaim, A.D., Staub, R.A., Wyatt, R.J. Journal of chromatographic science. (1983) [Pubmed]
WikiGenes - Universities