Gene Review:
Ptk2b - PTK2 protein tyrosine kinase 2 beta
Mus musculus
Synonyms:
CADTK, CAK-beta, CAKB, CAKbeta, Calcium-dependent tyrosine kinase, ...
- PYK2 in osteoclasts is an adhesion kinase, localized in the sealing zone, activated by ligation of alpha(v)beta3 integrin, and phosphorylated by src kinase. Duong, L.T., Lakkakorpi, P.T., Nakamura, I., Machwate, M., Nagy, R.M., Rodan, G.A. J. Clin. Invest. (1998)
- Oncoprotein Akt/PKB induces trophic effects in murine models of Parkinson's disease. Ries, V., Henchcliffe, C., Kareva, T., Rzhetskaya, M., Bland, R., During, M.J., Kholodilov, N., Burke, R.E. Proc. Natl. Acad. Sci. U.S.A. (2006)
- Inhibition of osteoclast function by adenovirus expressing antisense protein-tyrosine kinase 2. Duong, L.T., Nakamura, I., Lakkakorpi, P.T., Lipfert, L., Bett, A.J., Rodan, G.A. J. Biol. Chem. (2001)
- Defective proximal TCR signaling inhibits CD8+ tumor-infiltrating lymphocyte lytic function. Koneru, M., Schaer, D., Monu, N., Ayala, A., Frey, A.B. J. Immunol. (2005)
- Cas, Fak and Pyk2 function in diverse signaling cascades to promote Yersinia uptake. Bruce-Staskal, P.J., Weidow, C.L., Gibson, J.J., Bouton, A.H. J. Cell. Sci. (2002)
- Defective microtubule-dependent podosome organization in osteoclasts leads to increased bone density in Pyk2(-/-) mice. Gil-Henn, H., Destaing, O., Sims, N.A., Aoki, K., Alles, N., Neff, L., Sanjay, A., Bruzzaniti, A., De Camilli, P., Baron, R., Schlessinger, J. J. Cell Biol. (2007)
- Absence of marginal zone B cells in Pyk-2-deficient mice defines their role in the humoral response. Guinamard, R., Okigaki, M., Schlessinger, J., Ravetch, J.V. Nat. Immunol. (2000)
- The human and mouse complement of SH2 domain proteins-establishing the boundaries of phosphotyrosine signaling. Liu, B.A., Jablonowski, K., Raina, M., Arcé, M., Pawson, T., Nash, P.D. Mol. Cell (2006)
- Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway. Manning, B.D., Tee, A.R., Logsdon, M.N., Blenis, J., Cantley, L.C. Mol. Cell (2002)
- Role of PYK2 in the development of obesity and insulin resistance. Yu, Y., Ross, S.A., Halseth, A.E., Hollenbach, P.W., Hill, R.J., Gulve, E.A., Bond, B.R. Biochem. Biophys. Res. Commun. (2005)
- Induction of apoptosis after expression of PYK2, a tyrosine kinase structurally related to focal adhesion kinase. Xiong, W., Parsons, J.T. J. Cell Biol. (1997)
- Inhibition of PYK2-induced actin cytoskeleton reorganization, PYK2 autophosphorylation and focal adhesion targeting by FAK. Du, Q.S., Ren, X.R., Xie, Y., Wang, Q., Mei, L., Xiong, W.C. J. Cell. Sci. (2001)
- Integrin-mediated signal transduction in cells lacking focal adhesion kinase p125FAK. Ueki, K., Mimura, T., Nakamoto, T., Sasaki, T., Aizawa, S., Hirai, H., Yano, S., Naruse, T., Nojima, Y. FEBS Lett. (1998)
- PYK2 is an adhesion kinase in macrophages, localized in podosomes and activated by beta(2)-integrin ligation. Duong, L.T., Rodan, G.A. Cell Motil. Cytoskeleton (2000)
- The related adhesion focal tyrosine kinase forms a complex with paxillin in hematopoietic cells. Salgia, R., Avraham, S., Pisick, E., Li, J.L., Raja, S., Greenfield, E.A., Sattler, M., Avraham, H., Griffin, J.D. J. Biol. Chem. (1996)
- Mechanical strain on osteoblasts activates autophosphorylation of focal adhesion kinase and proline-rich tyrosine kinase 2 tyrosine sites involved in ERK activation. Boutahar, N., Guignandon, A., Vico, L., Lafage-Proust, M.H. J. Biol. Chem. (2004)
- Prolin-rich tyrosine kinase 2 (PYK2) expression and localization in mouse testis. Chieffi, P., Barchi, M., Di Agostino, S., Rossi, P., Tramontano, D., Geremia, R. Mol. Reprod. Dev. (2003)
- Mitogen-Activated Protein Kinases Inhibit the ROMK (Kir 1.1)-Like Small Conductance K Channels in the Cortical Collecting Duct. Babilonia, E., Li, D., Wang, Z., Sun, P., Lin, D.H., Jin, Y., Wang, W.H. J. Am. Soc. Nephrol. (2006)
- Calcineurin is essential for depolarization-induced nuclear translocation and tyrosine phosphorylation of PYK2 in neurons. Faure, C., Corvol, J.C., Toutant, M., Valjent, E., Hvalby, O., Jensen, V., El Messari, S., Corsi, J.M., Kadaré, G., Girault, J.A. J. Cell. Sci. (2007)
- Analysis of the calcium-dependent regulation of proline-rich tyrosine kinase 2 by gonadotropin-releasing hormone. Xie, J., Allen, K.H., Marguet, A., Berghorn, K.A., Bliss, S.P., Navratil, A.M., Guan, J.L., Roberson, M.S. Mol. Endocrinol. (2008)
- Src kinase activity is essential for osteoclast function. Miyazaki, T., Sanjay, A., Neff, L., Tanaka, S., Horne, W.C., Baron, R. J. Biol. Chem. (2004)
- Different modes and qualities of tyrosine phosphorylation of Fak and Pyk2 during epithelial-mesenchymal transdifferentiation and cell migration: analysis of specific phosphorylation events using site-directed antibodies. Nakamura, K., Yano, H., Schaefer, E., Sabe, H. Oncogene (2001)
- Induced focal adhesion kinase (FAK) expression in FAK-null cells enhances cell spreading and migration requiring both auto- and activation loop phosphorylation sites and inhibits adhesion-dependent tyrosine phosphorylation of Pyk2. Owen, J.D., Ruest, P.J., Fry, D.W., Hanks, S.K. Mol. Cell. Biol. (1999)
- Cooperative inhibition of T-cell antigen receptor signaling by a complex between a kinase and a phosphatase. Cloutier, J.F., Veillette, A. J. Exp. Med. (1999)
- Osmotic shock stimulates GLUT4 translocation in 3T3L1 adipocytes by a novel tyrosine kinase pathway. Chen, D., Elmendorf, J.S., Olson, A.L., Li, X., Earp, H.S., Pessin, J.E. J. Biol. Chem. (1997)
- Inhibition of SRC tyrosine kinases suppresses activation of nuclear factor-kappaB, and serine and tyrosine phosphorylation of IkappaB-alpha in lipopolysaccharide-stimulated raw 264.7 macrophages. Kang, J.L., Lee, H.W., Kim, H.J., Lee, H.S., Castranova, V., Lim, C.M., Koh, Y. J. Toxicol. Environ. Health Part A (2005)
- Stable association of PYK2 and p130(Cas) in osteoclasts and their co-localization in the sealing zone. Lakkakorpi, P.T., Nakamura, I., Nagy, R.M., Parsons, J.T., Rodan, G.A., Duong, L.T. J. Biol. Chem. (1999)
- In vivo and in vitro specificity of protein tyrosine kinases for immunoglobulin G receptor (FcgammaRII) phosphorylation. Bewarder, N., Weinrich, V., Budde, P., Hartmann, D., Flaswinkel, H., Reth, M., Frey, J. Mol. Cell. Biol. (1996)
- Developmental abnormalities of myelin basic protein expression in fyn knock-out brain reveal a role of Fyn in posttranscriptional regulation. Lu, Z., Ku, L., Chen, Y., Feng, Y. J. Biol. Chem. (2005)
- Evidence for protein tyrosine kinase involvement in ligand-induced TCR/CD3 internalization and surface redistribution. Luton, F., Buferne, M., Davoust, J., Schmitt-Verhulst, A.M., Boyer, C. J. Immunol. (1994)
- Expression and characterization of splice variants of PYK2, a focal adhesion kinase-related protein. Xiong, W.C., Macklem, M., Parsons, J.T. J. Cell. Sci. (1998)
- Regulation of Src-family protein tyrosine kinase transcription during lymphocyte ontogeny. Longo, N.S., Wang, X., Wildin, R.S., Abraham, K.M. Mol. Immunol. (1999)