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Gene Review

HMG20A  -  high mobility group 20A

Homo sapiens

Synonyms: FLJ10739, HMG box-containing protein 20A, HMG domain-containing protein 1, HMG domain-containing protein HMGX1, HMGX1, ...
 
 
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Disease relevance of HMG20A

  • Finally, in cells expressing a CP77 deletion protein (amino acids 277 to 668) or a DeltaANK5 mutant that did not support vaccinia virus growth and did not contain the HMG20A binding site, HMG20A remained bound to viral DNA, demonstrating that the binding of CP77 to HMG20A is essential for its host range function [1].
  • A poxvirus host range protein, CP77, binds to a cellular protein, HMG20A, and regulates its dissociation from the vaccinia virus genome in CHO-K1 cells [1].
 

High impact information on HMG20A

  • After VV-hr virus infection of CHO-K1 cells, HMG20A was translocated from the nucleus to viral factories and bound to the viral genome via the HMG box region [1].
  • HMG20A maps to chromosome 15q24 (near D15S1227) and HMG20B to 19p13.3 (between D19S209 and D19S216) [2].
 

Biological context of HMG20A

References

  1. A poxvirus host range protein, CP77, binds to a cellular protein, HMG20A, and regulates its dissociation from the vaccinia virus genome in CHO-K1 cells. Hsiao, J.C., Chao, C.C., Young, M.J., Chang, Y.T., Cho, E.C., Chang, W. J. Virol. (2006) [Pubmed]
  2. HMG20A and HMG20B map to human chromosomes 15q24 and 19p13.3 and constitute a distinct class of HMG-box genes with ubiquitous expression. Sumoy, L., Carim, L., Escarceller, M., Nadal, M., Gratacòs, M., Pujana, M.A., Estivill, X., Peral, B. Cytogenet. Cell Genet. (2000) [Pubmed]
 
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