Disease relevance of Odontogenesis

• They are necessary for normal odontogenesis and excess retinol alters the pattern of odontogenesis producing supernumerary buds of the dental lamina in the diastema region of the mouse mandible [1].

High impact information on Odontogenesis

• Here we have identified Pax9 as a marker for prospective tooth mesenchyme prior to the first morphological manifestation of odontogenesis [2].
• Thus, the cleidocranial bone formation, as mediated by intramembranous ossification, may require a higher level of RUNX2 than does skeletogenesis (mediated by endochondral ossification), as well as odontogenesis (involving still different complex processes) [3].
• These results show that, although latent, the early signaling pathways involved in odontogenesis remain inducible in Aves and suggest that loss of odontogenic Bmp4 expression may be responsible for the early arrest of tooth development in living birds [4].
• Although previous studies have shown E-cadherin expression during rodent or human odontogenesis, there is no equivalent study available on N-cadherin expression in dental tissues [5].
• To understand the molecular mechanisms underlying the spatiotemporal expression of the amelogenin gene during odontogenesis, the mouse amelogenin promoter was systematically analyzed in mouse ameloblast-like LS8 cells [6].

Biological context of Odontogenesis

• Reciprocal temporospatial patterns of Msx2 and Osteocalcin gene expression during murine odontogenesis [7].
• Attenuation of p19(INK4d) in Msx1 null mutant mandibular explants restores mitotic activity in the dental mesenchyme, demonstrating the functional significance of Msx1-mediated p19(INK4d) expression in regulating CNC cell proliferation during odontogenesis [8].
• These phenotypic features appear to be mediated specifically by ligand-activated GR because the synthetic analog dexamethasone induced similar defects in epithelial morphogenesis, including odontogenesis, in wild-type mice [9].
• Given its subsequent association with differentiating ameloblasts, Shh probably participates also in cytogenetic events during odontogenesis [10].
• The latter type of difference may reflect the highly specialized dentition of the mouse relative to that of the zebrafish, and/or genome duplication in the zebrafish lineage facilitating a redistribution of Dlx gene function during odontogenesis [11].

Anatomical context of Odontogenesis

• Thus, Shh has dual roles in early odontogenesis, first in bud formation by stimulating epithelial proliferation, and second in the development of cap-stage tooth germs by increasing epithelial cell survival [12].
• PTH (1 unit/mL) inhibited the odontogenesis of the cultured molars during the designated culture periods (two and four days), while CT (0.5 unit/mL) stimulated odontogenesis [13].
• Effect of growth hormone on the distribution of decorin and biglycan during odontogenesis in the rat incisor [14].
• To determine whether Hsp27 is involved during craniofacial development and odontogenesis, its expression was studied through immunohistochemistry of developing jaw bone as well as the odontogenesis of heads from human fetuses [15].
• The localization and biosynthesis of perlecan, a basement membrane-type heparan sulfate proteoglycan, were studied in developing tooth germs by using murine molars in neonatal and postnatal stages and primary cultured cells of the enamel organ and dental papilla to demonstrate the role of perlecan in normal odontogenesis [16].

Associations of Odontogenesis with chemical compounds

• Little effect has been observed on the modulation of gene expression as far as odontogenesis is concerned, although there is evidence that fluoride could be osteogenic in both embryonic and adult tissues [17].
• Cyclophosphamide-induced changes in rodent odontogenesis. A light- and electron-microscopic study [18].
• Expression of nuclear retinoic acid receptors during mouse odontogenesis [19].
• Histologically, the processes of odontogenesis appeared retarded in nicotine treated animals, whereas the control group demonstrated normal dentin and enamel formation [20].
• ADR- or MMC-induced lesions were defined by abnormal structure of the apical aspect of the tooth and irregular odontogenesis, lasting for a long period (persistent apical injury) [21].

Gene context of Odontogenesis

• Here we report on the expression and regulation of Delta1, a transmembrane ligand of the Notch receptors, during mouse odontogenesis [22].
• The coexpression of Fgfs with other signaling molecules including Shh and several Bmps and their partly similar effects suggest that the FGFs participate in the signaling networks during odontogenesis [23].
• In the present study the possible roles of BMP-7 in mediating inductive events during the initiation phase of odontogenesis and mandibular morphogenesis were investigated [24].
• Opg, Rank, and Rankl in tooth development: co-ordination of odontogenesis and osteogenesis [25].
• Expression of the transcription factors Otlx2, Barx1 and Sox9 during mouse odontogenesis [26].

Analytical, diagnostic and therapeutic context of Odontogenesis

• We examine Osc expression by in situ hybridization during murine development, detailing temporospatial relationships with Msx2 expression during preappositional and appositional odontogenesis and calvarial osteogenesis [7].
• Developing teeth of 32 human fetuses (crown-rump length 11-205 mm) were examined immunohistochemically by antisera to protein gene product 9.5 (PGP 9.5) in an attempt to shed light upon the possible role of innervation in odontogenesis [27].

References