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Gene Review

INSL5  -  insulin-like 5

Homo sapiens

Synonyms: Insulin-like peptide 5, Insulin-like peptide INSL5, PRO182, UNQ156, UNQ156/PRO182
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High impact information on INSL5


Biological context of INSL5


Anatomical context of INSL5

  • Using quantitative RT-PCR, expression of murine INSL5 was detected in the highest quantity in colon followed by thymus, and minimal expression was seen in testis [2].

Associations of INSL5 with chemical compounds

  • In addition, INSL5 stimulates Ca(2+) mobilization in HEK293 cells expressing GPCR142 and G alpha(16) [1].
  • In functional guanosine (gamma-thio)-triphosphate binding and cAMP accumulation assays, INSL5 potently activates GPCR142 with EC(50) values of 1.3 and 1.2 nM, respectively [1].
  • A new member of the insulin gene superfamily (INSL5) was identified by searching EST databases for the presence of the conserved insulin B-chain cysteine motif [2].

Other interactions of INSL5

  • In this report, we demonstrate that INSL5 is a specific agonist for GPCR142 [1].
  • A functional assay shows that INSL5 (1 microm) is a weak antagonist for GPCR135 [1].

Analytical, diagnostic and therapeutic context of INSL5

  • Northern blot analysis detected expression of human INSL5 in rectal, colon, and uterine tissue and of murine INSL5 only in thymic tissue [2].


  1. INSL5 is a high affinity specific agonist for GPCR142 (GPR100). Liu, C., Kuei, C., Sutton, S., Chen, J., Bonaventure, P., Wu, J., Nepomuceno, D., Kamme, F., Tran, D.T., Zhu, J., Wilkinson, T., Bathgate, R., Eriste, E., Sillard, R., Lovenberg, T.W. J. Biol. Chem. (2005) [Pubmed]
  2. Identification of INSL5, a new member of the insulin superfamily. Conklin, D., Lofton-Day, C.E., Haldeman, B.A., Ching, A., Whitmore, T.E., Lok, S., Jaspers, S. Genomics (1999) [Pubmed]
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