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Gene Review

DCAF7  -  DDB1 and CUL4 associated factor 7

Homo sapiens

Synonyms: AN11, DDB1-and CUL4-associated factor 7, HAN11, SWAN-1, WD repeat-containing protein 68, ...
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High impact information on WDR68

  • In the present study, we purified the 3a-kinase from rabbit skeletal muscle and identified one constituent polypeptide as HAN11, a WD40 domain protein with unknown function [1].
  • We showed that HAN11 binds the FH2 actin binding domain of mDia1 and confirmed that HAN11 also interacts with DYRK1A [2].
  • We performed in situ hybridisation to compare expression of HAN11 with GLI1 and patched in mouse embryos [2].
  • HAN11 is the human homologue of AN11, which controls flavonoid synthesis in plants [2].
  • Wdr68 homologs appear to exist in all eukaryotic genomes [3].

Biological context of WDR68

  • Notably, we found that the Drosophila wdr68 homolog CG14614 could substitute for the vertebrate wdr68 gene even though insects lack the NC cell lineage [3].

Anatomical context of WDR68

  • AN11 was highly expressed in E10.5 mouse embryo limb buds, in an overlapping pattern with Ptc and GLI1 [2].
  • Wdr68 interacts with two minibrain-related kinases, Dyrk1a and Dyrk1b, required for embryonic growth and myotube differentiation, respectively [3].
  • We show that a GFP-Wdr68 fusion protein localizes to the nucleus with Dyrk1a in contrast to an engineered loss of function mutation Wdr68-T284F that no longer accumulated in the cell nucleus and failed to rescue wdr68 mutant animals [3].

Other interactions of WDR68

  • GLI1-dependent transcription is positively regulated by DYRK1A, which is reported to bind HAN11 [2].

Analytical, diagnostic and therapeutic context of WDR68


  1. Phosphorylation of Ser640 in muscle glycogen synthase by DYRK family protein kinases. Skurat, A.V., Dietrich, A.D. J. Biol. Chem. (2004) [Pubmed]
  2. HAN11 binds mDia1 and controls GLI1 transcriptional activity. Morita, K., Celso, C.L., Spencer-Dene, B., Zouboulis, C.C., Watt, F.M. J. Dermatol. Sci. (2006) [Pubmed]
  3. A zebrafish screen for craniofacial mutants identifies wdr68 as a highly conserved gene required for endothelin-1 expression. Nissen, R.M., Amsterdam, A., Hopkins, N. BMC Dev. Biol. (2006) [Pubmed]
  4. The an11 locus controlling flower pigmentation in petunia encodes a novel WD-repeat protein conserved in yeast, plants, and animals. de Vetten, N., Quattrocchio, F., Mol, J., Koes, R. Genes Dev. (1997) [Pubmed]
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