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Gene Review

lp_0041  -  Zn-dependent hydrolase, beta-lactamase...

Lactobacillus plantarum WCFS1

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Disease relevance of lp_0041

  • Cloning and expression of a conjugated bile acid hydrolase gene from Lactobacillus plantarum by using a direct plate assay [1].
  • For the screening of this hydrolase gene within the gene bank, a direct plate assay developed by Dashkevicz and Feighner (M. P. Dashkevicz and S. D. Feighner, Appl. Environ. Microbiol. 53:331-336, 1989) was adapted to the growth requirements of E. coli [1].
  • Cloning and characterization of a conjugated bile acid hydrolase gene from Clostridium perfringens [2].
  • The observed defects in the separation process, cell envelope perforation, and autolysis of the dlt mutant could be partially attributed to the L. plantarum Acm2 peptidoglycan hydrolase [3].

High impact information on lp_0041

  • Since L. plantarum, particularly strain WCFS1, is known to encode bile salt hydrolase (deconjugation) activity, our data indicate that mainly cholic acid, but not taurocholic acid, effectively permeabilizes the membrane to aminoglycosides [4].
  • Because of hydrolysis and medium acidification, hydrolase-active colonies were surrounded with big halos of precipitated, free bile acids [1].
  • Preliminary characterization of the gene product showed that it is a cholylglycine hydrolase (EC with only slight activity against taurine conjugates [1].
  • 5. Optimum temperature ranged from 30 to 45 degrees C. Southern blot analysis indicated that the cloned gene has similarity with genomic DNA of bile acid hydrolase-active Lactobacillus spp. of intestinal origin [1].
  • The bacterium Lactobacillus plantarum PH04 was isolated from infant feces and tested positive for bile/acid tolerance and bile salt hydrolase activity [5].


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