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Gene Review

Scrib  -  scribbled homolog (Drosophila)

Mus musculus

Synonyms: AI118201, CRIB, Crc, Kiaa0147, Lap4, ...
 
 
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Disease relevance of Scrib

 

High impact information on Scrib

  • Polarization defects in animals heterozygous for Vangl2 and Scrb1 are comparable with Vangl2 homozygotes, demonstrating genetic interactions between these genes in the regulation of PCP in mammals [2].
  • We report the expression pattern of Scrb1 during embryonic and fetal development, and show that Scrb1 expression closely mirrors the phenotypic defects observed in Crc/Crc mutants [1].
  • This gene, Scrb1, encodes a member of the LAP protein family related to Drosophila scribble, with 16 leucine rich repeats and four PDZ domains [1].
  • (S)-alpha-methyl-3-carboxyphenylalanine, which is a potent and selective antagonist for LAP4 in the cortex, is anticonvulsant in DBA/2 mice and decreases the convulsant effect of N-methyl-D-aspartate, 3,5-dihydroxyphenylglycine, LAP4 and MPPG in Swiss-Webster mice [3].
  • With this method a low level of spontaneous humoral immunity was demonstrated in sera from AKR/Crc mice, a strain with high concentrations of endogenous virus, whereas little or no anti-viral activity was found inCBA/H-T6Crc, a subline that does not appear to express MuLV [4].
 

Biological context of Scrib

 

Other interactions of Scrib

  • Identification of Vangl2 and Scrb1 as planar polarity genes in mammals [2].

References

  1. Disruption of scribble (Scrb1) causes severe neural tube defects in the circletail mouse. Murdoch, J.N., Henderson, D.J., Doudney, K., Gaston-Massuet, C., Phillips, H.M., Paternotte, C., Arkell, R., Stanier, P., Copp, A.J. Hum. Mol. Genet. (2003) [Pubmed]
  2. Identification of Vangl2 and Scrb1 as planar polarity genes in mammals. Montcouquiol, M., Rachel, R.A., Lanford, P.J., Copeland, N.G., Jenkins, N.A., Kelley, M.W. Nature (2003) [Pubmed]
  3. Convulsant and anticonvulsant actions of agonists and antagonists of group III mGluRs. Ghauri, M., Chapman, A.G., Meldrum, B.S. Neuroreport (1996) [Pubmed]
  4. The use of 125I-labelled protein A for the detection of humoral immunity to gross murine leukaemia virus. Holmes, H.C., Tuffrey, M., Steuden, J., Hilgers, J., Barnes, R.D. J. Immunol. Methods (1980) [Pubmed]
  5. Epithelial cell polarity genes are required for neural tube closure. Doudney, K., Stanier, P. American journal of medical genetics. Part C, Seminars in medical genetics. (2005) [Pubmed]
 
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