Chemical Compound Review:
AC1MHWLS (2S)-N-[(2S)-2-acetamido-4- methyl...
Synonyms:
CCRIS 3604, CHEBI:468978, LS-87930, Leupeptin (LEU), EINECS 259-242-2, ...
- Leupeptin, a protease inhibitor, decreases protein degradation in normal and diseased muscles. Libby, P., Goldberg, A.L. Science (1978)
- Effect of leupeptin, a protease inhibitor, on induction of bladder tumors in rats by n-butyl-n-(4-hydroxybutyl)nitrosamine. Kakizoe, T., Takayasu, H., Kawachi, T., Sugimura, T., Takeuchi, T. J. Natl. Cancer Inst. (1976)
- Protease inhibitors suppress the in vitro and in vivo replication of rotavirus. Vonderfecht, S.L., Miskuff, R.L., Wee, S.B., Sato, S., Tidwell, R.R., Geratz, J.D., Yolken, R.H. J. Clin. Invest. (1988)
- Inhibition of experimental blood-borne lung metastasis by protease inhibitors. Saito, D., Sawamura, M., Umezawa, K., Kanai, Y., Furihata, C., Matsushima, T., Sugimura, T. Cancer Res. (1980)
- Protease inhibitor coinfusion with amyloid beta-protein results in enhanced deposition and toxicity in rat brain. Frautschy, S.A., Horn, D.L., Sigel, J.J., Harris-White, M.E., Mendoza, J.J., Yang, F., Saido, T.C., Cole, G.M. J. Neurosci. (1998)
- Inhibitors of Ca(2+)-dependent endopeptidases modulate morphine-induced effects in rats. Lyupina, Y.V., Sudakov, S.K., Yarygin, V.N. Eur. J. Pharmacol. (1996)
- Purification of a trypsin-type protease from human umbilical vein endothelial cells which is highly sensitive to the Kunitz inhibitor domain peptide of Alzheimer's disease amyloid protein precursor. Kido, H., Takeda, M., Wakabayashi, H., Tanaka, S., Nishimura, N., Takenaka, M., Okada, M. Gerontology. (1993)
- HDL3-signalling in HepG2 cells involves glycosyl-phosphatidylinositol-anchored proteins. Nazih-Sanderson, F., Pinchon, G., Nion, S., Fruchart, J.C., Delbart, C. Biochim. Biophys. Acta (1997)
- Pharmacological dissociation of memory: anisomycin, a protein synthesis inhibitor, and leupeptin, a protease inhibitor, block different learning tasks. Stäubli, U., Faraday, R., Lynch, G. Behavioral and neural biology. (1985)
- Proteolytic processing activates a viral superantigen. Mix, D., Winslow, G.M. J. Exp. Med. (1996)
- Invariant chain cleavage and peptide loading in major histocompatibility complex class II vesicles. Amigorena, S., Webster, P., Drake, J., Newcomb, J., Cresswell, P., Mellman, I. J. Exp. Med. (1995)
- Generation of the neutrophil-activating peptide NAP-2 from platelet basic protein or connective tissue-activating peptide III through monocyte proteases. Walz, A., Baggiolini, M. J. Exp. Med. (1990)
- Time-dependent changes in protein kinase C distribution and disappearance in phorbol ester-treated human osteosarcoma cells. Krug, E., Tashjian, A.H. Cancer Res. (1987)
- Effects of the protease inhibitor leupeptin on proteolytic activities and regeneration of mouse skeletal muscles after exercise injuries. Salminen, A. Am. J. Pathol. (1984)
- Activation of human Glu-plasminogen to Glu-plasmin by urokinase in presence of plasmin inhibitors. Streptomyces leupeptin and human plasma alpha1-antitrypsin and antithrombin III (plus heparin). Summaria, L., Boreisha, I.G., Arzadon, L., Robbins, K.C. J. Biol. Chem. (1977)
- Role of cellular proteinases in acute myocardial infarction. I. Proteolysis in nonischemic and ischemic rat myocardium and the effects of antipain, leupeptin, pepstatin and chymostatin administered in vivo. Bolli, R., Cannon, R.O., Speir, E., Goldstein, R.E., Epstein, S.E. J. Am. Coll. Cardiol. (1983)
- Effects of heparin on osteoclast activity. Chowdhury, M.H., Hamada, C., Dempster, D.W. J. Bone Miner. Res. (1992)
- Mast cell tryptase stimulates the synthesis of type I collagen in human lung fibroblasts. Cairns, J.A., Walls, A.F. J. Clin. Invest. (1997)
- Intestinal epithelial cells use two distinct pathways for HLA class II antigen processing. Hershberg, R.M., Framson, P.E., Cho, D.H., Lee, L.Y., Kovats, S., Beitz, J., Blum, J.S., Nepom, G.T. J. Clin. Invest. (1997)
- Nonselective autophagy of cytosolic enzymes by isolated rat hepatocytes. Kopitz, J., Kisen, G.O., Gordon, P.B., Bohley, P., Seglen, P.O. J. Cell Biol. (1990)
- Transcriptional and post-transcriptional regulation of tyrosine hydroxylase gene by protein kinase C. Vyas, S., Faucon Biguet, N., Mallet, J. EMBO J. (1990)
- Inhibition of fusion of embryonic muscle cells in culture by tunicamycin is prevented by leupeptin. Olden, K., Law, J., Hunter, V.A., Romain, R., Parent, J.B. J. Cell Biol. (1981)
- Inhibition of autophagic-lysosomal delivery and autophagic lactolysis by asparagine. Høyvik, H., Gordon, P.B., Berg, T.O., Strømhaug, P.E., Seglen, P.O. J. Cell Biol. (1991)
- Ii chain controls the transport of major histocompatibility complex class II molecules to and from lysosomes. Brachet, V., Raposo, G., Amigorena, S., Mellman, I. J. Cell Biol. (1997)
- Receptor-mediated endocytosis of epidermal growth factor by rat hepatocytes: receptor pathway. Dunn, W.A., Connolly, T.P., Hubbard, A.L. J. Cell Biol. (1986)
- Cytochrome P-450 and NADPH-cytochrome P-450 reductase are degraded in the autolysosomes in rat liver. Masaki, R., Yamamoto, A., Tashiro, Y. J. Cell Biol. (1987)
- Exposure of K562 cells to anti-receptor monoclonal antibody OKT9 results in rapid redistribution and enhanced degradation of the transferrin receptor. Weissman, A.M., Klausner, R.D., Rao, K., Harford, J.B. J. Cell Biol. (1986)
- Further studies on the effect of leupeptin, a protease inhibitor, on induction of bladder tumors in rats by N-butyl-N-(4-hydroxybutyl)nitrosamine. Kakizoe, T., Esumi, H., Kawachi, T., Sugimura, T., Takeuchi, T., Umezawa, H. J. Natl. Cancer Inst. (1977)
- Proteinase activities of Entamoeba histolytica cytotoxin. Lushbaugh, W.B., Hofbauer, A.F., Pittman, F.E. Gastroenterology (1984)
- Adhesion of cells to polystyrene surfaces. Curtis, A.S., Forrester, J.V., McInnes, C., Lawrie, F. J. Cell Biol. (1983)
- Estrogen-induced membrane alterations and growth associated with proteinase activity in endometrial cells. Pietras, R.J., Szego, C.M. J. Cell Biol. (1979)
- Calpain-2 as a target for limiting prostate cancer invasion. Mamoune, A., Luo, J.H., Lauffenburger, D.A., Wells, A. Cancer Res. (2003)
- Saposin C is required for normal resistance of acid beta-glucosidase to proteolytic degradation. Sun, Y., Qi, X., Grabowski, G.A. J. Biol. Chem. (2003)
- Human airway trypsin-like protease increases mucin gene expression in airway epithelial cells. Chokki, M., Yamamura, S., Eguchi, H., Masegi, T., Horiuchi, H., Tanabe, H., Kamimura, T., Yasuoka, S. Am. J. Respir. Cell Mol. Biol. (2004)
- Clinical and laboratory studies of a new immunoradiometric assay of parathyroid hormone-related protein. Fraser, W.D., Robinson, J., Lawton, R., Durham, B., Gallacher, S.J., Boyle, I.T., Beastall, G.H., Logue, F.C. Clin. Chem. (1993)
- Differential DNA synthesis in response to activation of protease-activated receptors on cultured guinea-pig tracheal smooth muscle cells. Corteling, R., Bonneau, O., Ferretti, S., Ferretti, M., Trifilieff, A. Naunyn Schmiedebergs Arch. Pharmacol. (2003)
- Successful treatment of murine muscular dystrophy with the proteinase inhibitor leupeptin. Sher, J.H., Stracher, A., Shafiq, S.A., Hardy-Stashin, J. Proc. Natl. Acad. Sci. U.S.A. (1981)
- The CD8+ cell noncytotoxic anti-HIV response can be blocked by protease inhibitors. Mackewicz, C.E., Craik, C.S., Levy, J.A. Proc. Natl. Acad. Sci. U.S.A. (2003)
- Antipain and leupeptin restrict uterine DNA synthesis and function in mice. Katz, J., Troll, W., Adler, S.W., Levitz, M. Proc. Natl. Acad. Sci. U.S.A. (1977)