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Gene Review

crc  -  catabolite repression control protein

Pseudomonas aeruginosa PAO1

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Disease relevance of crc


High impact information on crc

  • Instead, relief from As(III)-based oxidative stress is accomplished from the collective activities of ArsB, glutathione reductase, and the global regulator Crc [2].
  • We propose that nutritional cues are integrated by Crc as part of a signal transduction pathway that regulates biofilm development [3].
  • Because choline and glycine betaine may serve as carbon and energy sources in addition to conferring osmoprotection to P. aeruginosa, it seemed possible that induction of plcH is subject to catabolite repression control (CRC) by tricarboxylic cycle intermediates such as succinate [4].
  • However, a P. aeruginosa mutant decoupled in CRC exhibited a phenotype similar to that of the wild-type strain (PAO1) with respect to succinate-dependent repression of plcH expression [4].
  • This indicates that CRC of plcH functions by a distinct mechanism which differs from that regulating the glucose or mannitol catabolic pathway [4].

Chemical compound and disease context of crc


Biological context of crc


Associations of crc with chemical compounds

  • When a 0.3-kb AccI fragment was removed from the crc gene and replaced with a kanamycin resistance cassette, the interrupted crc gene no longer restored CRC to the mutant, and the mutant containing the interrupted gene no longer overproduced the 30,000-MW protein [1].
  • These results provide original evidence for a 30,000-MW protein encoded by crc+ that is required for wild-type CRC in P. aeruginosa and confirms earlier reports that the mode of CRC is cyclic AMP independent in this bacterium [1].
  • Selection for succinate-dependent, fluoroacetamide-resistant derivatives of the crc-10 mutant yielded three independent pseudorevertants containing suppressors that restored a degree of catabolite repression control [6].

Other interactions of crc


Analytical, diagnostic and therapeutic context of crc

  • Using phase-contrast microscopy, we found that a crc mutant only makes a dispersed monolayer of cells on a plastic surface but does not develop the dense monolayer punctuated by microcolonies typical of the wild-type strain [3].


  1. Cloning of a catabolite repression control (crc) gene from Pseudomonas aeruginosa, expression of the gene in Escherichia coli, and identification of the gene product in Pseudomonas aeruginosa. MacGregor, C.H., Wolff, J.A., Arora, S.K., Phibbs, P.V. J. Bacteriol. (1991) [Pubmed]
  2. Global analysis of cellular factors and responses involved in Pseudomonas aeruginosa resistance to arsenite. Parvatiyar, K., Alsabbagh, E.M., Ochsner, U.A., Stegemeyer, M.A., Smulian, A.G., Hwang, S.H., Jackson, C.R., McDermott, T.R., Hassett, D.J. J. Bacteriol. (2005) [Pubmed]
  3. The global carbon metabolism regulator Crc is a component of a signal transduction pathway required for biofilm development by Pseudomonas aeruginosa. O'Toole, G.A., Gibbs, K.A., Hager, P.W., Phibbs, P.V., Kolter, R. J. Bacteriol. (2000) [Pubmed]
  4. Osmoprotectant-dependent expression of plcH, encoding the hemolytic phospholipase C, is subject to novel catabolite repression control in Pseudomonas aeruginosa PAO1. Sage, A.E., Vasil, M.L. J. Bacteriol. (1997) [Pubmed]
  5. Succinate-mediated catabolite repression control on the production of glycine betaine catabolic enzymes in Pseudomonas aeruginosa PAO1 under low and elevated salinities. Diab, F., Bernard, T., Bazire, A., Haras, D., Blanco, C., Jebbar, M. Microbiology (Reading, Engl.) (2006) [Pubmed]
  6. Isolation and phenotypic characterization of Pseudomonas aeruginosa pseudorevertants containing suppressors of the catabolite repression control-defective crc-10 allele. Collier, D.N., Spence, C., Cox, M.J., Phibbs, P.V. FEMS Microbiol. Lett. (2001) [Pubmed]
  7. Two genes for carbohydrate catabolism are divergently transcribed from a region of DNA containing the hexC locus in Pseudomonas aeruginosa PAO1. Temple, L., Sage, A., Christie, G.E., Phibbs, P.V. J. Bacteriol. (1994) [Pubmed]
  8. Isolation and characterization of catabolite repression control mutants of Pseudomonas aeruginosa PAO. Wolff, J.A., MacGregor, C.H., Eisenberg, R.C., Phibbs, P.V. J. Bacteriol. (1991) [Pubmed]
  9. Effect of vfr mutation on global gene expression and catabolite repression control of Pseudomonas aeruginosa. Suh, S.J., Runyen-Janecky, L.J., Maleniak, T.C., Hager, P., MacGregor, C.H., Zielinski-Mozny, N.A., Phibbs, P.V., West, S.E. Microbiology (Reading, Engl.) (2002) [Pubmed]
  10. Cyclic adenosine 3',5'-monophosphate levels and activities of adenylate cyclase and cyclic adenosine 3',5'-monophosphate phosphodiesterase in Pseudomonas and Bacteroides. Siegel, L.S., Hylemon, P.B., Phibbs, P.V. J. Bacteriol. (1977) [Pubmed]
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