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SPHAR  -  S-phase response (cyclin related)

Homo sapiens

Synonyms: Protein SPHAR, S-phase response protein
 
 
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Disease relevance of SPHAR

 

High impact information on SPHAR

  • In agreement with this proposal, normal cells transfected with an antisense SPHAR expression vector have a significantly reduced rate of DNA synthesis during S phase and a prolonged G2 phase, reflecting the need for postreplicative DNA processing before entry into mitosis [1].
 

Analytical, diagnostic and therapeutic context of SPHAR

  • Rabbit antiserum directed against a SPHAR peptide detects a protein of 7.9 kDa in Western blots (immunoblots) of whole-cell extracts from proliferating, but not resting, fibroblasts [1].
  • By using library partition and microinjection of in vitro-transcribed RNA, a cDNA clone, pSPHAR (S-phase response), which is able to correct the permanent repression of semiconservative DNA synthesis rates characteristic of these cells, was isolated [1].

References

  1. Irreversible repression of DNA synthesis in Fanconi anemia cells is alleviated by the product of a novel cyclin-related gene. Digweed, M., Günthert, U., Schneider, R., Seyschab, H., Friedl, R., Sperling, K. Mol. Cell. Biol. (1995) [Pubmed]
  2. Activation of mammalian Chk1 during DNA replication arrest: a role for Chk1 in the intra-S phase checkpoint monitoring replication origin firing. Feijoo, C., Hall-Jackson, C., Wu, R., Jenkins, D., Leitch, J., Gilbert, D.M., Smythe, C. J. Cell Biol. (2001) [Pubmed]
  3. Oxidative stress induces protein phosphatase 2A-dependent dephosphorylation of the pocket proteins pRb, p107, and p130. Cicchillitti, L., Fasanaro, P., Biglioli, P., Capogrossi, M.C., Martelli, F. J. Biol. Chem. (2003) [Pubmed]
 
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