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Gene Review

SEMA6B  -  sema domain, transmembrane domain (TM),...

Homo sapiens

Synonyms: SEM-SEMA-Y, SEMA-VIB, SEMAN, SEMAZ, Sema Z, ...
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High impact information on SEMA6B

  • The cytoplasmic domain of Sema VIb contains several proline-rich potential SH3 domain binding sites [1].
  • We detected the semaZ mRNA in the first branchial arch of embryonic day 11 (E11) rat embryo, and subsequently in the myotomes and the dorsal root ganglia in developing somites from E11.5 through E13.5, but not in the brain [2].
  • We cloned a novel member (semaZ) of the semaphorin gene family from a rat brain cDNA library [2].
  • Lactate dehydrogenase isoenzyme patterns were obtained in the seman of 93 male partners of infertile couples and 28 proven fertile subjects as a control group [3].
  • The latter finding was in accordance with the low spermine levels in azo-ospermic semen, which were about 50% of those found in normospermic and oligospermic seman [4].


  1. A novel transmembrane semaphorin can bind c-src. Eckhardt, F., Behar, O., Calautti, E., Yonezawa, K., Nishimoto, I., Fishman, M.C. Mol. Cell. Neurosci. (1997) [Pubmed]
  2. Molecular cloning of a novel member of semaphorin family genes, semaphorin Z. Kikuchi, K., Ishida, H., Kimura, T. Brain Res. Mol. Brain Res. (1997) [Pubmed]
  3. Seminal LDH-C4 isoenzyme and sperm mitochondrial activity: a study in male partners of infertile couples. Sawane, M.V., Kaore, S.B., Gaikwad, R.D., Patil, P.M., Patankar, S.S., Deshkar, A.M. Indian journal of medical sciences. (2002) [Pubmed]
  4. Immunosuppressive activity and polyamine levels of seminal plasma in azo-ospermic, oligospermic, and normospermic men. Shohat, B., Maayan, R., Singer, R., Sagiv, M., Kaufman, H., Zukerman, Z. Arch. Androl. (1990) [Pubmed]
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