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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

PRG3  -  proteoglycan 3

Homo sapiens

Synonyms: Eosinophil major basic protein homolog, MBP2, MBPH, Prepro-MBPH, Prepro-major basic protein homolog, ...
 
 
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Disease relevance of PRG3

  • We have identified PRG3 (p53-responsive gene 3), which is induced specifically under p53-dependent apoptotic conditions in human colon cancer cells, and encodes a novel polypeptide of 373 amino acids with a predicted molecular mass of 40.5 kDa [1].
 

High impact information on PRG3

  • Interestingly, the calculated pI values for hMBPH and hMBP differed by >100-fold, with pI values of 8.7 and 11.4, respectively [2].
  • Reverse transcription-polymerase chain reaction detected transcription of hprepro-MBPH in bone marrow only, and this result was confirmed by analysis of a large cDNA data base (electronic Northern). hMBPH was isolated from human eosinophil granule lysates, and its identity was verified by amino acid sequencing and by mass spectrometry [2].
  • Unlike AIF, PRG3 localizes in the cytoplasm and its ectopic expression induces apoptosis [1].
  • PRG3 has significant homology to bacterial oxidoreductases and the apoptosis-inducing factor, AIF, and the gene was assigned to chromosome 10q21.3-q22 [1].
  • Thus, the human MBP and MBPH genes have diverged considerably, probably following a gene duplication event [3].
 

Biological context of PRG3

References

  1. A novel p53-inducible apoptogenic gene, PRG3, encodes a homologue of the apoptosis-inducing factor (AIF). Ohiro, Y., Garkavtsev, I., Kobayashi, S., Sreekumar, K.R., Nantz, R., Higashikubo, B.T., Duffy, S.L., Higashikubo, R., Usheva, A., Gius, D., Kley, N., Horikoshi, N. FEBS Lett. (2002) [Pubmed]
  2. A novel and highly divergent homolog of human eosinophil granule major basic protein. Plager, D.A., Loegering, D.A., Weiler, D.A., Checkel, J.L., Wagner, J.M., Clarke, N.J., Naylor, S., Page, S.M., Thomas, L.L., Akerblom, I., Cocks, B., Stuart, S., Gleich, G.J. J. Biol. Chem. (1999) [Pubmed]
  3. Comparative structure, proximal promoter elements, and chromosome location of the human eosinophil major basic protein genes. Plager, D.A., Weiler, D.A., Loegering, D.A., Johnson, W.B., Haley, L., Eddy, R.L., Shows, T.B., Gleich, G.J. Genomics (2001) [Pubmed]
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