Disease relevance of Dental Caries

• Guy's 13 is a mouse monoclonal antibody that specifically recognizes the major cell-surface adhesion protein SA I/II of Streptococcus mutans, one of the major causative agents of dental caries [1].
• The structural integrity of immunoglobulin A (IgA), IgG, and IgM and lactoferrin in dental plaque fluid samples from two populations of Colombian children with contrasting levels of dental caries was examined by sodium dodecyl sulfate-polyacrylamide gel electrophoresis followed by electrophoretic transfer to nitrocellulose [2].
• Tonsillar application of formalin-killed cells of Streptococcus sobrinus reduces experimental dental caries in rabbits [3].
• The ability of Actinomyces naeslundii to convert sucrose to extracellular homopolymers of fructose and to catabolize these types of polymers is suspected to be a virulence trait that contributes to the initiation and progression of dental caries and periodontal diseases [4].
• Proper dosage of dietary fluoride supplements is important for children without access to optimally fluoridated water to balance dental caries prevention and risks of dental fluorosis [5].

Psychiatry related information on Dental Caries

• Physicians' roles in preventing dental caries in preschool children: a summary of the evidence for the U.S. Preventive Services Task Force [6].
• Clinical manifestations of affected members included short stature, osteoporosis, severe dental caries, and various neurological abnormalities, such as mental retardation, depression, dysarthria, hyperreflexia, and ataxic gait [7].

High impact information on Dental Caries

• OBJECTIVE: To examine the relationship between dental caries and serum cotinine levels [8].
• Editorial: Value of fluoride supplements in prevention of dental caries [9].
• The sugars implicated in dental caries, in decreasing order of cariogenicity, are sucrose, glucose, and fructose; brown sugars are as cariogenic as white [10].
• When MPM-2 (0.7-1.4 micrograms per oocyte) was injected into oocytes prior to progesterone stimulation, MPF activity failed to appear and induction of maturation was inhibited as judged by both germinal-vesicle breakdown and white-spot formation [11].
• Xylitol and dental caries [12].

Chemical compound and disease context of Dental Caries

• In addition, a therapeutic and preventive effect for xylitol in human and animal dental caries has been demonstrated [13].
• The reductions in dental caries and lesions were greater on smooth dental surfaces than on occlusal surfaces, which might be explained as interference with adherence phenomena demonstrated by S. mutans [14].
• The beneficial effect of xylitol, mannitol, sorbitol, and fructose in decreasing order has been well documented in the prevention of dental caries in animals and in humans [13].
• The lipopolysaccharide and beta-1,3-glucan binding protein gene is upregulated in white spot virus-infected shrimp (Penaeus stylirostris) [15].
• Nox-1 from Streptococcus mutans, the bacteria which cause dental caries, was previously identified as an H2O2-forming reduced nicotinamide adenine dinucleotide (NADH) oxidase [16].

Biological context of Dental Caries

• These results clearly suggest that yIgG to S. mutants CA-GTase specifically inhibited a virulence factor of this organism, i.e., insoluble glucan-synthesizing CA-GTase, resulting in a significant reduction in the development of dental caries [17].
• Specific-pathogen-free rats which had been infected with S. mutans 6715 and fed a diet containing 56% palatinose did not develop significant dental caries [18].
• Dr. Neil Goldsworthy had a profound effect on the development of dental research in the biological sciences in Australia, including measures for the prevention of dental caries [19].
• Identification of the thymidylate synthase within the genome of white spot syndrome virus [20].
• Reactionary dentinogenesis during dental caries probably results from solubilization of growth factors, TGF-beta in particular, from the dentine matrix which then are responsible for initiating the stimulatory effect on the odontoblasts [21].

Anatomical context of Dental Caries

• A bi-annual professional application of APF foam was effective in reducing the increment of dental caries in the primary teeth [22].
• Failure to demonstrate an association between enamel fluoride concentration and dental caries in the deciduous dentition [23].
• High levels of pro-alpha 2(I)mRNA expression were also present in those odontoblasts which had elaborated new dentin matrix in response to dental caries [24].
• Because the dental pulp is frequently infected by oral bacteria due to dental decay, in this study, we examined whether lipopolysaccharide (LPS) and tumor necrosis factor (TNF) activated the immunologic transcription factor nuclear factor kappa B (NF-kappaB) in DPSCs [25].
• Collagen is a major constituent of dentine and it is possible that the association between myopia and dental caries is a sign of a common collagen defect [26].

Gene context of Dental Caries

• RESULTS: Mice homozygous for the rd12 mutation showed small punctate white spots on fundus examination at 5 months of age [27].
• The ORF wsv112 of shrimp white spot syndrome virus (WSSV) was predicted to encode a protein with five conserved motifs at its N-terminus characteristics of dUTPases [28].
• Streptococcus mutans produces a number of extracellular sucrose-metabolizing enzymes that contribute to the ability of the organism to cause dental caries, including three glucosyltransferases, the products of the gtfB, gtfC and gtfD genes, and a fructosyltransferase, encoded by the ftf gene [29].
• Dental practitioners and parents should consider ADHD to be a condition that may affect children's dental caries experience [30].
• PCNA-positive pulp cells were detected only in advanced dental caries (grades 3 and 4), and the difference in immuno-positive rate was significant between the two grades (p <0.001) [31].

Analytical, diagnostic and therapeutic context of Dental Caries

• OPTIONS: Systemic fluoride administration, professionally administered fluoride, use of fluoride mouth rinses, fissure sealants, oral-hygiene practices, dietary practices, identification of groups at a high risk of dental caries, and early diagnosis and treatment [32].
• In the present study we explored the effects of sodium benzoate and fluoride in combination and alone on dental caries in our animal model [33].
• The treatment effect was strongest within the high-risk category: two subjects had to be treated with intensive care for 3 yr to avoid restorative treatment of dental caries by the age of 5 yr in one subject (number needed to treat (NNT) = 2.0; 95% CI 1.4-3.8) [34].
• Is attention-deficit hyperactivity disorder a risk factor for dental caries? A case-control study [30].
• CONCLUSION: 16S rRNA gene PCR-RFLP, using HpaII and HaeIII, together with SDS-PAGE protein profiles could be an alternative method for the identification of oral Lactobacillus strains to species level, and may be applicable for large-scale studies on the association of Lactobacillus to dental caries [35].

References