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Gene Review:

APBB3 - amyloid beta (A4) precursor protein...

Homo sapiens

Synonyms: Amyloid beta A4 precursor protein-binding family B member 3, FE65L2, Fe65L2, Protein Fe65-like 2, SRA

Tanahashi, H. et al., Tanahashi, H. et al., Bruni, P. et al., Tanahashi, H. et al., Tanahashi, H. et al.

Tanahashi, Tabira, Tanahashi, Tabira, Tanahashi, Tabira,

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Psychiatry related information on APBB3

Characterization of the Fe65L2 gene structure will be useful in the linkage analysis and search for mutations in the Fe65L2 gene in patients with Alzheimer's disease [1].

High impact information on APBB3

c954C-->T polymorphism in the Fe65L2 gene is associated with early-onset Alzheimer's disease [2].
In neuronal PC12 cells, the overexpression of Fe65 or of Fe65L1 and Fe65L2 blocks cell cycle, as observed in fibroblasts, but thymidine supplementation to culture medium does not revert this block, thus suggesting that Fe65 proteins induce in neuronal cells a gene expression program different from that activated in fibroblasts [3].
These results suggest that Fe65L2 affects Abeta production and a possible regulation of Fe65L2 function by alternative splicing [4].
Characterization of an amyloid precursor protein-binding protein Fe65L2 and its novel isoforms lacking phosphotyrosine-interaction domains [4].
Human Fe65L2 is a member of the Fe65 protein family, which interacts with amyloid precursor protein (APP) [4].

Biological context of APBB3

In the present study, we cloned and characterized two novel isoforms of Fe65L2, designated I-214 and I-245, which are produced by alternative splicing of the RNA [4].
Genome structure and chromosomal mapping of the gene for Fe65L2 interacting with Alzheimer's beta-amyloid precursor protein [1].
Radiation hybrid mapping revealed that the Fe65L2 gene is on chromosome 5 between markers SHGC-9824 (D5S2374) and SHGC-8489 (D5S2569) [1].

Anatomical context of APBB3

In HEK-293 cells, Fe65L2 was expressed in the nucleus and cytosol, whereas I-245 and I-214 were localized exclusively to the nucleus [4].

Associations of APBB3 with chemical compounds

Fe65L2 contains an N-terminal WW (Trp-Trp) domain followed by two phosphotyrosine-interaction domains, and consists of 486 amino acids [4].

Other interactions of APBB3

Molecular cloning of human Fe65L2 and its interaction with the Alzheimer's beta-amyloid precursor protein [5].

References

Genome structure and chromosomal mapping of the gene for Fe65L2 interacting with Alzheimer's beta-amyloid precursor protein. Tanahashi, H., Tabira, T. Biochem. Biophys. Res. Commun. (1999) [Pubmed]
c954C-->T polymorphism in the Fe65L2 gene is associated with early-onset Alzheimer's disease. Tanahashi, H., Asada, T., Tabira, T. Ann. Neurol. (2002) [Pubmed]
Fe65, a ligand of the Alzheimer's beta-amyloid precursor protein, blocks cell cycle progression by down-regulating thymidylate synthase expression. Bruni, P., Minopoli, G., Brancaccio, T., Napolitano, M., Faraonio, R., Zambrano, N., Hansen, U., Russo, T. J. Biol. Chem. (2002) [Pubmed]
Characterization of an amyloid precursor protein-binding protein Fe65L2 and its novel isoforms lacking phosphotyrosine-interaction domains. Tanahashi, H., Tabira, T. Biochem. J. (2002) [Pubmed]
Molecular cloning of human Fe65L2 and its interaction with the Alzheimer's beta-amyloid precursor protein. Tanahashi, H., Tabira, T. Neurosci. Lett. (1999) [Pubmed]

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