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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
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Disease relevance of Odontogenesis


High impact information on Odontogenesis

  • Here we have identified Pax9 as a marker for prospective tooth mesenchyme prior to the first morphological manifestation of odontogenesis [2].
  • Thus, the cleidocranial bone formation, as mediated by intramembranous ossification, may require a higher level of RUNX2 than does skeletogenesis (mediated by endochondral ossification), as well as odontogenesis (involving still different complex processes) [3].
  • These results show that, although latent, the early signaling pathways involved in odontogenesis remain inducible in Aves and suggest that loss of odontogenic Bmp4 expression may be responsible for the early arrest of tooth development in living birds [4].
  • Although previous studies have shown E-cadherin expression during rodent or human odontogenesis, there is no equivalent study available on N-cadherin expression in dental tissues [5].
  • To understand the molecular mechanisms underlying the spatiotemporal expression of the amelogenin gene during odontogenesis, the mouse amelogenin promoter was systematically analyzed in mouse ameloblast-like LS8 cells [6].

Biological context of Odontogenesis


Anatomical context of Odontogenesis


Associations of Odontogenesis with chemical compounds


Gene context of Odontogenesis


Analytical, diagnostic and therapeutic context of Odontogenesis


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  2. Antagonistic interactions between FGF and BMP signaling pathways: a mechanism for positioning the sites of tooth formation. Neubüser, A., Peters, H., Balling, R., Martin, G.R. Cell (1997) [Pubmed]
  3. Functional analysis of RUNX2 mutations in Japanese patients with cleidocranial dysplasia demonstrates novel genotype-phenotype correlations. Yoshida, T., Kanegane, H., Osato, M., Yanagida, M., Miyawaki, T., Ito, Y., Shigesada, K. Am. J. Hum. Genet. (2002) [Pubmed]
  4. Conservation of early odontogenic signaling pathways in Aves. Chen, Y., Zhang, Y., Jiang, T.X., Barlow, A.J., St Amand, T.R., Hu, Y., Heaney, S., Francis-West, P., Chuong, C.M., Maas, R. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  5. E- and N-cadherin distribution in developing and functional human teeth under normal and pathological conditions. Heymann, R., About, I., Lendahl, U., Franquin, J.C., Obrink, B., Mitsiadis, T.A. Am. J. Pathol. (2002) [Pubmed]
  6. Identification of CCAAT/enhancer-binding protein alpha as a transactivator of the mouse amelogenin gene. Zhou, Y.L., Snead, M.L. J. Biol. Chem. (2000) [Pubmed]
  7. Reciprocal temporospatial patterns of Msx2 and Osteocalcin gene expression during murine odontogenesis. Bidder, M., Latifi, T., Towler, D.A. J. Bone Miner. Res. (1998) [Pubmed]
  8. Cranial neural crest-derived mesenchymal proliferation is regulated by Msx1-mediated p19(INK4d) expression during odontogenesis. Han, J., Ito, Y., Yeo, J.Y., Sucov, H.M., Maas, R., Chai, Y. Dev. Biol. (2003) [Pubmed]
  9. Ectoderm-targeted overexpression of the glucocorticoid receptor induces hypohidrotic ectodermal dysplasia. Cascallana, J.L., Bravo, A., Donet, E., Leis, H., Lara, M.F., Paramio, J.M., Jorcano, J.L., Pérez, P. Endocrinology (2005) [Pubmed]
  10. Polarizing activity, Sonic hedgehog, and tooth development in embryonic and postnatal mouse. Koyama, E., Yamaai, T., Iseki, S., Ohuchi, H., Nohno, T., Yoshioka, H., Hayashi, Y., Leatherman, J.L., Golden, E.B., Noji, S., Pacifici, M. Dev. Dyn. (1996) [Pubmed]
  11. Expression of Dlx genes during the development of the zebrafish pharyngeal dentition: evolutionary implications. Borday-Birraux, V., Van der Heyden, C., Debiais-Thibaud, M., Verreijdt, L., Stock, D.W., Huysseune, A., Sire, J.Y. Evol. Dev. (2006) [Pubmed]
  12. Sonic hedgehog regulates epithelial proliferation and cell survival in the developing tooth germ. Cobourne, M.T., Hardcastle, Z., Sharpe, P.T. J. Dent. Res. (2001) [Pubmed]
  13. In vitro effects of calcitonin and/or parathyroid hormone on odontogenesis of mouse embryonic molars. Sakakura, Y., Fujiwara, N., Sugawara, M., Nawa, T. J. Dent. Res. (1989) [Pubmed]
  14. Effect of growth hormone on the distribution of decorin and biglycan during odontogenesis in the rat incisor. Zhang, C.Z., Li, H., Bartold, P.M., Young, W.G., Waters, M.J. J. Dent. Res. (1995) [Pubmed]
  15. Immunolocalization of heat shock protein 27 in developing jaw bones and tooth germs of human fetuses. Leonardi, R., Barbato, E., Paganelli, C., Lo Muzio, L. Calcif. Tissue Int. (2004) [Pubmed]
  16. Perlecan, a basement membrane-type heparan sulfate proteoglycan, in the enamel organ: its intraepithelial localization in the stellate reticulum. Ida-Yonemochi, H., Ohshiro, K., Swelam, W., Metwaly, H., Saku, T. J. Histochem. Cytochem. (2005) [Pubmed]
  17. The effect of fluoride on the developing mineralized tissues. Robinson, C., Kirkham, J. J. Dent. Res. (1990) [Pubmed]
  18. Cyclophosphamide-induced changes in rodent odontogenesis. A light- and electron-microscopic study. Orams, H.J. Cell Tissue Res. (1983) [Pubmed]
  19. Expression of nuclear retinoic acid receptors during mouse odontogenesis. Bloch-Zupan, A., Décimo, D., Loriot, M., Mark, M.P., Ruch, J.V. Differentiation (1994) [Pubmed]
  20. Postnatal effects of nicotine on incisor development of albino mouse. Saad, A.Y. J. Oral Pathol. Med. (1990) [Pubmed]
  21. Morphological classification of dental lesions induced by various antitumor drugs in mice. Satoh, H., Uesugi, Y., Kawabata, T., Mori, K., Fujii, F., Kashimoto, Y., Kajimura, T., Furuhama, K. Toxicologic pathology. (2001) [Pubmed]
  22. Delta-notch signaling in odontogenesis: correlation with cytodifferentiation and evidence for feedback regulation. Mitsiadis, T.A., Hirsinger, E., Lendahl, U., Goridis, C. Dev. Biol. (1998) [Pubmed]
  23. Expression and function of FGFs-4, -8, and -9 suggest functional redundancy and repetitive use as epithelial signals during tooth morphogenesis. Kettunen, P., Thesleff, I. Dev. Dyn. (1998) [Pubmed]
  24. Effects of BMP-7 on mouse tooth mesenchyme and chick mandibular mesenchyme. Wang, Y.H., Rutherford, B., Upholt, W.B., Mina, M. Dev. Dyn. (1999) [Pubmed]
  25. Opg, Rank, and Rankl in tooth development: co-ordination of odontogenesis and osteogenesis. Ohazama, A., Courtney, J.M., Sharpe, P.T. J. Dent. Res. (2004) [Pubmed]
  26. Expression of the transcription factors Otlx2, Barx1 and Sox9 during mouse odontogenesis. Mitsiadis, T.A., Mucchielli, M.L., Raffo, S., Proust, J.P., Koopman, P., Goridis, C. Eur. J. Oral Sci. (1998) [Pubmed]
  27. An immunocytochemical study of the innervation of developing human fetal teeth using protein gene product 9.5 (PGP 9.5). Christensen, L.R., Janas, M.S., Møllgård, K., Kjaer, I. Arch. Oral Biol. (1993) [Pubmed]
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