Gene Review:
SCRIB - scribbled planar cell polarity protein
Homo sapiens
Synonyms:
CRIB1, KIAA0147, LAP4, Protein LAP4, Protein scribble homolog, ...
- The hScrib/Dlg apico-basal control complex is differentially targeted by HPV-16 and HPV-18 E6 proteins. Thomas, M., Massimi, P., Navarro, C., Borg, J.P., Banks, L. Oncogene (2005)
- The PDZ domain-binding motif of the human T cell leukemia virus type 1 tax protein induces mislocalization of the tumor suppressor hScrib in T cells. Arpin-André, C., Mesnard, J.M. J. Biol. Chem. (2007)
- Maintenance and modulation of T cell polarity. Krummel, M.F., Macara, I. Nat. Immunol. (2006)
- Thyrotropin receptor trafficking relies on the hScrib-betaPIX-GIT1-ARF6 pathway. Lahuna, O., Quellari, M., Achard, C., Nola, S., Méduri, G., Navarro, C., Vitale, N., Borg, J.P., Misrahi, M. EMBO J. (2005)
- The mammalian Scribble polarity protein regulates epithelial cell adhesion and migration through E-cadherin. Qin, Y., Capaldo, C., Gumbiner, B.M., Macara, I.G. J. Cell Biol. (2005)
- Human scribble (Vartul) is targeted for ubiquitin-mediated degradation by the high-risk papillomavirus E6 proteins and the E6AP ubiquitin-protein ligase. Nakagawa, S., Huibregtse, J.M. Mol. Cell. Biol. (2000)
- The tumor suppressor Scrib interacts with the zyxin-related protein LPP, which shuttles between cell adhesion sites and the nucleus. Petit, M.M., Meulemans, S.M., Alen, P., Ayoubi, T.A., Jansen, E., Van de Ven, W.J. BMC Cell Biol. (2005)
- Junctional recruitment of mammalian Scribble relies on E-cadherin engagement. Navarro, C., Nola, S., Audebert, S., Santoni, M.J., Arsanto, J.P., Ginestier, C., Marchetto, S., Jacquemier, J., Isnardon, D., Le Bivic, A., Birnbaum, D., Borg, J.P. Oncogene (2005)
- Human discs large and scrib are localized at the same regions in colon mucosa and changes in their expression patterns are correlated with loss of tissue architecture during malignant progression. Gardiol, D., Zacchi, A., Petrera, F., Stanta, G., Banks, L. Int. J. Cancer (2006)
- Scrib Controls Cdc42 Localization and Activity to Promote Cell Polarization during Astrocyte Migration. Osmani, N., Vitale, N., Borg, J.P., Etienne-Manneville, S. Curr. Biol. (2006)
- hScrib interacts with ZO-2 at the cell-cell junctions of epithelial cells. Métais, J.Y., Navarro, C., Santoni, M.J., Audebert, S., Borg, J.P. FEBS Lett. (2005)
- Groups II and III metabotropic glutamate receptors differentially modulate brief and prolonged nociception in primate STT cells. Neugebauer, V., Chen, P.S., Willis, W.D. J. Neurophysiol. (2000)
- Affinity modification of EcoRII DNA methyltransferase by the dialdehyde-substituted DNA duplexes: mapping the enzyme region that interacts with DNA. Gritsenko, O.M., Koudan, E.V., Mikhailov, S.N., Ermolinsky, B.S., Van Aerschot, A., Herdewijn, P., Gromova, E.S. Nucleosides Nucleotides Nucleic Acids (2002)
- The tumor suppressor Scrib selectively interacts with specific members of the zyxin family of proteins. Petit, M.M., Crombez, K.R., Vervenne, H.B., Weyns, N., Van de Ven, W.J. FEBS Lett. (2005)
- Human homolog of Drosophila tumor suppressor Scribble negatively regulates cell-cycle progression from G1 to S phase by localizing at the basolateral membrane in epithelial cells. Nagasaka, K., Nakagawa, S., Yano, T., Takizawa, S., Matsumoto, Y., Tsuruga, T., Nakagawa, K., Minaguchi, T., Oda, K., Hiraike-Wada, O., Ooishi, H., Yasugi, T., Taketani, Y. Cancer Sci. (2006)
- Human papillomavirus type 16 E6 protein interacts with cystic fibrosis transmembrane regulator-associated ligand and promotes E6-associated protein-mediated ubiquitination and proteasomal degradation. Jeong, K.W., Kim, H.Z., Kim, S., Kim, Y.S., Choe, J. Oncogene (2007)
- Basolateral targeting by leucine-rich repeat domains in epithelial cells. Legouis, R., Jaulin-Bastard, F., Schott, S., Navarro, C., Borg, J.P., Labouesse, M. EMBO Rep. (2003)
- Analysis of the expression and localisation of a LAP protein, human scribble, in the normal and neoplastic epithelium of uterine cervix. Nakagawa, S., Yano, T., Nakagawa, K., Takizawa, S., Suzuki, Y., Yasugi, T., Huibregtse, J.M., Taketani, Y. Br. J. Cancer (2004)
- Mammalian Scribble forms a tight complex with the betaPIX exchange factor. Audebert, S., Navarro, C., Nourry, C., Chasserot-Golaz, S., Lécine, P., Bellaiche, Y., Dupont, J.L., Premont, R.T., Sempéré, C., Strub, J.M., Van Dorsselaer, A., Vitale, N., Borg, J.P. Curr. Biol. (2004)