Chemical Compound Review:
AC1LCUMK (4S)-4-[ (3S,5R,7S,8S,9S,10S,12S,13R,14 S...
Synonyms:
cholan-24-oic acid, 3,7,12-trihydroxy-
- Validity and sensitivity of an intravenous bile acid tolerance test in patients with liver disease. LaRusso, N.F., Hoffman, N.E., Hofmann, A.F., Korman, M.G. N. Engl. J. Med. (1975)
- Chenotherapy for gallstone dissolution. II. Induced changes in bile composition and gallstone response. Hofmann, A.F., Thistle, J.L., Klein, P.D., Szczepanik, P.A., Yu, P.Y. JAMA (1978)
- The metabolism of 3alpha, 7alpha, 12alpha-trihydorxy-5beta-cholestan-26-oic acid in two siblings with cholestasis due to intrahepatic bile duct anomalies. An apparent inborn error of cholic acid synthesis. Hanson, R.F., Isenberg, J.N., Williams, G.C., Hachey, D., Szczepanik, P., Klein, P.D., Sharp, H.L. J. Clin. Invest. (1975)
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- Complex genetic control of HDL levels in mice in response to an atherogenic diet. Coordinate regulation of HDL levels and bile acid metabolism. Machleder, D., Ivandic, B., Welch, C., Castellani, L., Reue, K., Lusis, A.J. J. Clin. Invest. (1997)
- Profile of urinary bile acids in infants and children: developmental pattern of excretion of unsaturated ketonic bile acids and 7beta-hydroxylated bile acids. Kimura, A., Mahara, R., Inoue, T., Nomura, Y., Murai, T., Kurosawa, T., Tohma, M., Noguchi, K., Hoshiyama, A., Fujisawa, T., Kato, H. Pediatr. Res. (1999)
- Physical and chemical properties of DMP 504, a polyalkylammonium-based bile acid sequestrant. Raghavan, K.S., Chang, R.K., Pang, J., Figuly, G.D., Hussain, M.A. Pharmaceutical development and technology. (1997)
- Defects of bile acid synthesis in Zellweger's syndrome. Hanson, R.F., Szczepanik-VanLeeuwen, P., Williams, G.C., Grabowski, G., Sharp, H.L. Science (1979)
- 3 alpha-hydroxysteroid dehydrogenase activity of the Y' bile acid binders in rat liver cytosol. Identification, kinetics, and physiologic significance. Stolz, A., Takikawa, H., Sugiyama, Y., Kuhlenkamp, J., Kaplowitz, N. J. Clin. Invest. (1987)
- Defective peroxisomal cleavage of the C27-steroid side chain in the cerebro-hepato-renal syndrome of Zellweger. Kase, B.F., Björkhem, I., Hågå, P., Pedersen, J.I. J. Clin. Invest. (1985)
- Acute effects of dietary cholic acid and methylazoxymethanol acetate on colon epithelial cell proliferation; metabolism of bile salts and neutral sterols in conventional and germfree SD rats. Weidema, W.F., Deschner, E.E., Cohen, B.I., DeCosse, J.J. J. Natl. Cancer Inst. (1985)
- Biosynthesis of bile acids in cerebrotendinous xanthomatosis. Relationship of bile acid pool sizes and synthesis rates to hydroxylations at C-12, C-25, and C-26. Salen, G., Shefer, S., Tint, G.S., Nicolau, G., Dayal, B., Batta, A.K. J. Clin. Invest. (1985)
- Mechanism of cholic acid protection in lithocholate-induced intrahepatic cholestasis in rats. Kakis, G., Yousef, I.M. Gastroenterology (1980)
- Endogenous ursodeoxycholic acid and cholic acid in liver disease due to cystic fibrosis. Smith, J.L., Lewindon, P.J., Hoskins, A.C., Pereira, T.N., Setchell, K.D., O'Connell, N.C., Shepherd, R.W., Ramm, G.A. Hepatology (2004)
- Normal fasting-state levels of serum cholyl-conjugated bile acids in Gilbert's syndrome: an aid to the diagnosis. Vierling, J.M., Berk, P.D., Hofmann, A.F., Martin, J.F., Wolkoff, A.W., Scharschmidt, B.F. Hepatology (1982)
- Cholic acid synthesis from 26-hydroxycholesterol and 3-hydroxy-5-cholestenoic acid in the rabbit. Ayaki, Y., Kok, E., Javitt, N.B. J. Biol. Chem. (1989)
- Identification and characterization of a bile acid receptor in isolated liver surface membranes. Accatino, L., Simon, F.R. J. Clin. Invest. (1976)
- Description and simulation of a physiological pharmacokinetic model for the metabolism and enterohepatic circulation of bile acids in man. Cholic acid in healthy man. Hofmann, A.F., Molino, G., Milanese, M., Belforte, G. J. Clin. Invest. (1983)
- A 25-hydroxylation pathway of cholic acid biosynthesis in man and rat. Shefer, S., Cheng, F.W., Dayal, B., Hauser, S., Tint, G.S., Salen, G., Mosbach, E.H. J. Clin. Invest. (1976)
- Bile acid conjugation in organ culture of human fetal liver. Haber, L.R., Vaupshas, V., Vitullo, B.B., Seemayer, T.A., de Belle, R.C. Gastroenterology (1978)
- Pancreatic carboxypeptidase hydrolysis of bile acid-amino conjugates: selective resistance of glycine and taurine amidates. Huijghebaert, S.M., Hofmann, A.F. Gastroenterology (1986)
- Gallstone dissolution in man using cholic acid and lecithin. Toouli, J., Jablonski, P., Watts, J.M. Lancet (1975)
- Induction of sodium-dependent bile acid transporter messenger RNA, protein, and activity in rat ileum by cholic acid. Stravitz, R.T., Sanyal, A.J., Pandak, W.M., Vlahcevic, Z.R., Beets, J.W., Dawson, P.A. Gastroenterology (1997)
- Bile acid-induced inhibition of the lymphoproliferative response to phytohemagglutinin and pokeweed mitogen: an in vitro study. Gianni, L., Di Padova, F., Zuin, M., Podda, M. Gastroenterology (1980)
- Measurement in vivo of proliferation rates of slow turnover cells by 2H2O labeling of the deoxyribose moiety of DNA. Neese, R.A., Misell, L.M., Turner, S., Chu, A., Kim, J., Cesar, D., Hoh, R., Antelo, F., Strawford, A., McCune, J.M., Christiansen, M., Hellerstein, M.K. Proc. Natl. Acad. Sci. U.S.A. (2002)
- Massive xanthomatosis and atherosclerosis in cholesterol-fed low density lipoprotein receptor-negative mice. Ishibashi, S., Goldstein, J.L., Brown, M.S., Herz, J., Burns, D.K. J. Clin. Invest. (1994)
- Pathogenic factors in early recurrence of cholesterol gallstones. Berr, F., Mayer, M., Sackmann, M.F., Sauerbruch, T., Holl, J., Paumgartner, G. Gastroenterology (1994)
- Benign recurrent intrahepatic cholestasis: altered bile acid metabolism. Bijleveld, C.M., Vonk, R.J., Kuipers, F., Havinga, R., Boverhof, R., Koopman, B.J., Wolthers, B.G., Fernandes, J. Gastroenterology (1989)
- Pool size, synthesis, and turnover of sulfated and nonsulfated cholic acid and chenodeoxycholic acid in patients with cirrhosis of the liver. Stiehl, A., Ast, E., Czygan, P., Fröhling, W., Raedsch, R., Kommerell, B. Gastroenterology (1978)
- Identification of bile acid precursors as endogenous ligands for the nuclear xenobiotic pregnane X receptor. Goodwin, B., Gauthier, K.C., Umetani, M., Watson, M.A., Lochansky, M.I., Collins, J.L., Leitersdorf, E., Mangelsdorf, D.J., Kliewer, S.A., Repa, J.J. Proc. Natl. Acad. Sci. U.S.A. (2003)
- Regulation of rat organic anion transporters in bile salt-induced cholestatic hepatitis: effect of ursodeoxycholate. Rost, D., Herrmann, T., Sauer, P., Schmidts, H.L., Stieger, B., Meier, P.J., Stremmel, W., Stiehl, A. Hepatology (2003)
- Severe cholestasis induced by cholic acid feeding in knockout mice of sister of P-glycoprotein. Wang, R., Lam, P., Liu, L., Forrest, D., Yousef, I.M., Mignault, D., Phillips, M.J., Ling, V. Hepatology (2003)
- Hepatic overexpression of murine Abcb11 increases hepatobiliary lipid secretion and reduces hepatic steatosis. Figge, A., Lammert, F., Paigen, B., Henkel, A., Matern, S., Korstanje, R., Shneider, B.L., Chen, F., Stoltenberg, E., Spatz, K., Hoda, F., Cohen, D.E., Green, R.M. J. Biol. Chem. (2004)
- Development of an intravenous bile acid tolerance test. Plasma disappearance of cholylglycine in health. Korman, M.G., LaRusso, N.F., Hoffman, N.E., Hofmann, A.F. N. Engl. J. Med. (1975)
- Abnormal hepatic sinusoidal bile acid transport in an Amish kindred is not linked to FIC1 and is improved by ursodiol. Morton, D.H., Salen, G., Batta, A.K., Shefer, S., Tint, G.S., Belchis, D., Shneider, B., Puffenberger, E., Bull, L., Knisely, A.S. Gastroenterology (2000)
- Metabolism of 5-fluorouracil to an N-cholyl-2-fluoro-beta-alanine conjugate: previously unrecognized role for bile acids in drug conjugation. Sweeny, D.J., Barnes, S., Heggie, G.D., Diasio, R.B. Proc. Natl. Acad. Sci. U.S.A. (1987)
- Bile acid metabolism in human hyperthyroidism. Pauletzki, J., Stellaard, F., Paumgartner, G. Hepatology (1989)