High impact information on cyclooctane

• In the present paper we expanded SAR studies of 3, the ethyl analogue of the AChE inhibitor caproctamine (2), by investigating the role of its octamethylene spacer separating the two amide functions through the replacement with dipiperidine and dianiline moieties [1].
• Pressure-supported electrochromatography using capillaries packed with permethyl-cyclodextrin covalently linked via an octamethylene spacer to dimethylpolysiloxane and immobilized on silica (Chirasil-Dex silica) has been employed as an efficient and rapid method for the enantiomer separation of various racemic compounds [2].
• In the cytopathogenesis assay, the most active compound is a bis naphthalenedisulfonic acid derivative 17, containing a flexible octamethylene spacer and exhibiting an in vitro therapeutic index of 29 [3].
• With cyclooctane, B3LYP predicts that the boat-chair and crown conformers have similar energies, whereas MP2 and CCSD(T) predict that the crown conformer is 2 kcal/mol higher in energy [4].
• Solubilities are reported for benzil in carbon tetrachloride-alkane (isooctane, n-octane, cyclooctane) systems at 25 degrees and in similar binary mixtures containing cyclohexane plus alkane [5].

Analytical, diagnostic and therapeutic context of cyclooctane

• The self-inclusion behavior and induced circular dichroism (ICD) characteristics of two beta-cyclodextrin (beta-CD) derivatives, in which a 1-methyl-4,4'-bipyridinium (viologen) group is connected by an octamethylene chain to either the primary (2(2+)) or secondary (3(2+)) side of beta-CD, and of their reduced forms, are investigated [6].

References