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Gene Review

APBB3  -  amyloid beta (A4) precursor protein...

Homo sapiens

Synonyms: Amyloid beta A4 precursor protein-binding family B member 3, FE65L2, Fe65L2, Protein Fe65-like 2, SRA
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Psychiatry related information on APBB3

  • Characterization of the Fe65L2 gene structure will be useful in the linkage analysis and search for mutations in the Fe65L2 gene in patients with Alzheimer's disease [1].

High impact information on APBB3


Biological context of APBB3

  • In the present study, we cloned and characterized two novel isoforms of Fe65L2, designated I-214 and I-245, which are produced by alternative splicing of the RNA [4].
  • Genome structure and chromosomal mapping of the gene for Fe65L2 interacting with Alzheimer's beta-amyloid precursor protein [1].
  • Radiation hybrid mapping revealed that the Fe65L2 gene is on chromosome 5 between markers SHGC-9824 (D5S2374) and SHGC-8489 (D5S2569) [1].

Anatomical context of APBB3

  • In HEK-293 cells, Fe65L2 was expressed in the nucleus and cytosol, whereas I-245 and I-214 were localized exclusively to the nucleus [4].

Associations of APBB3 with chemical compounds


Other interactions of APBB3


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