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Gene Review

TSPAN32  -  tetraspanin 32

Homo sapiens

Synonyms: ART1, PHEMX, PHMX, Protein Phemx, TSSC6, ...
 
 
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High impact information on TSPAN32

  • Phemx maps to the distal region of chromosome 7, a segment of the mouse genome that contains a cluster of genes that exhibit genomic imprinting [1].
  • The human PHEMX ortholog is specifically expressed in hematopoietic organs and tissues and, in contrast to murine Phemx, undergoes alternative splicing [1].
  • Conceptual translation of the murine Phemx cDNA predicts a 25-kDa polypeptide with four hydrophobic regions and several potential phosphorylation sites, suggestive of a transmembrane protein involved in cell signaling [1].
  • Phemx (Pan hematopoietic expression) is a novel murine gene expressed in developmentally regulated sites of hematopoiesis from early in embryogenesis through adulthood [1].
  • Using 5'-RACE and cDNA library screening, we identified an additional 5' sequence for both the murine Tssc6 cDNA and its human homologue TSSC6 [2].

References

  1. Phemx, a novel mouse gene expressed in hematopoietic cells maps to the imprinted cluster on distal chromosome 7. Nicholson, R.H., Pantano, S., Eliason, J.F., Galy, A., Weiler, S., Kaplan, J., Hughes, M.R., Ko, M.S. Genomics (2000) [Pubmed]
  2. Molecular characterisation of mouse and human TSSC6: evidence that TSSC6 is a genuine member of the tetraspanin superfamily and is expressed specifically in haematopoietic organs. Robb, L., Tarrant, J., Groom, J., Ibrahim, M., Li, R., Borobakas, B., Wright, M.D. Biochim. Biophys. Acta (2001) [Pubmed]
 
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