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Chemical Compound Review

Amidofos     N-[(2-chloro-4-tert-butyl- phenoxy)-methoxy...

Synonyms: Crufomat, Amidophos, Crufomate, Crufomato, Montrel, ...
 
 
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Disease relevance of Crufomate A

  • The dosage rate of crufomate was 17 mg of active drug/kg of body weight daily for 3 consecutive days [1].
  • Each treatment with crufomate caused about 50% reversible inhibition of cholinesterase activity without inducing any signs of toxicity [2].
 

High impact information on Crufomate A

  • Controlled test of the efficacy of the feed premix formulation of crufomate on the parasites of the gastrointestinal tract and lungs of dairy calves [1].
  • Upon comparison of the reactivation of AChE inhibited by methamidophos with that of AChE inhibited by an N-methyl analogue, crufomate, and an N,N-dimethyl analogue, tabun, it appears that the rate of spontaneous reactivation decreases with increasing alkylation of the P-NH2 group [3].
  • In one experiment, the crufomate compound had apparent erratic effects on serum ace5ylcholinesterase activities, but no effects on electrocardiographic patterns, heart rate, or respiration rate [4].
  • Effects on reproduction and litter growth were studied for two successive reproductive periods (RP)--interval between caging females with males and whelping--in female mice treated dermally with crufomate at 100 or 50 mg/kg on days 35 and 21 before caging with untreated males [2].
 

Analytical, diagnostic and therapeutic context of Crufomate A

References

  1. Controlled test of the efficacy of the feed premix formulation of crufomate on the parasites of the gastrointestinal tract and lungs of dairy calves. Lyons, E.T., Tolliver, S.C., Drudge, J.H. Am. J. Vet. Res. (1982) [Pubmed]
  2. Reproduction and growth of progeny of female mice mated after treatment with crufomate. Khan, M.A. Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes. (1981) [Pubmed]
  3. Reactivation of acetylcholinesterase inhibited by methamidophos and analogous (di)methylphosphoramidates. de Jong, L.P., Wolring, G.Z., Benschop, H.P. Arch. Toxicol. (1982) [Pubmed]
  4. Effects of organic phosphate systemic insecticides on bovine embryonic survival and development. Bellows, R.A., Rumsey, T.S., Kasson, C.W., Bond, J., Warwick, E.J., Pahnish, O.F. Am. J. Vet. Res. (1975) [Pubmed]
 
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