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Cdk20  -  cyclin-dependent kinase 20

Mus musculus

Synonyms: 4932702G04Rik, AU019450, AW558027, CAK-kinase p42, CDCH, ...
 
 
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Disease relevance of Ccrk

  • Antiplatelet activities of anthrax lethal toxin are associated with suppressed p42/44 and p38 mitogen-activated protein kinase pathways in the platelets [1].
  • A novel strain, Origami(DE3), of Escherichia coli with mutations in the glutathione and thioredoxin reductase genes yielded 60% more soluble PvMSP-1 p42 than the conventional E. coli BL21(DE3) strain [2].
 

High impact information on Ccrk

  • Differentiation induction and proliferation inhibition were required for optimal suppression of leukemogenesis, as indicated by the effects of p42 C/EBPalpha, which were more potent than those of K298E C/EBPalpha, a mutant defective in DNA binding and transcription activation that failed to induce granulocyte differentiation [3].
  • Phosphorylation of p42 and p44 MAP kinase (MAPK) was reduced approximately 32% [4].
  • PvMSP-1 p42 was found to have the predicted primary and tertiary structures and consisted of a single conformer containing one free cysteine, as predicted [2].
  • Preptin induced phosphorylation of p42/p44 MAP kinases in osteoblastic cells in a dose-dependent manner (10(-8)-10(-10) M), and its proliferative effects on primary osteoblasts were blocked by MAP kinase kinase inhibitors [5].
 

Associations of Ccrk with chemical compounds

  • Neuroprotection was associated with a smaller increase in [Ca2+]i in hypoxic neurons and required IP3 receptors and phospholipase C. In hypoxic neurons, isoflurane increased the phosphorylation of the Ca2+-dependent MAP kinases Pyk2 and p42/44 (ERK) [6].
 

Analytical, diagnostic and therapeutic context of Ccrk

  • Data from Western blot analysis indicated that LT treatment resulted in the suppression of p42/44 and p38 mitogen-activated protein kinase pathways in platelets [1].

References

  1. Antiplatelet activities of anthrax lethal toxin are associated with suppressed p42/44 and p38 mitogen-activated protein kinase pathways in the platelets. Kau, J.H., Sun, D.S., Tsai, W.J., Shyu, H.F., Huang, H.H., Lin, H.C., Chang, H.H. J. Infect. Dis. (2005) [Pubmed]
  2. Purification, characterization, and immunogenicity of a disulfide cross-linked Plasmodium vivax vaccine candidate antigen, merozoite surface protein 1, expressed in Escherichia coli. Dutta, S., Ware, L.A., Barbosa, A., Ockenhouse, C.F., Lanar, D.E. Infect. Immun. (2001) [Pubmed]
  3. Leukemogenesis induced by wild-type and STI571-resistant BCR/ABL is potently suppressed by C/EBPalpha. Ferrari-Amorotti, G., Keeshan, K., Zattoni, M., Guerzoni, C., Iotti, G., Cattelani, S., Donato, N.J., Calabretta, B. Blood (2006) [Pubmed]
  4. Overexpression of protein-tyrosine phosphatase-1B in adipocytes inhibits insulin-stimulated phosphoinositide 3-kinase activity without altering glucose transport or Akt/Protein kinase B activation. Venable, C.L., Frevert, E.U., Kim, Y.B., Fischer, B.M., Kamatkar, S., Neel, B.G., Kahn, B.B. J. Biol. Chem. (2000) [Pubmed]
  5. Preptin, another peptide product of the pancreatic beta-cell, is osteogenic in vitro and in vivo. Cornish, J., Callon, K.E., Bava, U., Watson, M., Xu, X., Lin, J.M., Chan, V.A., Grey, A.B., Naot, D., Buchanan, C.M., Cooper, G.J., Reid, I.R. Am. J. Physiol. Endocrinol. Metab. (2007) [Pubmed]
  6. The inhaled anesthetic, isoflurane, enhances Ca2+-dependent survival signaling in cortical neurons and modulates MAP kinases, apoptosis proteins and transcription factors during hypoxia. Bickler, P.E., Fahlman, C.S. Anesth. Analg. (2006) [Pubmed]
 
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