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Gene Review

HMG20B  -  high mobility group 20B

Homo sapiens

Synonyms: BRAF25, BRAF35, BRCA2-associated factor 35, HMG box-containing protein 20B, HMG domain-containing protein 2, ...
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Disease relevance of HMG20B


High impact information on HMG20B


Biological context of HMG20B


Anatomical context of HMG20B

  • Subcellular fractionation, DNA-affinity column chromatography, and electrophoretic mobility shift assays showed that human SMARCE1r was associated with the nuclear matrix and that it possessed DNA binding activity, as expected [6].

Physical interactions of HMG20B


Other interactions of HMG20B

  • BRAF35, a structural DNA-binding protein, initially was identified as a component of a large BRCA2-containing complex [2].
  • The co-fractionation experiment revealed that KIF4 and BRAF35 were present in a complex of approx. 540 kDa [7].
  • BRAF25 contains a truncated high mobility group domain, a kinesin-like coiled-coil domain and multiple Src homology 2 (SH2) motifs [4].


  1. Immunohistological detection of BRAF25 in human prostate tumor and cancer specimens. Wang, C., McCarty, I.M., Balazs, L., Li, Y., Steiner, M.S. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
  2. A core-BRAF35 complex containing histone deacetylase mediates repression of neuronal-specific genes. Hakimi, M.A., Bochar, D.A., Chenoweth, J., Lane, W.S., Mandel, G., Shiekhattar, R. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  3. Gene expression differences in quiescent versus regenerating hair cells of avian sensory epithelia: implications for human hearing and balance disorders. Hawkins, R.D., Bashiardes, S., Helms, C.A., Hu, L., Saccone, N.L., Warchol, M.E., Lovett, M. Hum. Mol. Genet. (2003) [Pubmed]
  4. Cloning a cDNA encoding an alternatively spliced protein of BRCA2-associated factor 35. Wang, C., McCarty, I.M., Balazs, L., Li, Y., Steiner, M.S. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
  5. HMG20A and HMG20B map to human chromosomes 15q24 and 19p13.3 and constitute a distinct class of HMG-box genes with ubiquitous expression. Sumoy, L., Carim, L., Escarceller, M., Nadal, M., Gratacòs, M., Pujana, M.A., Estivill, X., Peral, B. Cytogenet. Cell Genet. (2000) [Pubmed]
  6. Characterization of human SMARCE1r high-mobility-group protein. Lee, Y.M., Shin, H., Choi, W., Ahn, S., Kim, W. Biochim. Biophys. Acta (2002) [Pubmed]
  7. Association of human kinesin superfamily protein member 4 with BRCA2-associated factor 35. Lee, Y.M., Kim, W. Biochem. J. (2003) [Pubmed]
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