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Gene Review:

Mdmg1 - mandibular morphogenesis 1

Mus musculus

Synonyms: Mdmg-1

Slavkin, H.C., Chin, J.R. et al., Chai, Y. et al., Wang, Y.H. et al., Shum, L. et al., et al.

Chai, Jiang, Ito, Bringas, Han, Rowitch, Soriano, McMahon, Sucov,

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High impact information on Mdmg1

Fate of the mammalian cranial neural crest during tooth and mandibular morphogenesis [1].
Culture of day 10 mandibular explants with a hydroxamic acid metalloproteinase inhibitor, but not with inhibitors of metalloendopeptidases (thiorphan and phosphoramidon), serine proteinases (aprotinin), cysteine proteinases (leupeptin) and urokinase (amiloride), altered mandibular morphogenesis dramatically [2].
EGF abrogation-induced fusilli-form dysmorphogenesis of Meckel's cartilage during embryonic mouse mandibular morphogenesis in vitro [3].
Moreover, signaling from the pharyngeal endoderm has been shown to be important for mandibular morphogenesis [4].
In the present study the possible roles of BMP-7 in mediating inductive events during the initiation phase of odontogenesis and mandibular morphogenesis were investigated [5].

Anatomical context of Mdmg1

This review summarizes recent results using experimental embryology, organ culture, recombinant DNA technology, and immunocytology to elucidate mechanisms responsive to instructive epithelial-mesenchymal interactions associated with mandibular morphogenesis, tooth positional information, and subsequent tooth crown and initial root development [6].

References

Fate of the mammalian cranial neural crest during tooth and mandibular morphogenesis. Chai, Y., Jiang, X., Ito, Y., Bringas, P., Han, J., Rowitch, D.H., Soriano, P., McMahon, A.P., Sucov, H.M. Development (2000) [Pubmed]
Matrix metalloproteinases regulate morphogenesis, migration and remodeling of epithelium, tongue skeletal muscle and cartilage in the mandibular arch. Chin, J.R., Werb, Z. Development (1997) [Pubmed]
EGF abrogation-induced fusilli-form dysmorphogenesis of Meckel's cartilage during embryonic mouse mandibular morphogenesis in vitro. Shum, L., Sakakura, Y., Bringas, P., Luo, W., Snead, M.L., Mayo, M., Crohin, C., Millar, S., Werb, Z., Buckley, S. Development (1993) [Pubmed]
Threshold-specific requirements for Bmp4 in mandibular development. Liu, W., Selever, J., Murali, D., Sun, X., Brugger, S.M., Ma, L., Schwartz, R.J., Maxson, R., Furuta, Y., Martin, J.F. Dev. Biol. (2005) [Pubmed]
Effects of BMP-7 on mouse tooth mesenchyme and chick mandibular mesenchyme. Wang, Y.H., Rutherford, B., Upholt, W.B., Mina, M. Dev. Dyn. (1999) [Pubmed]
Molecular determinants during dental morphogenesis and cytodifferentiation: a review. Slavkin, H.C. J. Craniofac. Genet. Dev. Biol. (1991) [Pubmed]

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