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Gene Review

FRS3  -  fibroblast growth factor receptor substrate 3

Homo sapiens

Synonyms: FGFR substrate 3, FGFR-signaling adaptor SNT2, FRS2-beta, FRS2B, FRS2beta, ...
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High impact information on FRS3

  • In the present report, we show that expression of SNT-2 suppressed EGF-induced cell transformation and proliferation, and expression level of SNT-2 is downregulated in cancer [1].
  • Altogether, our data indicate that the FRS2 and FRS3 adapters may have a role in thyroid carcinogenesis triggered by TRK oncogenes [2].
  • In addition, RNAi-mediated decrease in ULK2 causes increased interaction between FGFR1 and FRS3 [3].
  • In contrast, the mutant SNT-2 which carries deletion of 186-252 amino acids and lacks ERK2 binding does not have these effects [4].
  • Both FRS2 and FRS3 contain 5 coding exons spanning over 7 kb of genomic sequence with similar exon sizes and organization [5].

Biological context of FRS3

  • Non-coding sequences, highly conserved between mouse and human, were identified in the FRS3 introns that may potentially function as regulatory elements [5].

Associations of FRS3 with chemical compounds

  • Luminescent silica nanotubes SNT-2 (loaded with coumarion laser dye 2) and SNT-3 (loaded with anthracene laser dye 3) were prepared by sol-gel cocondensation of functional dyes and TEOS in a cholesterol-based organogel system [6].

Other interactions of FRS3

  • Furthermore, SNT-2 constitutively bound to EGFR through the phosphotyrosine binding (PTB) domain both with and without EGF stimulation [1].

Analytical, diagnostic and therapeutic context of FRS3

  • To assay potential differences in their patterns of expression, RT-PCR analysis was used to assay FRS2 and FRS3 expression in the developing embryo and neural tube (NT) during the time of neurogenesis [5].
  • Comparative genomic sequence analyses show a highly conserved genomic organization between mouse and human in both FRS2 and FRS3 genes [5].


  1. Unique role of SNT-2/FRS2beta/FRS3 docking/adaptor protein for negative regulation in EGF receptor tyrosine kinase signaling pathways. Huang, L., Watanabe, M., Chikamori, M., Kido, Y., Yamamoto, T., Shibuya, M., Gotoh, N., Tsuchida, N. Oncogene (2006) [Pubmed]
  2. The signaling adapters fibroblast growth factor receptor substrate 2 and 3 are activated by the thyroid TRK oncoproteins. Ranzi, V., Meakin, S.O., Miranda, C., Mondellini, P., Pierotti, M.A., Greco, A. Endocrinology (2003) [Pubmed]
  3. UNC-51-like kinase regulation of fibroblast growth factor receptor substrate 2/3. Avery, A.W., Figueroa, C., Vojtek, A.B. Cell. Signal. (2007) [Pubmed]
  4. SNT-2 interacts with ERK2 and negatively regulates ERK2 signaling in response to EGF stimulation. Huang, L., Gotoh, N., Zhang, S., Shibuya, M., Yamamoto, T., Tsuchida, N. Biochem. Biophys. Res. Commun. (2004) [Pubmed]
  5. Genomic organization and comparative sequence analysis of the mouse and human FRS2, FRS3 genes. Zhou, L., McDougall, K., Kubu, C.J., Verdi, J.M., Meakin, S.O. Mol. Biol. Rep. (2003) [Pubmed]
  6. Fabrication of color-tunable luminescent silica nanotubes loaded with functional dyes using a sol-gel cocondensation method. Han, W.S., Kang, Y., Lee, S.J., Lee, H., Do, Y., Lee, Y.A., Jung, J.H. The journal of physical chemistry. B, Condensed matter, materials, surfaces, interfaces & biophysical. (2005) [Pubmed]
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