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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

ERLIN1  -  ER lipid raft associated 1

Homo sapiens

Synonyms: C10orf69, Endoplasmic reticulum lipid raft-associated protein 1, Erlin-1, KE04, KEO4, ...
 
 
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High impact information on ERLIN1

  • Two of these proteins, KE04p and C8orf2, were found to be highly enriched in the detergent-insoluble, buoyant fraction of sucrose gradients in a cholesterol-dependent manner [1].
  • Identification and characterization of a novel gene KE04 differentially expressed by activated human dendritic cells [2].
  • KE04 mRNA expression was detectable in various human tissues and cell lines by Northern blot and RT-PCR [2].
  • The majority of 3-benzazepines [KS02, KM57, KN50, KE04, KI10, KP80] was ineffective for plasmid curing, however, inhibited the ADCC reaction, but they did not show a real dose-dependent effect [3].
 

Biological context of ERLIN1

References

  1. Erlin-1 and erlin-2 are novel members of the prohibitin family of proteins that define lipid-raft-like domains of the ER. Browman, D.T., Resek, M.E., Zajchowski, L.D., Robbins, S.M. J. Cell. Sci. (2006) [Pubmed]
  2. Identification and characterization of a novel gene KE04 differentially expressed by activated human dendritic cells. Li, N., Huang, X., Zhao, Z., Chen, G., Zhang, W., Cao, X. Biochem. Biophys. Res. Commun. (2000) [Pubmed]
  3. Plasmid elimination and immunomodulation by 3-benzazepines in vitro. Motohashi, N., Kawase, M., Saito, S., Miskolci, C., Berek, L., Molnár, J. Anticancer Res. (1999) [Pubmed]
  4. Cloning and characterization of a novel gene (C8orf2), a human representative of a novel gene family with homology to C. elegans C42.C1.9. Ikegawa, S., Isomura, M., Koshizuka, Y., Nakamura, Y. Cytogenet. Cell Genet. (1999) [Pubmed]
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