Disease relevance of crc

• Role of the crc gene in catabolic repression of the Pseudomonas putida GPo1 alkane degradation pathway [1].
• The crc gene product was overexpressed in both P. aeruginosa and in E. coli, and the Crc protein was purified from both [2].

High impact information on crc

• Neither crc nor ptsN could relieve this repression [3].
• The presence of crc on a high-copy-number plasmid considerably increased Crc levels, but this impaired its ability to inhibit the alkane degradation pathway [4].
• On the contrary, a crc mutation known to stimulate expression of the ED enzymes causes the promoter to be less sensitive to glucose [5].
• Since under carbon limitation conditions the first signal is relieved but the second signal is not, we propose that modulation mediated by the cytochrome o ubiquinol oxidase is not classical catabolite repression control but rather a more general physiological control mechanism [6].
• BkdR levels were elevated in a P. putida crc mutant, but bkdR transcript levels were the same in both wild type and crc mutant [7].

Chemical compound and disease context of crc

• Inducibility of the TOL catabolic pathway in Pseudomonas putida (pWW0) growing on succinate in continuous culture: evidence of carbon catabolite repression control [8].

Biological context of crc

• However, crc mutants do not have a DNA repair phenotype, nor can the crc gene complement Escherichia coli DNA repair-deficient strains [2].
• Crc (catabolite repression control protein) was shown to be responsible for repression of bkd operon transcription in 2xYT [7].

References