The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

PRG3  -  proteoglycan 3

Homo sapiens

Synonyms: Eosinophil major basic protein homolog, MBP2, MBPH, Prepro-MBPH, Prepro-major basic protein homolog, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of PRG3

  • We have identified PRG3 (p53-responsive gene 3), which is induced specifically under p53-dependent apoptotic conditions in human colon cancer cells, and encodes a novel polypeptide of 373 amino acids with a predicted molecular mass of 40.5 kDa [1].

High impact information on PRG3

  • Interestingly, the calculated pI values for hMBPH and hMBP differed by >100-fold, with pI values of 8.7 and 11.4, respectively [2].
  • Reverse transcription-polymerase chain reaction detected transcription of hprepro-MBPH in bone marrow only, and this result was confirmed by analysis of a large cDNA data base (electronic Northern). hMBPH was isolated from human eosinophil granule lysates, and its identity was verified by amino acid sequencing and by mass spectrometry [2].
  • Unlike AIF, PRG3 localizes in the cytoplasm and its ectopic expression induces apoptosis [1].
  • PRG3 has significant homology to bacterial oxidoreductases and the apoptosis-inducing factor, AIF, and the gene was assigned to chromosome 10q21.3-q22 [1].
  • Thus, the human MBP and MBPH genes have diverged considerably, probably following a gene duplication event [3].

Biological context of PRG3


  1. A novel p53-inducible apoptogenic gene, PRG3, encodes a homologue of the apoptosis-inducing factor (AIF). Ohiro, Y., Garkavtsev, I., Kobayashi, S., Sreekumar, K.R., Nantz, R., Higashikubo, B.T., Duffy, S.L., Higashikubo, R., Usheva, A., Gius, D., Kley, N., Horikoshi, N. FEBS Lett. (2002) [Pubmed]
  2. A novel and highly divergent homolog of human eosinophil granule major basic protein. Plager, D.A., Loegering, D.A., Weiler, D.A., Checkel, J.L., Wagner, J.M., Clarke, N.J., Naylor, S., Page, S.M., Thomas, L.L., Akerblom, I., Cocks, B., Stuart, S., Gleich, G.J. J. Biol. Chem. (1999) [Pubmed]
  3. Comparative structure, proximal promoter elements, and chromosome location of the human eosinophil major basic protein genes. Plager, D.A., Weiler, D.A., Loegering, D.A., Johnson, W.B., Haley, L., Eddy, R.L., Shows, T.B., Gleich, G.J. Genomics (2001) [Pubmed]
WikiGenes - Universities