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Gene Review

CDK20  -  cyclin-dependent kinase 20

Homo sapiens

Synonyms: CAK-kinase p42, CCRK, CDCH, CDK-activating kinase p42, Cell cycle-related kinase, ...
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Disease relevance of CCRK


Psychiatry related information on CCRK

  • Dose- and time-response relations for the DBH and the CDCH are very similar [6].

High impact information on CCRK


Chemical compound and disease context of CCRK


Biological context of CCRK


Anatomical context of CCRK


Associations of CCRK with chemical compounds

  • Because p42/44 MAPK mediates the effect of PGE2 on protein synthesis, we also examined the role of MAPKs in the regulation of BNP promoter activity [24].
  • Purified p42 phosphorylated glutathione S-transferase-CDK2 at Thr-160 within the T-loop and activated its histone H1 kinase activity [19].
  • In a previous study, we demonstrated that sodium salicylate (NaSal) selectively inhibits tumor necrosis factor (TNF)-induced activation of the p42 and p44 mitogen-activated protein kinases (MAPKs) (known as extracellular signal-regulated kinases) [25].
  • Also, in AGER1 cells, AGE-induced H(2)O(2) formation and AGE- or S100-induced p44/p42 phosphorylation were suppressed, and these effects were restored by R1 siRNA [26].
  • Granulocyte-macrophage colony-stimulating factor, interleukin-3, and steel factor induce rapid tyrosine phosphorylation of p42 and p44 MAP kinase [27].

Regulatory relationships of CCRK


Other interactions of CCRK

  • CXCL11 significantly increased BrdU incorporation of ESC, which was inhibited by a p42/44 MAPK pathway inhibitor PD98059 [32].
  • PGE2 stimulation of the hBNP promoter was inhibited by a MEK1/2 inhibitor and a dominant-negative mutant of Raf, indicating that p42/44 MAPK was involved [24].
  • CONCLUSION: These results suggest that SPC-induced IL-6 production is mediated by PKC-dependent p42/44 ERK activation in human dermal fibroblasts cultured in vitro [22].
  • Although PNQALRE/CCRK was recently proposed to activate Cdk2, we show that the monomeric protein has no intrinsic CAK activity [33].
  • p42, a novel cyclin-dependent kinase-activating kinase in mammalian cells [19].

Analytical, diagnostic and therapeutic context of CCRK


  1. Effect of lipid rafts on cb2 receptor signaling and 2-arachidonoyl-glycerol metabolism in human immune cells. Bari, M., Spagnuolo, P., Fezza, F., Oddi, S., Pasquariello, N., Finazzi-Agr??, A., Maccarrone, M. J. Immunol. (2006) [Pubmed]
  2. Overexpression of midkine contributes to anti-apoptotic effects in human meningiomas. Tong, Y., Mentlein, R., Buhl, R., Hugo, H.H., Krause, J., Mehdorn, H.M., Held-Feindt, J. J. Neurochem. (2007) [Pubmed]
  3. Acute hyperglycemia causes intracellular formation of CML and activation of ras, p42/44 MAPK, and nuclear factor kappaB in PBMCs. Schiekofer, S., Andrassy, M., Chen, J., Rudofsky, G., Schneider, J., Wendt, T., Stefan, N., Humpert, P., Fritsche, A., Stumvoll, M., Schleicher, E., Häring, H.U., Nawroth, P.P., Bierhaus, A. Diabetes (2003) [Pubmed]
  4. Activation of mitogen-activated protein kinases p42/44, p38, and stress-activated protein kinases in myelo-monocytic cells by Treponema lipoteichoic acid. Schröder, N.W., Pfeil, D., Opitz, B., Michelsen, K.S., Amberger, J., Zähringer, U., Göbel, U.B., Schumann, R.R. J. Biol. Chem. (2001) [Pubmed]
  5. Expression and activity of mitogen activated protein kinases in human colorectal carcinoma. Eggstein, S., Franke, M., Kutschka, I., Manthey, G., von Specht, B.U., Ruf, G., Farthmann, E.H. Gut (1999) [Pubmed]
  6. Effects of two gonadotropic hormones on polysaccharide synthesis in the albumen gland of Lymnaea stagnalis, studied with the organ culture technique. Wijdenes, J., van Elk, R., Joosse, J. Gen. Comp. Endocrinol. (1983) [Pubmed]
  7. Interleukin-1 activates a novel protein kinase cascade that results in the phosphorylation of Hsp27. Freshney, N.W., Rawlinson, L., Guesdon, F., Jones, E., Cowley, S., Hsuan, J., Saklatvala, J. Cell (1994) [Pubmed]
  8. Antigens encoded by the 3'-terminal region of human T-cell leukemia virus: evidence for a functional gene. Lee, T.H., Coligan, J.E., Sodroski, J.G., Haseltine, W.A., Salahuddin, S.Z., Wong-Staal, F., Gallo, R.C., Essex, M. Science (1984) [Pubmed]
  9. Sphingosylphosphorylcholine is a ligand for ovarian cancer G-protein-coupled receptor 1. Xu, Y., Zhu, K., Hong, G., Wu, W., Baudhuin, L.M., Xiao, Y., Damron, D.S. Nat. Cell Biol. (2000) [Pubmed]
  10. Isolated lymphatic endothelial cells transduce growth, survival and migratory signals via the VEGF-C/D receptor VEGFR-3. Mäkinen, T., Veikkola, T., Mustjoki, S., Karpanen, T., Catimel, B., Nice, E.C., Wise, L., Mercer, A., Kowalski, H., Kerjaschki, D., Stacker, S.A., Achen, M.G., Alitalo, K. EMBO J. (2001) [Pubmed]
  11. MIP-3alpha induces human eosinophil migration and activation of the mitogen-activated protein kinases (p42/p44 MAPK). Sullivan, S.K., McGrath, D.A., Liao, F., Boehme, S.A., Farber, J.M., Bacon, K.B. J. Leukoc. Biol. (1999) [Pubmed]
  12. The mitogen-activated protein kinase pathway contributes to vanadate toxicity in vascular smooth muscle cells. Daum, G., Levkau, B., Chamberlain, N.L., Wang, Y., Clowes, A.W. Mol. Cell. Biochem. (1998) [Pubmed]
  13. P38 MAPK, but not p42/p44 MAPK mediated inducible nitric oxide synthase expression in C6 glioma cells. Xu, X., Malave, A. Life Sci. (2000) [Pubmed]
  14. Activation of protein serine/threonine kinases p42, p63, and p87 in Rous sarcoma virus-transformed cells: signal transduction/transformation-dependent MBP kinases. Wang, H.C., Erikson, R.L. Mol. Biol. Cell (1992) [Pubmed]
  15. Induction of connective tissue growth factor by activation of heptahelical receptors. Modulation by Rho proteins and the actin cytoskeleton. Hahn, A., Heusinger-Ribeiro, J., Lanz, T., Zenkel, S., Goppelt-Struebe, M. J. Biol. Chem. (2000) [Pubmed]
  16. Identification of Yin-Yang Regulators and a Phosphorylation Consensus for Male Germ Cell-Associated Kinase (MAK)-Related Kinase. Fu, Z., Larson, K.A., Chitta, R.K., Parker, S.A., Turk, B.E., Lawrence, M.W., Kaldis, P., Galaktionov, K., Cohn, S.M., Shabanowitz, J., Hunt, D.F., Sturgill, T.W. Mol. Cell. Biol. (2006) [Pubmed]
  17. Role of caveolin-1 in p42/p44 MAP kinase activation and proliferation of human airway smooth muscle. Gosens, R., Stelmack, G.L., Dueck, G., McNeill, K.D., Yamasaki, A., Gerthoffer, W.T., Unruh, H., Gounni, A.S., Zaagsma, J., Halayko, A.J. Am. J. Physiol. Lung Cell Mol. Physiol. (2006) [Pubmed]
  18. Abnormal insulin-like growth factor 1 signaling in human osteoarthritic subchondral bone osteoblasts. Massicotte, F., Aubry, I., Martel-Pelletier, J., Pelletier, J.P., Fernandes, J., Lajeunesse, D. Arthritis Res. Ther. (2006) [Pubmed]
  19. p42, a novel cyclin-dependent kinase-activating kinase in mammalian cells. Liu, Y., Wu, C., Galaktionov, K. J. Biol. Chem. (2004) [Pubmed]
  20. Requirement for p38 and p44/p42 mitogen-activated protein kinases in RAGE-mediated nuclear factor-kappaB transcriptional activation and cytokine secretion. Yeh, C.H., Sturgis, L., Haidacher, J., Zhang, X.N., Sherwood, S.J., Bjercke, R.J., Juhasz, O., Crow, M.T., Tilton, R.G., Denner, L. Diabetes (2001) [Pubmed]
  21. Legionella pneumophila-induced PKC{alpha}-, MAPK-, and NF-{kappa}B-dependent COX-2 expression in human lung epithelium. N'guessan, P.D., Etouem, M.O., Schmeck, B., Hocke, A.C., Scharf, S., Vardarova, K., Opitz, B., Flieger, A., Suttorp, N., Hippenstiel, S. Am. J. Physiol. Lung Cell Mol. Physiol. (2007) [Pubmed]
  22. Sphingosylphosphorylcholine-induced interleukin-6 production is mediated by protein kinase C and p42/44 extracellular signal-regulated kinase in human dermal fibroblasts. Kwon, Y.B., Lee, Y.S., Sohn, K.C., Piao, Y.J., Back, S.J., Seo, Y.J., Suhr, K.B., Park, J.K., Kim, C.D., Lee, J.H. J. Dermatol. Sci. (2007) [Pubmed]
  23. Light stimulates MSK1 activation in the suprachiasmatic nucleus via a PACAP-ERK/MAP kinase-dependent mechanism. Butcher, G.Q., Lee, B., Cheng, H.Y., Obrietan, K. J. Neurosci. (2005) [Pubmed]
  24. PGE2 stimulates human brain natriuretic peptide expression via EP4 and p42/44 MAPK. Qian, J.Y., Leung, A., Harding, P., LaPointe, M.C. Am. J. Physiol. Heart Circ. Physiol. (2006) [Pubmed]
  25. Sodium salicylate induces apoptosis via p38 mitogen-activated protein kinase but inhibits tumor necrosis factor-induced c-Jun N-terminal kinase/stress-activated protein kinase activation. Schwenger, P., Bellosta, P., Vietor, I., Basilico, C., Skolnik, E.Y., Vilcek, J. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  26. Advanced glycation end product (AGE) receptor 1 suppresses cell oxidant stress and activation signaling via EGF receptor. Cai, W., He, J.C., Zhu, L., Lu, C., Vlassara, H. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  27. Granulocyte-macrophage colony-stimulating factor, interleukin-3, and steel factor induce rapid tyrosine phosphorylation of p42 and p44 MAP kinase. Okuda, K., Sanghera, J.S., Pelech, S.L., Kanakura, Y., Hallek, M., Griffin, J.D., Druker, B.J. Blood (1992) [Pubmed]
  28. Effects of {alpha}1D-adrenergic receptors on shedding of biologically active EGF in freshly isolated lacrimal gland epithelial cells. Chen, L., Hodges, R.R., Funaki, C., Zoukhri, D., Gaivin, R.J., Perez, D.M., Dartt, D.A. Am. J. Physiol., Cell Physiol. (2006) [Pubmed]
  29. Involvement of p42/44 MAPK in the effects of ethanol on secretion of insulin-like growth factor (IGF)-I and insulin-like growth factor binding protein (IGFBP)-1 in primary cultured rat hepatocytes. Lee, S.M., Alam, R., Ho, C.J., Kim, J.H., Kang, C.W., Park, J.H., Lee, M.S. Int. J. Neurosci. (2007) [Pubmed]
  30. Leptin signaling in human peripheral blood mononuclear cells, activation of p38 and p42/44 mitogen-activated protein (MAP) kinase and p70 S6 kinase. van den Brink, G.R., O'Toole, T., Hardwick, J.C., van den Boogaardt, D.E., Versteeg, H.H., van Deventer, S.J., Peppelenbosch, M.P. Mol. Cell Biol. Res. Commun. (2000) [Pubmed]
  31. Statin attenuates high glucose-induced and angiotensin II-induced MAP kinase activity through inhibition of NAD(P)H oxidase activity in cultured mesangial cells. Yu, H.Y., Inoguchi, T., Nakayama, M., Tsubouchi, H., Sato, N., Sonoda, N., Sasaki, S., Kobayashi, K., Nawata, H. Medicinal chemistry (Sh⁻ariqah, United Arab Emirates) (2005) [Pubmed]
  32. The Expression and Possible Roles of Chemokine CXCL11 and Its Receptor CXCR3 in the Human Endometrium. Hirota, Y., Osuga, Y., Koga, K., Yoshino, O., Hirata, T., Morimoto, C., Harada, M., Takemura, Y., Nose, E., Yano, T., Tsutsumi, O., Taketani, Y. J. Immunol. (2006) [Pubmed]
  33. The cyclin-dependent kinase (CDK) family member PNQALRE/CCRK supports cell proliferation but has no intrinsic CDK-activating kinase (CAK) activity. Wohlbold, L., Larochelle, S., Liao, J.C., Livshits, G., Singer, J., Shokat, K.M., Fisher, R.P. Cell Cycle (2006) [Pubmed]
  34. Regulation of mitogen-activated protein kinase in the pars tuberalis of the ovine pituitary: interactions between melatonin, insulin-like growth factor-1, and forskolin. Hazlerigg, D.G., Thompson, M., Hastings, M.H., Morgan, P.J. Endocrinology (1996) [Pubmed]
  35. Reperfusion injury revisited: is there a role for growth factor signaling in limiting lethal reperfusion injury? Yellon, D.M., Baxter, G.F. Trends Cardiovasc. Med. (1999) [Pubmed]
  36. Stimulation of Na+/H+ antiport and pyruvate kinase activities by high glucose concentration in human erythrocytes. Kaloyianni, M., Tsagias, N., Liakos, P., Zolota, Z., Christophorides, E., Koliakos, G.G. Mol. Cells (2004) [Pubmed]
  37. Isolation, characterization, and evolutionary aspects of a cDNA clone encoding multiple neuropeptides involved in the stereotyped egg-laying behavior of the freshwater snail Lymnaea stagnalis. Vreugdenhil, E., Jackson, J.F., Bouwmeester, T., Smit, A.B., Van Minnen, J., Van Heerikhuizen, H., Klootwijk, J., Joosse, J. J. Neurosci. (1988) [Pubmed]
  38. A variant form of ETS1 induces apoptosis in human colon cancer cells. Huang, C.C., Papas, T.S., Bhat, N.K. Oncogene (1997) [Pubmed]
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