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Gene Review:

HMG20B - high mobility group 20B

Homo sapiens

Synonyms: BRAF25, BRAF35, BRCA2-associated factor 35, HMG box-containing protein 20B, HMG domain-containing protein 2, ...

Hakimi, M.A. et al., Wang, C. et al., Wang, C. et al., Lee, Y.M. et al., Sumoy, L. et al., et al.

Wang, McCarty, Balazs, Li, Steiner, Sumoy, Carim, Escarceller, Nadal, Gratacòs, Pujana, Estivill, Peral, Wang, McCarty, Balazs, Li, Steiner,

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of HMG20B

Therefore, the expression of BRAF25 was gradually lost in prostate cancer [1].
Because of the high incidence of genetic links of prostate cancer to breast and ovarian cancers, we investigated the BRAF25 expression in the prostate specimens [1].
Immunohistochemical analysis using antibodies specific for BRAF25 revealed a strong immunostaining in sections of the benign prostatic hyperplasia (BPH) [1].

High impact information on HMG20B

Biochemical analysis revealed the presence of a smaller core-BRAF35 complex devoid of BRCA2 [2].
A core-BRAF35 complex containing histone deacetylase mediates repression of neuronal-specific genes [2].
Expression of BRAF35 containing a single point mutation in the HMG domain of the protein abrogated REST-mediated transcriptional repression [2].
Genes up-regulated in the utricle included SMAD2, KIT, beta-AMYLOID, LOC51637, HMG20B and CRIP2 [3].
Western blot analysis using antibodies specific for BRAF25 revealed the presence of BRAF25 in human prostate cancer cells [4].

Biological context of HMG20B

HMG20A maps to chromosome 15q24 (near D15S1227) and HMG20B to 19p13.3 (between D19S209 and D19S216) [5].
HMG20A and HMG20B map to human chromosomes 15q24 and 19p13.3 and constitute a distinct class of HMG-box genes with ubiquitous expression [5].
BRCA2 protein exists in a large multi-protein complex from which a novel structural DNA binding protein BRCA2-associated factor 35 (BRAF35) has been isolated [4].

Anatomical context of HMG20B

Subcellular fractionation, DNA-affinity column chromatography, and electrophoretic mobility shift assays showed that human SMARCE1r was associated with the nuclear matrix and that it possessed DNA binding activity, as expected [6].

Physical interactions of HMG20B

This protein is BRCA2-associated factor 35 (BRAF35) containing a non-specific DNA binding high-mobility-group domain and a kinesin-like coiled-coil domain [7].

Other interactions of HMG20B

BRAF35, a structural DNA-binding protein, initially was identified as a component of a large BRCA2-containing complex [2].
The co-fractionation experiment revealed that KIF4 and BRAF35 were present in a complex of approx. 540 kDa [7].
BRAF25 contains a truncated high mobility group domain, a kinesin-like coiled-coil domain and multiple Src homology 2 (SH2) motifs [4].

References

Immunohistological detection of BRAF25 in human prostate tumor and cancer specimens. Wang, C., McCarty, I.M., Balazs, L., Li, Y., Steiner, M.S. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
A core-BRAF35 complex containing histone deacetylase mediates repression of neuronal-specific genes. Hakimi, M.A., Bochar, D.A., Chenoweth, J., Lane, W.S., Mandel, G., Shiekhattar, R. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
Gene expression differences in quiescent versus regenerating hair cells of avian sensory epithelia: implications for human hearing and balance disorders. Hawkins, R.D., Bashiardes, S., Helms, C.A., Hu, L., Saccone, N.L., Warchol, M.E., Lovett, M. Hum. Mol. Genet. (2003) [Pubmed]
Cloning a cDNA encoding an alternatively spliced protein of BRCA2-associated factor 35. Wang, C., McCarty, I.M., Balazs, L., Li, Y., Steiner, M.S. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
HMG20A and HMG20B map to human chromosomes 15q24 and 19p13.3 and constitute a distinct class of HMG-box genes with ubiquitous expression. Sumoy, L., Carim, L., Escarceller, M., Nadal, M., Gratacòs, M., Pujana, M.A., Estivill, X., Peral, B. Cytogenet. Cell Genet. (2000) [Pubmed]
Characterization of human SMARCE1r high-mobility-group protein. Lee, Y.M., Shin, H., Choi, W., Ahn, S., Kim, W. Biochim. Biophys. Acta (2002) [Pubmed]
Association of human kinesin superfamily protein member 4 with BRCA2-associated factor 35. Lee, Y.M., Kim, W. Biochem. J. (2003) [Pubmed]

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