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Gene Review

umuD  -  DNA polymerase V subunit UmuD

Escherichia coli CFT073

 
 
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Disease relevance of umuD

  • Escherichia coli possesses two members of the Y family, DNA pol IV (DinB) and DNA pol V (UmuD'(2)C), and several regulatory factors, including those encoded by the umuD gene that influence the activity of UmuC [1].
  • Induction and cleavage of Salmonella typhimurium UmuD protein [2].
 

High impact information on umuD

  • The UmuD protein shares homology with LexA, the repressor of SOS-regulated loci, and similarly undergoes a facilitated autodigestion on interaction with the RecA/single-stranded DNA nucleoprotein filaments formed after a cell experiences DNA damage [3].
  • The recently described crystal structure of the Escherichia coli UmuD' protein (the posttranslational cleavage product of the UmuD protein) suggests, however, that the region of the protein corresponding to the cleavage site is at least 50 A away from the catalytic active site [4].
  • RecA protein-dependent cleavage of UmuD protein and SOS mutagenesis [5].
  • Furthermore, this proline residue appears to result in a UmuD protein that is a much better substrate for intermolecular cleavage [6].
  • The umuD open reading frame is intact, but it is 1.5 times the size of other umuD genes and has an extra 5' region that lacks homology to known umuD genes [7].
 

Biological context of umuD

  • The umuD mutation did not affect the growth rate or survival after UV-induced DNA damage [7].
 

Analytical, diagnostic and therapeutic context of umuD

References

  1. Characterization of Escherichia coli translesion synthesis polymerases and their accessory factors. Beuning, P.J., Simon, S.M., Godoy, V.G., Jarosz, D.F., Walker, G.C. Meth. Enzymol. (2006) [Pubmed]
  2. Induction and cleavage of Salmonella typhimurium UmuD protein. Woodgate, R., Levine, A.S., Koch, W.H., Cebula, T.A., Eisenstadt, E. Mol. Gen. Genet. (1991) [Pubmed]
  3. A model for a umuDC-dependent prokaryotic DNA damage checkpoint. Opperman, T., Murli, S., Smith, B.T., Walker, G.C. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  4. Intermolecular cleavage by UmuD-like mutagenesis proteins. McDonald, J.P., Frank, E.G., Levine, A.S., Woodgate, R. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  5. RecA protein-dependent cleavage of UmuD protein and SOS mutagenesis. Shinagawa, H., Iwasaki, H., Kato, T., Nakata, A. Proc. Natl. Acad. Sci. U.S.A. (1988) [Pubmed]
  6. Regulation of UmuD cleavage: role of the amino-terminal tail. McDonald, J.P., Maury, E.E., Levine, A.S., Woodgate, R. J. Mol. Biol. (1998) [Pubmed]
  7. A constitutively expressed, truncated umuDC operon regulates the recA-dependent DNA damage induction of a gene in Acinetobacter baylyi strain ADP1. Hare, J.M., Perkins, S.N., Gregg-Jolly, L.A. Appl. Environ. Microbiol. (2006) [Pubmed]
  8. Escherichia coli umuDC mutants: DNA sequence alterations and UmuD cleavage. Koch, W.H., Ennis, D.G., Levine, A.S., Woodgate, R. Mol. Gen. Genet. (1992) [Pubmed]
 
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