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Chemical Compound Review:

Palmitone hentriacontan-16-one

Synonyms: NSC-953, NSC953, ACMC-1AU7I, CHEBI:5658, AG-F-68837, ...

Eva Gonz??lez-Trujano, M. et al., González-Trujano, M.E. et al., González-Trujano, M.E. et al., Ahibo-Coffy, A. et al.

González-Trujano, Martínez, Reyes-Ramírez, Reyes-Trejo, Navarrete,

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Disease relevance of Palmitone

Purpose: To evaluate hypnotic and anticonvulsant activities of Annona diversifolia Saff. and palmitone by using behavior and electroencephalographic (EEG) analysis in an experimental model of focal seizures in rats [1].
The isolation of a 'palmitone lipid' from Corynebacterium diphtheriae is described [2].
Palmitone did not produce motor incoordination and loss of righting reflex which are used as signs of neurological impairment [3].

Psychiatry related information on Palmitone

In addition, both palmitone and extract decreased SWS duration and accumulated REM sleep phase [1].
Methods: For hypnotic assessment, EEG analysis of polysomnographic slow-wave sleep (SWS) and rapid eye movement (REM) sleep for a 1 h period were performed after vehicle, A. diversifolia extract or palmitone, administration [1].
Moreover, palmitone at any dose caused no change in motor activity nor disruption in traction performance [4].

High impact information on Palmitone

Anticonvulsant Effect of Annona diversifolia Saff. and Palmitone on Penicillin-induced Convulsive Activity. A Behavioral and EEG Study in Rats [1].

References

Anticonvulsant Effect of Annona diversifolia Saff. and Palmitone on Penicillin-induced Convulsive Activity. A Behavioral and EEG Study in Rats. Eva Gonz??lez-Trujano, M., Tapia, E., L??pez-Meraz, L., Navarrete, A., Reyes-Ram??rez, A., Mart??nez, A. Epilepsia (2006) [Pubmed]
Isolation, structural studies and chemical synthesis of a 'palmitone lipid' from Corynebacterium diphtheriae. Ahibo-Coffy, A., Aurelle, H., Lacave, C., Prome, J.C., Puzo, G., Savagnac, A. Chem. Phys. Lipids (1978) [Pubmed]
Anticonvulsant properties and bio-guided isolation of palmitone from leaves of Annona diversifolia. González-Trujano, M.E., Navarrete, A., Reyes, B., Cedillo-Portugal, E., Hong, E. Planta Med. (2001) [Pubmed]
Palmitone isolated from Annona diversifolia induces an anxiolytic-like effect in mice. González-Trujano, M.E., Martínez, A.L., Reyes-Ramírez, A., Reyes-Trejo, B., Navarrete, A. Planta Med. (2006) [Pubmed]

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