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Chemical Compound Review

Diodrast     bis(2-hydroxyethyl)azanium; 2-(3,5-diiodo...

Synonyms: Diatrast, Diodonum, Oparenol, Pelviran, Pyelosil, ...
 
 
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High impact information on Cardiotrast

  • Uptake of radioactivity from a solution containing 500 nmol l(-)(1) [(3)H]cAMP and 9.5 micromol l(-)(1) cAMP was reduced by more than 90 % by 1 mmol l(-)(1) PSP, by approximately 40 % by 0.2 mmol l(-)(1) probenecid, by 36 % by 1 mmol l(-)(1) diodrast and by 30 % by 1 mmol l(-)(1) PAH [1].
  • Tetrodotoxic poisoning from ingestion of a porcupine fish (Diodon hystrix) in Papua New Guinea: nerve conduction studies [2].
  • In the present study, skin secretions from Ciclichthys spinosus, S. spengleri and Diodon hystrix were tested on crustacean nerves, sea urchin eggs and mouse erythrocyte suspensions to verify neurotoxic and cytotoxic activities [3].
  • A physiologically based kidney model is proposed comprising all the functional characteristics of the kidney that determine the excretion of iodopyracet, i.e. renal plasma flow, urine flow, protein binding, glomerular filtration, tubular secretion, and tubular accumulation [4].
  • In a fundamental study on the kinetics of the urinary excretion of a number of agents secreted by the renal tubules of the mammalian kidney, we measured plasma levels of iodopyracet after intravenous application to male beagle dogs [5].

References

  1. Fluid secretion by isolated Malpighian tubules of Drosophila melanogaster Meig.: effects of organic anions, quinacrine and a diuretic factor found in the secreted fluid. Riegel, J.A., Farndale, R.W., Maddrell, S.H. J. Exp. Biol. (1999) [Pubmed]
  2. Tetrodotoxic poisoning from ingestion of a porcupine fish (Diodon hystrix) in Papua New Guinea: nerve conduction studies. Trevett, A.J., Mavo, B., Warrell, D.A. Am. J. Trop. Med. Hyg. (1997) [Pubmed]
  3. Occurrence of toxins, other than paralysing type, in the skin of Tetraodontiformes fish. Malpezzi, E.L., de Freitas, J.C., Rantin, F.T. Toxicon (1997) [Pubmed]
  4. Physiologically based pharmacokinetic model for the renal clearance of iodopyracet and the interaction with probenecid in the dog. Russel, F.G., Wouterse, A.C., Van Ginneken, C.A. Biopharmaceutics & drug disposition. (1989) [Pubmed]
  5. Kinetic modeling of the renal excretion of iodopyracet in the dog. Hekman, P., van Ginneken, C.A. Journal of pharmacokinetics and biopharmaceutics. (1982) [Pubmed]
 
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